Custom Peptides
Cayman Chemical Cardol dIen 10mg
A phenol from cashew nut shell liquid; kills 50, 100, 100, and 100% of S. mansoni worms after 24 hours when used at concentrations of 25, 50, 100, or 200 µM, respectively; LC50 = 32.2 µM after 24 and 48 hours against S. mansoni worms; has been used as a starting material for the synthesis of bis-benzoxazines
Cayman Chemical trcetrapb 10mg
A CETP inhibitor (IC50s = 47 and 51 nM for cholesteryl and triglyceride transfer, respectively); selective for CETP over PLTP, LCAT, and hepatic and lipoprotein lipases at 10 µM; inhibits CETP activity and increases HDL cholesterol levels in serum from transgenic mice expressing human CETP and ApoA1 at 30 mg/kg; increases mean arterial blood pressure in Zucker fa/fa diabetic rats at 60 and 200 mg/kg
Cayman Chemical AfuresertIbhydrochlorIde 10mg
A pan-Akt inhibitor (IC50s = 0.08, 2, and 2.6 nM for Akt1, -2, and -3, respectively); selective for Akt over a panel of 13 kinases (IC50s = >100 nM) but does inhibit PKA, PKG1α, and PKG1β (IC50s = 1.3, 0.9, and 4 nM, respectively); inhibits tumor growth in an SKOV3 mouse xenograft model at 10, 30, and 100 mg/kg
Cayman Chemical 3S 5S-AtrvastatInsodIum 10mg
An enantiomer of atorvastatin that has little or no inhibitory activity against HMG-CoA reductase
Cayman Chemical TaurolIthocholIc AcIdodIM 10mg
A taurine-conjugated form of lithocholic acid; increases caspase-3 and -7 activity in NTCP-transfected Hep3B cells at 75 µM; has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis; serum levels of TLCA increase approximately 5-fold in within two hours during an oral lipid tolerance test in humans
Cayman Chemical 11-ProstaglndIn F2a 10mg
The primary PGD2 metabolite; formed from PGD2 via PGFS in the liver or lung; induces contraction of isolated cat iris sphincter (EC50 = 0.045 µM); induces contraction of isolated human bronchial smooth muscle from 0.1-30 µM; induces ERK and CREB phosphorylation, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor at 0.1 and 1 µM
Cayman Chemical GalactInolhydrate 10mg
An α-galactoside of inositol that serves as a galactosyl donor in the transglycosidase-catalyzed biosynthesis of the raffinose family; generated from myo-inositol and uridine diphosphate galactose in a galactosyltransferase-catalyzed reaction
Cayman Chemical BrasInazole 10mg
An inhibitor of brassinosteroid biosynthesis that at 1 µM can induce morphological changes, including dwarfism and altered leaf color and curling, in dark-grown Arabidopsis and light-grown cress
Cayman Chemical 3 3-2-Chlorophenylmethyle 10mg
An ENPP1 inhibitor (Ki = 50 µM); inhibits urease (IC50 = 84.53 µM for the Jack bean enzyme)
Cayman Chemical Lophathrum gracl sovtxn 10mg
A C-glycosylated flavone; scavenges DPPH radicals in a cell-free assay (IC50 = 370 UG/ml); cytotoxic to HepG2, MCF-7, and HCT116 cancer cells at 50 and 100 UG/ml; inhibits LPS-induced production of TNF-α and IL-6 and decreases iNOS and COX-2 levels in RAW 264.7 cells at 50 UG/ml; reduces cytotoxicity induced by Aβ (25-35) in PC12 cells at 200 UG/ml
Cayman Chemical FSlRY-amIde 10mg
A peptide antagonist of PAR2 which blocks activation by trypsin (IC50 = ~50 μM) but not by the synthetic agonist SLIGRL-NH2; does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein; used to study PAR2 action in cells and in animals
Cayman Chemical FadracIclIb 10mg
An inhibitor of Cdk2 and Cdk9 (IC50s = 4.5 and 20.5 nM, respectively); selective for Cdk2 and Cdk9 over Cdk1, -4, and -7 (IC50s = 278, 193, and 232 nM, respectively); inhibits the proliferation of COLO 205 cells (IC50 = 0.31 µM); inhibits proliferation in a panel of five breast cancer cell lines (IC50s = <0.4 µM for all); decreases phosphorylation of the RNA polymerase II C-terminal domain and RB and induces apoptosis in COLO 205 cells; reduces tumor volume in an EoL-1 mouse xenograft model at 40 and 55 mg/kg; inhibits tumor growth in an HL-60 mouse xenograft model at 70 mg/kg
Cayman Chemical trns2OctenoylLcarnItIn 10mg
A synthetic carnitine; has been used as a standard for the quantification of carnitines in human urine
Cayman Chemical 3OnthrnIloyl2deoxygua 600ug
A fluorescent nucleotide derivative; has been used to probe inhibitor and activator binding sites on UMP kinase isolated from B. subtilis; ex/em = 330/450 nm, respectively