Custom Peptides
Cayman Chemical RhodIola rosea RosavIn 10mg
A diglycoside with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 5.86 UG/ml); inhibits the proliferation of NCI H69, NCI H526, and NCI H446 SCLC cells at 5-100 µM; inhibits concanavalin A- or anti-CD3 and anti-CD28 antibody-induced growth of Jurkat T cells (IC50s = 80 and 74 µM, respectively) and reduces TRAIL levels in isolated mouse splenic T cells at 0.5, 5, and 50 µM; reduces ferroptosis-related mitochondrial changes and increased levels of 4-HNE and MDA in type II alveolar epithelial cells, as well as reduces lung tissue iron levels, in a rat model of intratracheal PM2.5-induced lung injury at 100 µM
Cayman Chemical ProstaglndIn I2sodIM salt 10mg
PGI2 is an unstable COX metabolite detected first in vascular endothelial cells.{502,443,933} It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 value of 5 nM.{4375} PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto PGF1α in neutral or acidic solutions. The half-life is short both in vivo and in vitro, ranging from 30 seconds to a few minutes. PGI2 is administered by continuous infusion in humans for the treatment of idiopathic pulmonary hypertension.{5466}
Cayman Chemical SureLIghtAlophycocynInA 10mg
Immunogen Synthetic peptide from the C-terminal region of human nNOS Host Rabbit Cross Reactivity (−) eNOS and iNOS Species Reactivity ( ) Human and rat Applications ICC IHC and WB
Cayman Chemical 6a-ProstaglndIn I1 10mg
6α-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cAMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response.{11172} 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).{11183}
Cayman Chemical CarnosIc AcId 10mg
An antioxidant derived from rosemary and common sage that inhibits lipid peroxidation and scavenges peroxyl radicals; cytotoxic towards various human cancer cell lines, reducing cell viability to 13-30% at 6.25 UG/ml
Cayman Chemical Bromoenol lacton 10mg
BEL is a selective, irreversible, mechanism-based inhibitor of iPLA2 with a Ki value of 180 nM.{1631} It inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM.{1291,1770}
Cayman Chemical Methylcarbamyl PAF C-16 10mg
Methylcarbamoyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.{613,4944} It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in PRP.{613} In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamoyl PAF C-16 cause the induction of c-myc and c-fos and the activation of MAPK.{4944} Methylcarbamoyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.{4944}
Cayman Chemical AlocryptopIn 10mg
An isoquinoline alkaloid; active against S. aureus, P. aeruginosa, and E. coli (MICs = 250, 125, and 125 UG/ml, respectively), P. falciparum and E. histolytica (IC50s = 5.08 and 135 µM, respectively), and a panel of seven phytopathogenic fungi (IC50s = 15.2-42.4 UG/ml)
Cayman Chemical SIsunatovIr 10mg
An RSV fusion inhibitor (IC50 = 0.9 nM); reduces RSV A2 replication in a plaque reduction assay in vitro (EC50 = 1.3 nM); decreases lung viral titers in a mouse model of RSV infection at 1, 10, or 50 mg/kg
Cayman Chemical MIrodenafIlhydrochlorIde 10mg
A PDE5 inhibitor; increases penile ICP in rat models of STZ-induced diabetes and cavernosal nerve injury at 1 and 10 mg/kg, respectively; decreases bladder wall submucosal fibrosis and degeneration in a rat model of chronic bladder ischemia at 4 mg/kg per day; decreases bladder overactivity in a female rat model of partial bladder outlet obstruction
Cayman Chemical 1 2DIpalmItoyld62snglycer 10mg
An internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC
Cayman Chemical PIperoxnhydrochlorIde 10mg
An α2-AR antagonist (Kis = 5.4, 2, and 1.3 nM for α2A-, α2B-, and α2C-ARs, respectively); reverses decreases in systolic blood pressure induced by clonidine in spontaneously hypertensive rats at 10 mg/kg
Cayman Chemical SKQ1bromIde 10mg
A mitochondrial antioxidant; decreases transmembrane potential and production of ROS; prevents neuronal loss and synaptic damage in rat AD model; slows development of ocular pathologies; prevents acute phenoptosis following rhabdomyolysis, stroke, and myocardial infarction