Custom Peptides
Meso Scale Discovery RPLEX HUM PYY active ASYQP
The R-PLEX Hu PYY Active Assay Kit from Meso Scale Discovery is a multiplex immunoassay that measures active PYY levels in human serum plasma and cell culture supernatants The assay uses electrochemiluminescence detection technology and provides high sensitivity broad dynamic range and requires low sample volume The kit includes a 96-well plate coated with capture antibody detection antibody read buffer wash buffer blocker solutions calibrator and controls The active assay format specifically measures the biologically active form of PYY
Cayman Chemical OSILODROSTAT 10MG
An aldosterone synthase inhibitor; selective for human aldosterone synthase over rat aldosterone synthase (IC50 = 160 nM); inhibits increases in plasma aldosterone levels induced by angiotensin II or ACTH in rats (ED50s = 0.6 and 1.1 mg/kg, respectively); reduces mean arterial pressure and prolongs survival in rats expressing human renin and angiotensinogen, a double-transgenic model of angiotensin II-dependent hypertension, in a dose-dependent manner
Cayman Chemical PolIumosIde 10mg
A phenylethanoid glycoside; scavenges DPPH and ABTS radicals (IC50s = 10.9 and 19.9 µM), as well as inhibits the activity of PKCα (IC50 = 24.4 µM), in cell-free assays); reduces LPS-induced production of TNF-α and IL-6 in RAW 264.7 cells from 12.5-100 µM; decreases glutamate-induced cytotoxicity in primary rat cortical neurons at 0.1, 1, or 10 µM
Cayman Chemical ACTH3-24humnmousera 10mg
A potential impurity found in commercial preparations of cosyntropin
Cayman Chemical LItrIntrIfluoroacetAT sal 10mg
A peptide with diverse biological activities; an agonist of the GRPR and the NMB receptor in BALB/c 3T3 fibroblasts expressing the human receptors (EC50s = 0.44 and 0.03 nM, respectively); binds to frog BB4 in CHO-K1 cells (Ki = 1.2 nM); induces contractions of isolated guinea pig gallbladder at 10-100 ng/kg; decreases food intake in rats at 4-128 UG/kg
Cayman Chemical HCKFWWtrIfluoROCTAte salt 10mg
A thiol-containing peptide; has been used as an analyte in the development of zirconium nanoparticles as probes and matrices for mass spectrometry applications
Cayman Chemical BIOnT FluorIn Fragmnt lbr 10mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 19F NMR raw data file • Aqueous buffer 1H NMR raw data file • 19F NMR chemical shifts • Structures and physiochemical properties in an sd file The parameters used in the design of the library are: • Heavy atoms ≤ 21 • clogP ≤ 3 • Hydrogen bond donors ≤ 2 • Hydrogen bond acceptors ≤ 4 • tPSA ≤ 72 • Rotatable bonds ≤ 3
Cayman Chemical PropIophenon 10mg
An analytical reference standard categorized as a precursor in the synthesis of cathinones; intended for research and forensic applications
Cayman Chemical CalcInurIn SubstrATtrIflu 10mg
A synthetic peptide substrate; can be used as a substrate to quantify calcineurin activity
Cayman Chemical HexaDArgInIntrIfluoroace 10mg
A furin inhibitor (Ki = 100 nM); inhibits West Nile virus NS3 protease (Ki = 478 nM); reduces the proliferation, invasion, and migration of SW 1990 and PaTu 8988 pancreatic cancer cells, as well as decreases the levels of N-cadherin and vimentin and increases E-cadherin levels in the same cells at 1 UG/ml; improves survival in a rat model of anthrax toxemia induced by protective antigen and lethal factor
Cayman Chemical RVG PeptIDtrIfluoROCTAte 10mg
A peptide nAChR antagonist (IC50 = 2.5 µM); LNPs conjugated to RVG peptide selectively traffic to the brain over the lungs and liver in rats; LNPs conjugated to RVG peptide and encapsulating DFO reduce iron levels in the striatum and substantia nigra, as well as decrease levels of ROS and MDA and increase levels of SOD in the substantia nigra in a mouse model of MPTP-induced Parkinson's disease; RVG-containing and DFO-encapsulating LNPs increase the latency to fall in the rotarod test in the same model of MPTP-induced Parkinson's disease
Cayman Chemical PyrIdostIgmIn-d3bromIde 10mg
An internal standard for the quantification of pyridostigmine by GC- or LC-MS
Cayman Chemical AdenylosuccInIc ACDamonIu 10mg
A purine nucleotide and an intermediate in the purine nucleotide cycle; converted into AMP and fumarate by ADSL in the cytosol; inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay at 10 µM; induces contractions in isolated guinea pig uterus strips at 100 µM; increases glucose-induced insulin exocytosis in INS-1 832/13 insulinoma cells at 10 µM; decreases muscle damage and pseudohypertrophy in a dystrophin-deficient mdx mouse model of DMD