Custom Peptides
Cayman Chemical OrnIpresInacetate 10mg
A vasopressin V1A receptor agonist; selectively induces reporter gene expression in HEK293 cells expressing vasopressin V1A and V2 receptors in reporter assays (EC50s = 0.69 and 0.45 nM, respectively, for the human receptors) over cells expressing vasopressin V1B receptors; selective for vasopressin V1A and V2 receptors over the vasopressin V1B receptor and oxytocin receptor (EC50s = 7.5 and 71 nM, respectively); increases arterial blood pressure in rats at 0.1 nmol/kg
Cayman Chemical Sitostenone 10mg
A phytosterol with diverse biological activities; inhibits NO production in RAW 264.7 macrophages (IC50 = 15.9 µM); active against the T. evansi (IC50 = 150 nM); reduces mean blood pressure in normotensive rats at 2 mg/kg; decreases blood glucose levels in dogs at 1.3 and 3 mg/kg
Cayman Chemical TInptIn MetabolIte MC5 10mg
An active metabolite of tianeptine; selectively induces G protein activation in BRET assays using HEK293T cells expressing human MOR over human DOR (EC50s = 0.454 and >100 µM, respectively); decreases immobility in the forced swim test in wild-type mice, but not MOR knockout mice, indicating MOR-dependent antidepressant-like activity at 30 mg/kg
Cayman Chemical ChIkusetsusaponIn IVa 10mg
An oleanane-type triterpenoid with diverse biological activities; inhibits the growth of HL-60 and HCT116 cells (IC50s = 76.23 and 78.11 µM, respectively); reduces LPS-induced increases in iNOS, COX-2, IL-1β, IL-6, and TNF-α levels in PMA-differentiated THP-1 macrophages at 50-200 UG/ml; decreases plasma glucose, triglyceride, and LDL-cholesterol, and increases HDL-cholesterol, levels in a rat model of STZ- and high-fat diet-induced type 2 diabetes at 45-180 mg/kg
Cayman Chemical 4-DemethylpodophylotoxIn 10mg
A lignan; inhibits the assembly of isolated chicken brain tubulin (IC50 = 0.5 µM) and the proliferation of LNCaP and PC3 cells (IC50s = 0.056 and 0.082 µM, respectively)
Cayman Chemical TechtochrysIn 10mg
A flavonoid with diverse biological activities; induces adipogenesis and glucose uptake in 3T3-L1 adipocytes at 12.5, 25, and 50 UG/ml; active against S. aureus, L. monocytogenes, B. subtilis, S. enterica, E. coli, V. cholera, K. pneumonia, S. dysenteriae, and P. aeruginosa (MICs = 24-64 UG/ml); scavenges peroxyl radicals in a cell-free assay at 1 and 10 µM
Cayman Chemical 12-methyl TrIdecnoIc AcId 10mg
A methylated fatty acid; has been found in bovine milk; topical ocular application decreases angiogenesis and corneal opacity in mouse models of alkali- or P. aeruginosa-induced eye injury at 200 µM
Cayman Chemical RS 25344hydrochlorIde 10mg
A PDE4 inhibitor (IC50 = 0.3 nM); selective for PDE4 over PDE1, -2, and -3 (IC50s = >100 µM for all); inhibits concanavalin A-induced IL-5 release and LPS-induced TNF-α release in isolated human PBMCs (EC50s = 0.3 and 5.4 nM, respectively)
Echelon Biosciences Research Labs Gastric Inhibitory Peptide (GIP), human - 0.5 mg, CAS#: 100040-31-1
Gastric Inhibitory Peptide (GIP), human - 0.5mg , Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH Category/Application: Neuropeptides Hormones This item is non returnable
Cayman Chemical Uncaa yncopyla sutn 10mg
An indole with diverse biological activities; selectively inhibits BChE (IC50s = 1.97 and 4.97 µM for the human and horse enzymes, respectively) over AChE, for which it has no activity; an inhibitor of 5-HT3A and 5-HT3AB (IC50s = 65.35 and 28.44 µM, respectively); reduces glutamate-induced increases in cell death in HT22 cells at 50 and 100 µM; induces apoptosis in A549 and H1299 NSCLC cells at 40, 60, and 80 µM; reduces tumor growth and intratumoral levels of phosphorylated GSK3β in an A549 mouse xenograft model at 10 mg/kg; also reduces infarct size and cardiac cell apoptosis and prevents cardiac dysfunction in a rat model of ischemia-reperfusion injury at 20 mg/kg
Cayman Chemical Gastroda elta Parshn B 10mg
A phenolic glycoside with anti-asthmatic activity; decreases specific airway resistance and leukocyte infiltration in BALF in a guinea pig model of allergen-induced asthma stimulated by ovalbumin inhalation at 50 mg/kg
Cayman Chemical ErIodIctyol 7-O-glucosIde 10mg
A flavanone glucoside; scavenges hydroxyl and superoxide anion radicals in cell-free assays (IC50s = 0.28 and 0.3 mM, respectively); activates Nrf2 in a reporter assay; protects against cisplatin-induced cytotoxicity in HRMCs, but not A549 or MDA-MB-231 cells, at 80 µM; attenuates neurological deficits and reduces infarct volume in a rat model of MCAO-induced cerebral ischemia at 30 mg/kg
Cayman Chemical IsolarIcIresInol 10mg
A lignan; scavenges ABTS radicals in a cell-free assay (IC50 = 19.4 µM); inhibits LPS-induced NO production in RAW 264.7 macrophages (IC50 = 84.45 µM); inhibits Aβ42 self-aggregation in a cell-free assay at 20 µM
Cayman Chemical RhodIola rosea RosarIn 10mg
A glycoside with anti-inflammatory and immune regulatory activities; prevents LPS-induced increases in iNOS, TNF-α, IL-1β, and IL-6 levels in BV-2 microglia at 10 and 50 UG/ml; inhibits concanavalin A- or anti-CD3 and anti-CD28 antibody-induced growth of Jurkat T cells (IC50s = 60 and 68 µM, respectively); increases TRAIL levels in isolated mouse splenic T cells
Cayman Chemical U-99194maleate 10mg
A dopamine D3 receptor antagonist (Ki = 160 nM for the human receptor); selective for dopamine D3 receptors over the α1-AR (Ki = 8,913 nM for the rat receptor), M1 mAChR, 5-HT1A, and dopamine D4 receptor (Kis = 2,090, 4,230, and >10,000 nM for the human receptors); reverses (+)-7-OH-DPAT- or PD 128907-induced hypothermia in rats (ID50s = 19.1 and 12.9 mg/kg, respectively); increases non-social exploration, social investigation, and the latency to attack in a mouse model of isolation-induced aggressiveness at 40 mg/kg