Custom Peptides
Cayman Chemical UtreglutIde 10mg
A G protein-biased peptide agonist of GLP-1R; selectively induces cAMP accumulation in HEK293 cells expressing human GLP-1R over β-arrestin recruitment in CHO-K1 cells expressing human GLP-1R (EC50s = 0.63 and 79 nM, respectively); induces insulin secretion in INS-1 832/3 cells (EC50 = 6.3 nM); reduces food intake and body weight, increases plasma insulin levels, and decreases plasma glucose, HbA1c, glucagon, and triglyceride levels in diabetic db/db mice from 1.5-6 nmol/kg
Cayman Chemical Taurod4ursodeoxycholc ACD 10mg
An internal standard for the quantification of tauroursodeoxycholic acid by GC- or LC-MS
Meso Scale Discovery RPLEX HUM PYY active ASYQP
The R-PLEX Hu PYY Active Assay Kit from Meso Scale Discovery is a multiplex immunoassay that measures active PYY levels in human serum plasma and cell culture supernatants The assay uses electrochemiluminescence detection technology and provides high sensitivity broad dynamic range and requires low sample volume The kit includes a 96-well plate coated with capture antibody detection antibody read buffer wash buffer blocker solutions calibrator and controls The active assay format specifically measures the biologically active form of PYY
Cayman Chemical ParsaclIsIb 10mg
A PI3Kδ inhibitor (IC50 = 1 nM); selective for PI3Kδ over PI3Kα, PI3Kβ, and PI3Kγ (IC50s = >10,000 nM for all), as well as a panel of 192 additional kinases and a panel of 70 ion channels and transporters at 1 µM; inhibits primary human B cell proliferation (IC50 = 0.2 nM) and memory T cell cytokine production (IC50s = 0.2-1.5 nM); inhibits the differentiation of naïve isolated human T cells into Th1, Th2, or Th17 T helper cells; inhibits the proliferation of JeKo-1, Mino, Rec-1, and JVM-2 lymphoma cells (IC50s = 50s = 2-8 nM); reduces intratumoral phosphorylation of Akt and tumor growth in a Pfeiffer mouse xenograft model from 0.1-10 mg/kg; reduces proteinuria, lymphadenopathy, and the severity of skin lesions in an MRL/MpJ-Fas lpr mouse model of spontaneous SLE at 3 mg/kg; reduces salivary levels of TNFSF13B and plasma levels of anti-SSA and anti-SSB autoantibodies in a NOD.ShiLtJ mouse model of Sjögren’s syndrome
Cayman Chemical N-NonyldeoxynojIrImycIn 10mg
An inhibitor of α-glucosidase and α-1,6-glucosidase (IC50s = 0.42 and 8.4 μM, respectively); increases hepatic glycogen levels in fasted mice and gastrocnemius muscle glycogen levels in both fasted and fed mice at 250 mg/kg per day; increases β-glucosidase activity by 1.65-fold in patient-derived fibroblasts homozygous for the N370S Gaucher disease mutation when added to the culture medium at 5 μM, but inhibits β-glucosidase activity at >60 μM; DNJ inhibits viral replication in BHK-21 cells JEV or DEN-2); has protective effects in a mouse model of lethal JEV challenge at 200 mg/kg per day
Cayman Chemical trns2OctenoylLcarnItIn 10mg
A synthetic carnitine; has been used as a standard for the quantification of carnitines in human urine
Cayman Chemical SKF 83566hydrobromIde 10mg
A dopamine D1 receptor antagonist; reduces dexbenzetimide- and scopolamine-induced locomotor stereotypy in rats at 0.005, 0.01, and 0.03 mg/kg; decreases ghrelin-induced increases in novel object exploration and food intake in rats at 100 UG/kg; reduces schedule-induced polydipsia in rats
Cayman Chemical 7 HydroxyethyltheophylIn 10mg
An internal standard for the quantification of 7-(β-hydroxyethyl)theophylline by GC- or LC-MS
Cayman Chemical IFNaIFNARIN1hydrochlorI 10mg
An inhibitor of the IFN-α-IFNAR protein-protein interaction (Kd = 4 µM for binding to IFN-α); inhibits virus-induced increases in the production of IFN-α and IL-12 in BM-pDCs infected with MVA or VSV at 18 µM; reduces increases in IL-12 production induced by stimulation with CpG 2216 or poly(I:C) in the same cells
Cayman Chemical ArjunolIc AcId 10mg
A triterpene; scavenges DPPH radicals in a cell-free assay at 0.8 mM; prevents arsenic-induced decreases in the activity of SOD1, catalase, GST, and glutathione reductase in mouse brain at 20 mg/kg for four days; reduces tumor growth in an Ehrlich murine spontaneous adenocarcinoma model at 100 and 250 mg/kg for 20 days; reduces cisplatin-induced renal fibrosis and increased kidney TNF-α and IL-1β levels in mice at 100 and 250 mg/kg per day for 10 days
Cayman Chemical Q1-ALC-0315IodIde 10mg
A cationic quaternary ammonium lipid derivative of ALC-0315; LNPs containing Q1-ALC-0315 and ALC-0315 as a CLP and encapsulating mRNA encoding a luciferase reporter induce luciferase expression in the lungs and spleen in mice
Cayman Chemical AvIbactamsodIum salt 10mg
A β-lactamase inhibitor (IC50s = 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively); restores antimicrobial activity of ceftazidime, ceftriaxone, imipenem and piperacillin in vitro (MIC90 reduction 4-1024-fold across 190 E. coli and K. pneumoniae clinical isolates)
Cayman Chemical 3-Methylcrotonyl GlycIn 10mg
A metabolite; found in urine of patients with 3-methycrotonyl glycinuria; inhibits CO2 production and mitochondrial complex II-III and creatine kinase activity in rat cerebral cortex preparations in a concentration-dependent manner; inhibits the Na+/K+-ATPase in purified synaptic membranes from rat cerebrum
Cayman Chemical Epmed folum Epmedn C 10mg
A flavonoid glycoside; scavenges DPPH radicals in a cell-free assay (IC50 = 142 µM); increases proliferation of UMR-106 osteoblasts by 30.4 and 41.6% at 0.1 and 10 µM, respectively; inhibits TPA-induced EAr edema in mice (ED50 = 192 nmol/ear)