Custom Peptides
Cayman Chemical AsIatIcosIde B 10mg
A triterpenoid glycoside; cytotoxic to HepG2 and MCF-7 cancer cells (IC50s = 9.74 and 8.32 µM, respectively)
Cayman Chemical Tegatrabetn 10mg
An inhibitor of Wnt/β-catenin signaling; reduces Wnt3a-induced transcriptional activity in a reporter activity assay using STF3a cells, which exhibit constituitive Wnt activation, at 1 µM; inhibits proliferation of, and DNA transcription in, HT-29 cells (IC50s = 9 and 63 nM, respectively) and reduces survival in six other cancer cell lines (IC50s = 14-80 nM); induces cell cycle arrest at the G1 phase in HCT-15 cells at 625 nM; reduces tumor volume and inhibits lung metastasis in a Saos-2 osteosarcoma xenograft mouse model at 50 mg/kg per day
Cayman Chemical BleomycInsulfate 10mg
A glycopeptide antitumor antibiotic that produces single and double-strand DNA breaks in tumor cells to interrupt their cell cycle; has been used for the treatment of Hodgkin’s lymphoma in combination with doxorubicin, squamous cell carcinomas, testicular cancer, as well as in animal models of pulmonary fibrosis
Cayman Chemical SynthetIc PInosylvIn 10mg
A stilbene with diverse biological activities; activates SIRT1 and induces glucose uptake in isolated rat L6 skeletal muscle myotubes; reduces radial growth in a panel of 28 plant pathogenic fungi at 100 μg/ml; reduces expression of MMP-2, MMP-9, and membrane type 1-MMP in and inhibits migration of HT-1080 cells; reduces the number of tumor nodules and lung tumor weight in a CT26 mouse xenograft model of metastatic colon cancer at 10 mg/kg; decreases hind paw volume and MPO activity in a rat model of adjuvant-induced arthritis; exhibits plant antifeedant activity against L. americanus
Cayman Chemical LInaclotIde 10mg
A peptide agonist of the guanylate cyclase C receptor (Ki = 16.4 nM in a radioligand binding assay using mouse intestinal mucosa); stimulates fluid secretion and cGMP concentration in jejunal loops isolated from wild-type mice but not guanylate cyclase C receptor-null mice; increases intestinal transit rate in wild-type mice when administered at a dose of 100 μg/kg; reduces the number of phosphorylated ERK-positive dorsal horn neurons in the thoracolumbar spinal cord, a marker of nociceptive signaling, following noxious colorectal distension and mechanical hypersensitivity in a mouse model of TNBS-induced colitis
Cayman Chemical N6-CyclopentyladenosIn 10mg
A selective agonist at A1R (Kis = 2.3, 790, and 43 nM for A1R, A2R, and A3R receptors, respectively)
Cayman Chemical 2C-B-FLYhydrochlorIde 10mg
A dihydrodifuran analog of the Schedule I hallucinogen 2C-B, which acts as a partial agonist at the 5-HT2A serotonin receptor; intended for forensic and research purposes
Cayman Chemical FORSYTHOSIDE B 10MG
A phenylpropanoid glycoside with diverse biological activities; scavenges PTIO, ABTS, O2-, and DPPH radicals in cell-free assays (IC50s = 125.5, 14, 262.6, and 8.7 μM, respectively); reduces hydrogen peroxide-induced cytotoxicity in bmMSCs from 10-100 μg/ml; inhibits 2-aminoethoxydiphenyl borate-induced activation of TRPV3 (IC50 = 6.7 μM in HEK293 cells expressing the human receptor); reduces carvacrol-induced scratching behavior in mice; reduces serum levels of TNF-α, IL-6, IL-10, endotoxin, and TREM-1 and increases survival in a rat model of cecal ligation and puncture-induced sepsis at 40 mg/kg; reduces infarct size and brain edema in a rat model of cerebral ischemia and reperfusion injury induced by middle cerebral artery occlusion
Cayman Chemical N8AcetylspermIdInhydrochl 10mg
An endogenous polyamine; urinary levels are increased in patients with chronic pancreatitis; blood levels are increased in patients with ischemic cardiomyopathy, as well as in patients with Parkinson’s disease
Cayman Chemical HIstatIn 3trIfluoroacetAT 10mg
An antimicrobial peptide; active against C. albicans (LC50 = 9.2 µM); induces actin polymerization in a cell-free assay at 12 µM
Cayman Chemical TatCBD3trIfluoroACTAte sa 10mg
An inhibitor of the Cav2.2-CRMP2 protein-protein interaction; inhibits the protein-protein interaction between CRMP2 and the NMDA receptor NR2B subunit; inhibits the Cav2.2-CRMP2 interaction by 43% in a cell-free assay and the NMDA receptor NR2B subunit-CRMP2 interaction in an immunoprecipitation assay at 10 µM; reduces voltage-induced calcium currents by approximately 60% in primary rat DRG neurons and glutamate-induced increases in cytosolic calcium levels in primary rat hippocampal neurons; decreases infarct volume in a rat model of MCAO-induced cerebral ischemia at 20 mg/kg; intrathecal administration prevents carrageenan-induced thermal hypersensitivity in rats
Cayman Chemical MavorIxafor 10mg
A CXCR4 antagonist (IC50 = 13 nM in a radioligand binding assay); selective for CXCR4 over CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2 (IC50s = >10 µM for all); reduces CXCL12-induced chemotaxis of CCRF-CEM T cells (IC50 = 19 nM); inhibits fusion of CHO-K1 cells expressing gp120 to P4 MAGI cells IC50 = 1.5 nM; decreases HIV-1 NL4.3 viral replication in MT-4 cells and isolated human PBMCs (IC50s = 2 and 9 nM, respectively)
Cayman Chemical PunIcalagIn 10mg
An ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects; prevents accumulation of cardiac triglyceride and cholesterol via AMPK-mediated modulation of mitochondria and phase II enzymes
Cayman Chemical RhyncophylIn 10mg
An alkaloid with diverse biological activities; inhibits arachidonic acid-, collagen-, or ADP-induced aggregation of isolated rabbit platelets (IC50s = 0.72, 0.74, and 0.67 mmol/L); decreases the number of sleep-wake cycles and increases total sleep time and REM sleep in rats at 0.25 mg/kg; reduces infarct volume and reverses sensory-motor and spatial memory defects in a mouse model of MCAO-induced stroke at 40 mg/kg; reduces hippocampal production of ROS and MDA levels and decreases escape latency in the Morris water maze test in a mouse model of Aβ42-induced Alzheimer’s disease