Custom Peptides
Cayman Chemical Methoxy-X04 10mg
A fluorescent probe for Aβ; used to detect and quantify plaques, tangles, and cerebrovascular amyloid; high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits; used for in vivo imaging in APP/PS1 mice; displays an excitation peak at 750 nm with emission between 460 and 500 nm
Cayman Chemical RIstocetIn Asulfate 10mg
An antibiotic used in the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay, for the diagnosis of von Willebrand disease and other bleeding disorders
Cayman Chemical RWJ 52353hydrochlorIde 10mg
An α2D-AR agonist (Kis = 1.5, 254, 621, and 443 nM for α2D-, α2A-, α2B-, and α1-ARs, respectively); has antinociceptive properties in the mouse and rat abdominal irritation tests (ED50s = 11.6 and 15.1 mg/kg, respectively)
Cayman Chemical INCB 3284dImesylate 10mg
A potent, selective, and orally bioavailable antagonist of MCP-1 binding to CCR2 (IC50 = 3.7 nM); inhibits chemotaxis in vitro (IC50 = 4.7 nM) and displays acceptable oral bioavailability in mice, rats, dogs, monkeys, and chimpanzees
Cayman Chemical MBZPhydrochlorIde 10mg
An analytical reference standard categorized as a piperazine; intended for research and forensic applications
Cayman Chemical 1ArachIdoyl2Oleoyl3PalmI 10mg
A triacylglycerol; has been found in a variety of plant oils, including poppy seed, hazelnut, maize, olive, yellow melon, and date seed oils
Cayman Chemical RHPS4methyl sulfate 10mg
A telomerase inhibitor (IC50 = 0.33 µM); a ligand for the G-quadruplex; induces telomeric DNA damage in BJ fibroblasts expressing human telomerase at 1 µM; inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 13.18 µM), as well as induces cell cycle arrest at the S-G2/M and apoptosis in M14 melanoma cells from 0.5-10 µM; reduces tumor growth in several mouse xenograft models at 10 mg/kg
Cayman Chemical RetatrutIdesodIum salt 10mg
A GCGR, GLP-1R, and GIP receptor agonist; induces cAMP accumulation in HEK293 cells expressing the human GCGR, GLP-1R, or GIP receptor (EC50s = 5.79, 0.775, and 0.0643 nM, respectively); decreases plasma glucose levels in an intraperitoneal glucose tolerance test in mice from 0.1-30 nmol/kg; decreases body weight, calorie intake, fat mass, and lean mass in a mouse model of diet-induced obesity; acute administration delays gastric emptying and chronic administration for 10 days decreases food intake and body weight in mice
Cayman Chemical RobenacoxIb 10mg
An NSAID and COX-2 inhibitor (Ki = 30 nM for the human enzyme); selective for COX-2 over COX-1 (Ki = 800 nM for the ovine enzyme); inhibits IL-1β-induced PGE2 production in human dermal fibroblasts (IC50 = 31 nM); reduces carrageenan-induced paw edema (ID50 = 0.4 mg/kg), has antinociceptive activity in the Randall-Selitto test, and inhibits LPS-induced fever in rats
Cayman Chemical 1PalmItol2Docosahexaenol 10mg
A phospholipid; found in the nucleus, but not the mitochondria, of mouse liver; levels are lower in pre-term infant plasma compared with maternal and fetal plasma
Cayman Chemical 10deACtyl7xylosyl PaclIta 10mg
A microtubule disruptor; induces the disassembly of pig brain and Physarum microtubules in cell-free assays (IC50s = 0.3 and 0.5 µM, respectively); inhibits proliferation of (IC50 = 5 µM), as well as induces cell cycle arrest at the G2/M phase and apoptosis in, PC3 cells