Custom Peptides
Cayman Chemical Ro 046790hydroCLOrID hyd 10mg
A 5-HT6 receptor antagonist (Ki = 44.7 nM); selective for 5-HT6 receptors over a panel of 23 additional receptors at 10 µM; inhibits 5-HT-induced cAMP production in HeLa cells expressing human 5-HT6 (pA2 = 6.75); induces stretching and yawning behavior in rats at 10 and 30 mg/kg; reverses scopolamine-induced decreases in novel object discrimination in rats; attenuates cue-induced cocaine-seeking behavior in rats at 3, 10, and 30 mg/kg
Cayman Chemical Valerolactone 10mg
An analytical reference standard categorized as a prodrug form of γ-hydroxyvaleric acid; intended for research and forensic applications
Cayman Chemical BufuralolhydrochlorIde 10mg
A non-selective antagonist of β-ARs that also has partial agonist activity; decreases mean arterial blood pressure and increases abdominal aortic blood flow in anesthetized cats at 0.3 and 1 mg/kg; has been used as a substrate to measure CYP2D6 activity
Cayman Chemical GJ-103sodIum salt 10mg
An inducer of stop codon read-through; restores the kinase activity of ATM in patient-derived A-T lymphoblastoid cell lines containing homozygous TAG, TGA, or TAA nonsense mutations in ATM at 10 and 30 μM
Cayman Chemical GSK1838705A 10mg
An IGF-1R and IR inhibitor (IC50s = 2 and 1.6 nM, respectively); selective for IGF-1R and IR over a panel of 47 kinases (IC50s = >1,600 nM); inhibits ALK (IC50 = 0.5 nM); inhibits ligand-induced phosphorylation of IGF-1R and IR as well as phosphorylation of Akt, IRS-1, and ERK in MCF-7 breast carcinoma cells; inhibits the growth of a panel of cancer cell lines (EC50s = 24-8,378 nM); completely inhibits IGF-1-induced phosphorylation of IGF-IR, Akt, and IRS-1 as well as reduces tumor growth in the COLO 205 and NIH-3T2/LISN mouse xenograft models at ≥1 and ≥10 mg/kg, respectively; induces tumor cell apoptosis and reduces tumor growth in U87MG glioma and PC3R prostate cancer mouse xenograft models
Cayman Chemical SaroglItazar MagnsIum 10mg
A PPARα and PPARγ dual agonist (EC50s = 0.65 and 3,000 pM, respectively); decreases serum triglyceride, free fatty acid, and glucose levels in a db/db mouse model of diabetes at 0.01-3 mg/kg; increases insulin sensitivity in an oral glucose challenge at 1 mg/kg; reverses palmitic acid-induced decreases in the expression of mRNA encoding SOD1, SOD2, GPX, and catalase and increases in the expression of mRNA encoding TNF-α, IL-1β, and IL-6 in HepG2 cells at 10 µM; decreases hepatic inflammation and steatosis in a mouse model of NASH induced by a choline-deficient high-fat diet at 3 mg/kg
Cayman Chemical DIprovocIm-1 10mg
An agonist of TLR1/TLR2; induces TNF-α release in THP-1 cells (EC50 = 110 pM); increases the production of ovalbumin-specific IgG1 in wild-type mice sensitized to ovalbumin at 10 mg/kg; enhances anti-PD-L1 antibody-induced activation of cytotoxic T lymphocytes, reduction of tumor growth, and increases in survival in a B16/F10 murine melanoma model
Cayman Chemical EltoprazInhydrochlorIde 10mg
A partial agonist at 5-HT1A, 5-HT1B, and 5-HT2B receptors (Kis = 40, 52, and 81 nM, respectively); decreases aggressive behavior in resident-intruder tests with rats (ID50 = 0.24 mg/kg)
Cayman Chemical PralsetInIb 10mg
An inhibitor of RET (IC50s = 0.4, 0.3, 0.4, and 0.4 nM for wild-type RET, RETV804L, RETV804M, and RETM918T, respectively); selective for RET over VEGFR2 (IC50 = 35 nM) and a panel of 371 kinases at 300 nM; inhibits a CCDC6-RET fusion protein and autophosphorylation of RET in Ba/F3 cells expressing a KIF5B-RET fusion protein (IC50s = 0.4 and 5 nM, respectively); induces tumor regression in a KIF5B-RET-positive PDX mouse model of NSCLC at 30 mg/kg
Cayman Chemical Skepnon-L 10mg
An ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 µM); has little effect on a range of other kinases, including p38γ and p38δ; blocks the phosphorylation of HSP27, a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM)
Cayman Chemical AlflutInIbmesylate 10mg
An inhibitor of mutant EGFRs; selective for EGFRL858R, EGFRG719X, EGFRL858R, EGFRL861A, and EGFRT790M mutant EGFRs over wild-type EGFR; reduces tumor growth in an EGFRL858R and EGFRT790M-expressing LU1868 NSCLC PDX mouse model at 10 and 30 mg/kg
Cayman Chemical A779trIfluoroacetAT salt 10mg
A Mas receptor antagonist (IC50 = 0.3 nM); prevents the antidiuretic effects of Ang (1-7) in water-loaded rats (0.01 mg/kg); inhibits the Ang (1-7)-induced decrease in mean arterial pressure (MAP) when administered by microinjection into the nucleus of the solitary tract; has sex-dependent effects on urine flow rate and sodium excretion when AT1 and AT2 receptors are blocked
Cayman Chemical MtAhydrochlorIde 10mg
A designer drug that features a carbonyl group adjacent to a phenyl group, similar to cathinones; also marketed as mephtetramine; intended for forensic and research applications
Cayman Chemical Sphynolacton-7 10mg
An agonist of S. hermonthica ShHTL7; binds to ShHTL7 (IC50 = 0.31 µM) over ShHTL2-6, ShHTL9-1, and the strigolactone receptor AtD14 at 10 µM but does inhibit ShHTL8 and ShHTL11 (IC50s = 1.2 and 7.8 µM, respectively); induces fatal S. hermonthica seed germination (MEC = 10 fM); induces suicidal germination of S. hermonthica seeds and decreases the number of plants emerging from the soil, as well as reduces S. hermonthica-induced senescence in maize plants when pre-applied to the soil of co-cultivated maize plants and S. hermonthica seeds at 10 nM