Custom Peptides
Cayman Chemical ncrostatIn-34 10mg
A RIPK1 inhibitor (IC50 = 5.5 µM); inhibits TNF-α-induced necroptosis in FADD-deficient Jurkat cells and L-929 cells (IC50s = 6.67 and 1.35 µM, respectively); inhibits AP20187- and Z-VA-DL-D(OMe)-FMK-induced necroptosis in L-929 cells expressing an FKBP and RIPK1 fusion protein at 10 µM
Cayman Chemical Ala17-MCHtrIfluoroacetate 10mg
An MCH-derived peptide and MCH receptor agonist; binds to MCH1 and MCH2 receptors in CHO cells expressing the human receptors (IC50s = 0.15 and 3.5 nM, respectively); induces calcium mobilization in HEK293 cells expressing the human receptors (EC50s = 17 and 54 nM, respectively)
Cayman Chemical ZotarolImus 10mg
A macrocyclic lactone immunosuppressant; binds to FKBP12 (IC50 = 2.57 nM); inhibits proliferation of human PBMCs, rat splenocytes, and human coronary artery smooth muscle cells (IC50s = 7, 1,337, and 0.8 nM, respectively); has immunosuppressive activity in a one-way mixed lymphocyte reaction using human or rat lymphocytes (IC50s = 1.2 and 1,465 nM, respectively); reduces symptom severity in a rat model of EAE (ED50 = 1.17 mg/kg per day); delays cardiac allograft rejection in rats (ED50 = 3.71 mg/kg per day); inhibits neointimal formation and reduces stenosis in pig coronary arteries when applied at 10 UG/mm to stainless steel balloon expandable stents with phosphorylcholine in a model of restenosis
Cayman Chemical FNIII14sodIum salt 10mg
A peptide inhibitor of cell adhesion; inhibits the adhesion of A375-SM cells to fibronectin-coated plates at 200 UG/ml; inhibits the binding of an antibody targeting the active conformation of β1 integrin on K562 cells and induces the differentiation of ST 13 fibroblasts into adipocytes at 100 UG/ml; decreases atherosclerotic plaque formation in Ldlr-/- mice fed a Western diet; reduces metastatic tumor burden in a 4T1 murine mammary model of metastasis in combination with doxorubicin
Cayman Chemical JWH 018 benzImIdazl nalog 10mg
Replaces the indole core of JWH 018 with a benzimidazole core, which may confer higher selectivity for the CB2 receptor; intended for forensic and research applications
Cayman Chemical 20OAcetylngenol3ngelate 10mg
A diterpene ester with anticancer activity; inhibits the growth of K562, HL-60, KT-1, MCF-7/adr, A549, and NIH3T3 cells at 12.5 µM; induces cell cycle arrest at the G2/M phase, apoptosis, and necrosis in K562 cells from 31.25-500 nM
Cayman Chemical AlflutInIbmesylate 10mg
An inhibitor of mutant EGFRs; selective for EGFRL858R, EGFRG719X, EGFRL858R, EGFRL861A, and EGFRT790M mutant EGFRs over wild-type EGFR; reduces tumor growth in an EGFRL858R and EGFRT790M-expressing LU1868 NSCLC PDX mouse model at 10 and 30 mg/kg
Cayman Chemical 1-DeoxysphngnInm18 0 10mg
An atypical sphingolipid; plasma levels of 1-deoxysphinganine are increased in patients with HSAN1 and GSDI; not converted to canonical sphingolipids or fatty acids and accumulates in mitochondria, inducing mitochondrial fragmentation and dysfunction; accumulates in LLC-PK1 cells and in mouse liver and kidney following application or administration, respectively, of fumonison B1; neurotoxic to dorsal root ganglion neurons in vitro at 1 µM; cytotoxic to DU145 cells (IC50 = ~2 µM) but stimulates DNA synthesis in Swiss 3T3 cells at 1 µM
Cayman Chemical IsorhamntIn-3-OD-GlucosId 10mg
A flavonoid glycoside with diverse biological activities; scavenges DPPH and ABTS radicals in cell-free assays (IC50s = 3.16 and 44.93 UG/ml, respectively); inhibits H. contortus egg hatching and larval development (EC50s = 431.5 and 55.61 UG/ml, respectively); induces lethality in C. elegans (EC50 = 342 UG/ml); inhibits rat lens aldose reductase (IC50 = 0.75 UG/ml) and reduces sorbitol accumulation in lenses, red blood cells, and sciatic nerve in a rat model of STZ-induced diabetes
Cayman Chemical DchIroInosItol 1234 5 6 10mg
A stereoisomer of IP6; identified in soil samples from Madagascar, New Zealand, and the Falkland Islands and in freshwater sediment from Danish lakes
Cayman Chemical Psoala coylfola Bakucol 10mg
A natural meroterpene that has retinol-like effects on gene expression and properties of the skin; has antioxidant and antibacterial actions; inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM)
Cayman Chemical MJ33lIthIum salt 10mg
A selective, reversible inhibitor of the acidic, calcium-independent (ai)PLA2 activity of Prdx6, with optimal inhibition achieved at an MJ33 concentration of 3 mol%; blocks the degradation of DPPC in both whole lung and isolated alveolar type II epithelial cells
Cayman Chemical AMPR22trIfluoroACTAte sal 10mg
An antimicrobial peptide; active against S. aureus, MRSA, P. aeruginosa, and carbapenem-resistant P. aeruginosa (MBCs = 2, 2, 2, and 4 UG/ml, respectively); induces bacterial outer membrane permeability and ATP leakage to the extracellular space in S. aureus and P. aeruginosa; increases survival in a mouse model of sepsis induced by S. aureus at 10 mg/kg
Cayman Chemical TIn MSoporphyrIn IXCLOrId 10mg
A potent, competitive inhibitor of HO activity in vitro (Ki = 14 nM); inhibits hepatic, renal, and splenic HO activity in vivo for extended periods of time; blocks bilirubin production in vivo, decreasing HO activity in animal models of hyperbilirubinemia
Cayman Chemical OctreotIdeacetate 10mg
A somatostatin receptor agonist (Kis = 875, 0.57, 26.8, >1,000, and 6.8 nM for SST1-5 receptors, respectively); selectively binds to SST2 over SST3 and SST5 receptors (IC50s = 0.02, 92.9, and 21.8 nM, respectively); inhibits the secretion of growth hormone in vitro in rat pituitary cells three-fold more potently than somatostatin; inhibits the secretion of growth hormone in vivo in rhesus monkey (ID50 = 0.38 UG/kg per hour); inhibits proliferation of VEGF-stimulated human umbilical endothelial cells (HUVECs) with an EC50 value of approximately 1 µM; inhibits growth of LCI-D20 human hepatocellular carcinoma cell tumors in a nude mouse xenograft model when administered at a dose of 50 UG/kg twice daily