Custom Peptides
Cayman Chemical NformylNleLeuPheNleTyr 10mg
A chemotactic peptide; binds to the FPR (Kd = 2.2 nM); has been conjugated to various fluorophores to monitor FPR internalization
Cayman Chemical SB-224289hydrochlorIde 10mg
A potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors
Cayman Chemical GavestInlsodIum salt 10mg
An NMDA receptor antagonist; selectively binds to the glycine site of the NMDA receptor over the glutamate binding site of NMDA, AMPA, or GluK receptors (Kis = 0.003, 10, 7.94, and 3.98 µM, respectively); selective for the NMDA receptor over a panel of 70 receptors (IC50s = >10 µM for all); reduces infarct volume in a rat model of MCAO-induced focal ischemia at 3 mg/kg
Cayman Chemical CGS 21680hydrochlorIde 10mg
A potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM); less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 µM, respectively) and is without effect at adenosine A2B (Ki > 10 µM)
Cayman Chemical GnodermnondIol 10mg
A triterpenoid with diverse biological activities; inhibits the proliferation of Meth A and LLC1 cancer cells (IC50s = 3.4 and 12.5 UG/ml, respectively); reduces the viability of RAW 264.7 macrophages at 20 µM; inhibits fMLF- and cytochalasin B-induced superoxide generation in, and elastase release from, isolated human neutrophils (IC50s = 6.36 and 5.01 UG/ml); inhibits complement-dependent hemolysis of isolated sheep red blood cells (IC50 = 41.7 µM)
Cayman Chemical SPAA-52amonIum salt 10mg
An LMW-PTP inhibitor (Ki = 1.2 nM); greater than 8,000-fold selective for LMW-PTP over 24 phosphatases at 10 µM
Cayman Chemical 2 cyclohexylmethylPLMbagI 10mg
A derivative of plumbagin; selectively cytotoxic to PANC-1 cells in nutrient-deprived medium over PANC-1 cells in DMEM (PC50s = 0.11 and 47.2 µM, respectively); induces apoptosis in PANC-1 cells at 1 µM; selectively reduces Akt and mTOR phosphorylation in PANC-1 cells under nutrient-deprived, but not nutrient-rich, conditions; tumor volume and weight in a MiaPaCa-2 mouse xenograft model at 50 and 250 UG/animal five times per week
Cayman Chemical LaHydroxyglutarIc AcIdod 10mg
An α-hydroxy acid; metabolized to α-ketoglutarate by L-2-hydroxyglutarate dehydrogenase; levels are increased in 2-hydroxyglutaric aciduria; competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation
Cayman Chemical 3-DeoxygunosIn 10mg
A ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors, such as G-coupled receptors, in order to study structure-activity relationships; also used to selectively impair transcription
Cayman Chemical R-LIsofylIn 10mg
A potent inhibitor of the generation of phosphatidic acid (IC50 = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock; suppresses the production of the proinflammatory cytokine IFN-γ, inhibits IL-12 signaling, and enhances glucose-stimulated β-cell insulin secretion; reduces the onset of diabetes in a non-obese diabetic mouse model
Cayman Chemical N-ButylfluoresceIn 10mg
Ex/em = 467/512 nm, respectively; has been used in the synthesis of butyl FLIP, a fluorogenic substrate of PI-PLC
Cayman Chemical 2 3DImethylethcathInonhyd 10mg
A disubstituted analog of ethcathinone; intended for forensic and research purposes