Custom Peptides
Cayman Chemical 17phenyl trInor ProstglnI 10mg
The 1,15 lactone of 17-phenyl-trinor PGF2α with potential for suitable pharmacologic activity and an improved side-effect profile over current glaucoma therapeutics
Cayman Chemical EpIpregnolon 10mg
A neurosteroid and an active metabolite of pregnenolone; inhibits spontaneous contractions in myometrial strips isolated from at-term pregnant women (IC50 = 156 µM); decreases operant alcohol self-administration in rats at 10 and 20 mg/kg
Cayman Chemical R- Docosahexaenyl-2-Hyd 10mg
A homolog of DHEA, characterized by the addition of an (R)-β-methyl group at the terminal ethanolamine carbon
Cayman Chemical GInsenosIde Rb3 10mg
A steroid glycoside with diverse biological activities; inhibits OGD-induced JNK-mediated activation of NF-κB and apoptosis in H9c2 mouse cardiac myoblasts; reduces myocardial apoptosis and production of ROS in a rat model of myocardial ischemia-reperfusion injury at 20 mg/kg; prevents increases in serum creatinine, BUN, MDA, and decreases in SOD activity and GSH levels, as well as inhibits renal cell apoptosis in a mouse model of cisplatin-induced nephrotoxicity at 10 and 20 mg/kg; decreases the abundance of cancer cachexia-associated gut microbiota and the number of polyps in the ApcMin/+ mouse model of colon cancer; decreases immobility time in the forced swim and tail suspension tests in mice
Cayman Chemical KalIdIn380-389humnpo 10mg
An endogenous kinin peptide agonist of bradykinin B2 and B1 receptors; binds to bradykinin B2 (IC50 = 0.63 nM) and B1 receptors (Ki = 3.23 nM); levels in interstitial muscle are increased in women with work-related trapezius myalgia
Cayman Chemical 3a-AmInocholestn 10mg
An inhibitor of SHP-1 (IC50 = ~2.5 µM); selective for SHP-1 over SHP-2 and PTEN (IC50s = >20 µM); induces hyperactivation of SYK in patient-derived Ph+ ALL cells; reduces leukemia burden and increases survival in a tyrosine kinase inhibitor-resistant patient-derived Ph+ ALL mouse xenograft model at 50 mg/kg; reduces cell viability of OPM2 cells in a concentration-dependent manner and of RPMI8226 cells at ≥12.5 µM; halts the cell cycle at the G0/G1 or G2/M stages in the highly proliferative OPM2 or less proliferative RPMI8226 cell lines, respectively; induces apoptosis via activation of caspase-3, caspase-9, and PARP in OPM2 cells but not in RPMI8226 cells
Cayman Chemical nrIum IndIcum ndrosIn 10mg
A phenol glucoside with diverse biological activities; active against the bacteria S. aureus, S. epidermidis, P. aeruginosa, E. cloacae, K. pneumoniae, and E. coli (MICs = 0.6-1.08 mg/ml) and the fungi C. albicans, C. tropicalis, and C. glabrata (MICs = 1.85, 1.7, and 1.65 mg/ml, respectively); inhibits bronchial obstruction in guinea pig model of asthma induced by ovalbumin or PAF at 10 mg/kg
Cayman Chemical 17phenyl trInor Prostglnd 10mg
17-phenyl trinor PGD2 is a novel, chemically stable analog of PGD2 wherein the lower side chain is modified by the addition of a phenyl group at C-17 in place of the last 3 ω-chain carbon atoms. This modification has not been reported in a D-type prostaglandin. However, in the PGE and PGF series, the analogous modification leads to a stable, somewhat more potent agonist which embodies the same biological activities as the parent prostaglandins.
Cayman Chemical Coclaurn 10mg
A benzylisoquinoline alkaloid; inhibits ACh-induced currents in Xenopus oocytes expressing human α4β2 or α4β4 subunit-containing nAChRs (IC50s = 49 and 18 µM, respectively); induces mortality in D. melanogaster and C. pomonella larvae (LD50s = 78.2 and 35.4 UG/ml, respectively)
Cayman Chemical GSK1702934A 10mg
A TRPC3 and TRPC6 activator; induces TRPC3- and TRPC6-dependent currents in whole-cell patch-clamp assays using HEK293 cells expressing human channels (EC50s = 0.08 and 0.44 µM, respectively); enhances contractility and induces arrhythmias in hearts isolated from TRPC3-overexpressing mice
Cayman Chemical PIxntronmaleate 10mg
A DNA topoisomerase II inhibitor; induces SV40 DNA cleavage in the presence of mouse topoisomerase II; induces DNA single-strand breaks in NCI H187 cells; is cytotoxic to L1210 cells as well as doxorubicin-sensitive and -resistant LoVo cells (IC50 = 0.01, 0.24, and 7.2 UG/ml, respectively); decreases disease severity in a rat model of T. californica AChR immunization-induced myasthenia gravis at 8.12 mg/kg once per week for six weeks
Cayman Chemical GBR 12783hydrochlorIde 10mg
A dopamine uptake inhibitor (IC50 = 13 nM in rat striatal synaptosomes); selective for inhibition of dopamine uptake over norepinephrine or 5-HT uptake (IC50s = 230 and 1,100 nM in rat hypothalamic and striatal synaptosomes, respectively); improves learning and memory in the passive avoidance test in rats at 10 mg/kg, i.p., an effect that can be blocked by scopolamine; increases locomotor activity, reduces pentobarbital-induced sleep duration, and decreases immobility time in the forced swim test, in mice; inhibits haloperidol-induced catalepsy in rats at 10 mg/kg
Cayman Chemical 13 Z-DocosenoIc AcIdodIum 10mg
A 22-carbon monounsaturated fatty acid; increases weight gain and heart triglyceride levels in calcium-deprived weanling rats in the diet at 6.6% w/w
Cayman Chemical C8 GalactosylcRamIDd18 1 10mg
A synthetic bioactive sphingolipid; increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated in the nanoliposomal membrane of nanoliposomal-doxorubicin; induces proliferation and cytokine production by splenocytes in vitro (100-1,000 ng/ml); activates NF-κB production in C6 glioma cells (10 μM)