Custom Peptides
Cayman Chemical BretylIumtosylate 10mg
A class III antiarrhythmic agent; has antiadrenergic activity in isolated tissue preparations; an inhibitor of the Na+/K+-ATPase (IC50 = 4.5 mM); prevents ventricular fibrillation in anesthetized dogs in a model of sudden coronary death at 10 mg/kg; inhibits NCTs, as well as increases action potential delay and the absolute refractory period in isolated mouse vas deferens sympathetic nerve terminals
Cayman Chemical HypaconItIn 10mg
A diterpene alkaloid with diverse biological activities; inhibits nerve stimulation-evoked contractions in isolated mouse phrenic nerve-diaphragm muscle preparations (IC50 = 118 nM); prevents carrageenan-induced paw edema in mice at 0.025 mg/kg; reduces acetic acid-induced writhing in mice (ED50 = 0.1 mg/kg); toxic to mice (LD50 = 1.9 mg/kg, s.c.)
Cayman Chemical nsna wbbauna Notoptl 10mg
A furanocoumarin with diverse biological activities; a JAK2 and JAK3 inhibitor (IC50s = 9.51 and 25.2 µM, respectively); selective for JAK2 and JAK3 over TYK2 and JAK1 (IC50s = >667 and >2,000 µM, respectively); induces apoptosis and mitochondrial membrane depolarization in HL-60 cells at 40 and 60 µM; induces cell cycle arrest at the G0/G1 phase in HL-60 cells at 10, 20, and 40 µM; decreases acetic acid-induced writhing and vascular permeability in mice at 100 mg/kg; increases the duration of pentobarbital-induced sleep in mice at 10 or 30 mg/kg; reduces joint swelling, inhibits decreased talus bone volume, and reduces meniscus and talus osteoclast numbers in a mouse model of collagen-induced arthritis at 20 mg/kg per day
Cayman Chemical ALC-0315 nalogous-1 10mg
An ALC-0315 derivative; has been used in the synthesis of ionizable cationic lipids used in the generation of LNPs
Cayman Chemical AprIcItabIn 10mg
A nucleoside reverse transcriptase inhibitor; reduces HIV-1 infectivity in MT-4 and U937 cells (IC50s = 2.8 and 0.4 µM, respectively), as well as in isolated human CBMCs (IC50 = 0.4 µM)
Cayman Chemical HomobrasInolIde 10mg
A brassinosteroid; field application increases the number of fruits per plant, fruit length, and fruit breadth in tomato plants at 0.12 g/ha
Cayman Chemical R-CetIrIzInhydrochlorIde 10mg
A selective histamine H1 receptor antagonist; the (R)-enantiomer of cetirizine; binds to the H1 receptor with higher affinity than cetirizine (Kis = 3 and 6 nM, respectively) and is highly selective for H1 over M1-M5 receptors; decreases production of RANTES and eotaxin following antigen stimulation in mouse eosinophils in vitro (MEC = 0.05 µM); dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice (0.01-1% solution)
Cayman Chemical D-TetrahydropalmatIn 10mg
A tetrahydroberberine alkaloid; reverses apomorphine-induced inhibition of dopaminergic firing in the SNC in paralyzed rats at 32 mg/kg
Cayman Chemical 1 3DIpalmItoyl2lnoloyl G 10mg
A triacylglycerol; has been found in the palm stearin fraction of palm oil and as a minor component of soybean germ oil
Cayman Chemical Lys05hydrochlorIde 10mg
An inhibitor of autophagy; induces p62 accumulation and increases the ratio of LC3-II to LC3-I in C8161 melanoma cells in a concentration-dependent manner; increases the number of autophagic vesicles per cell in tumors in a C8161 mouse xenograft model and reduces tumor volume and growth in a 1205Lu melanoma mouse xenograft model at 76 mg/kg; reduces tumor growth rate, volume, and weight in an HT-29 colon cancer mouse xenograft model at ≥10 mg/kg but increases bowel thickness and obstruction at 80 mg/kg
Cayman Chemical ACTH4-11humnmousera 10mg
A peptide fragment of ACTH; induces differentiation of melanocytes at 1,000 nM; inhibits ACE activity in homogenized canine lung (IC50 = 24 µM); has been used to determine substrate specificity of recombinant CPBHz
Cayman Chemical CarboxyamIdotrIazole 10mg
An orally bioavailable, non-selective calcium channel blocker; blocks L- and T-type calcium channels in GH3 rat pituitary cancer cells (IC50s = 0.5 and 1.5 μg/ml, respectively); blocks carbachol- and A23187-stimulated calcium influx in CHO cells expressing human recombinant M5 receptors (IC50s = 935 and 359 nM, respectively); inhibits the growth of T. gondii in non-cancerous human fibroblasts and HeLa human cervical cancer cells (IC50 = 0.06 μg/ml for both); inhibits the growth of human FaDu and EVSCC17M squamous cell carcinoma cells (IC50s = 13 and 15 μM, respectively) and of HUVECs (IC50 = 1 μM); inhibits angiogenesis in a chicken chorioallantoic membrane assay in vivo at 20 μM
Cayman Chemical DIhydromethystIcIn 10mg
A kavalactone; a P-gp inhibitor that increases calcein AM uptake by 50% in P388 mouse leukemia cancer cells overexpressing P-gp at 54.6 μM; has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice at 275 mg/kg; decreases the infarct size in a mouse model of MCA-induced ischemia at 10 mg/kg
Cayman Chemical 4-octynyl Itaconate 10mg
An alkyne derivative of 4-octyl itaconate; can be used for click chemistry applications