Custom Peptides
Cayman Chemical CInamoylglycIn 10mg
A metabolite of trans-cinnamic acid; urinary levels are decreased in a mouse model of piperacillin- and tazobactam-induced gut microbiota colonization resistance; serum levels are increased in patients with CKD
Cayman Chemical TelratolImod 10mg
A TLR7 and TLR8 agonist; increases the HA-induced secretion of IFN-γ in mouse splenocytes; enhances neutralizing antibody responses to a HIV-1 pseudovirus in rhesus macaques for at least one year; reduces tumor growth and increases metastasis-free survival in E0771 and 4T1.2 murine mammary carcinoma models at 0.8 mg/ml, intratumorally; increases intratumoral production of cytokines in a 4T1.2 murine model when administered intratumorally
Cayman Chemical 3-AcetylaconItIn 10mg
A diterpene alkaloid with diverse biological activities; cytotoxic to P388 leukemia cells (IC50 = 18.6 µM); inhibits brevetoxin binding to (IC50 = 1.3 µM), and increases free sodium and calcium concentrations in, rat brain synaptosomes; reduces paw licking, flicking, and shaking in a mouse model of formalin-induced inflammatory pain at 100 UG/kg, i.v.
Cayman Chemical Phylnthus urnara Grn 10mg
A tannin with diverse biological activities; scavenges DPPH (IC50s = 0.92 and 1.27 μM at pH 4.5 and 7.9, respectively), superoxide (IC50 = 2.65 μM), and hydroxyl radicals (IC50 = 1.44 μM) in cell-free assays; inhibits HSV-1 and HSV-2 replication in plaque reduction assays (IC50s = 35 and 18.4 μM, respectively); inhibits ACE (IC50 = 13.22 μM); reduces both systolic and diastolic blood pressure in spontaneously hypertensive rats at 5 mg/kg; induces apoptosis and halts the cell cycle at the S phase in A549 lung cancer cells at 5, 10, and 20 μM; reduces tumor growth in an A549 mouse xenograft model at 10 and 20 mg/kg
Cayman Chemical AS-2444697hydrochlorIde 10mg
An IRAK4 inhibitor (IC50 = 21 nM); greater than 30-fold selective for IRAK4 over a panel of 146 kinases, but is less than 10-fold selective over PDGFRα, PDGFRβ, TrkA, TrkC, CLK1, Itk, and FLT3; inhibits IL-1β-induced IL-6 production and LPS-induced TNF-α production in cellular assays (IC50s = 250 and 47 nM, respectively); efficacious in rat models of adjuvant- and collagen-induced arthritis (ED50s = 2.7 and 1.6 mg/kg, respectively); reduces urinary protein excretion, the development of interstitial fibrosis and glomerulosclerosis, and renal mRNA expression of genes encoding IL-1β, IL-6, TNF-α, and CCL2 in the 5/6 nephrectomized rat model of chronic kidney disease from 0.3-3 mg/kg
Cayman Chemical Osntnthydrate 10mg
An NK3 receptor antagonist (Ki = 0.21 nM in CHO cells expressing the human receptor); selective for NK3 over NK1 and NK2 receptors (Kis = >100 and 0.02 µM, respectively); inhibits neurokinin B-induced contractions and acetylcholine release in isolated guinea pig ileal strips; inhibits ovalbumin-induced increases in BALF neutrophil, eosinophil, and lymphocyte infiltration in an ovalbumin-sensitized mouse model of allergic asthma; has anxiolytic-like and antidepressant-like activities in gerbils at 5 and 10 mg/kg
Cayman Chemical UNC2170maleate 10mg
A micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains on a 53BP1 homodimer; functions as a 53BP1 antagonist in cellular lysates
Cayman Chemical HexahydrocurcumIn 10mg
A natural product and an active metabolite of curcumin; has anti-inflammatory, antioxidant, and anticancer properties; reduces PMA-induced PGE2 production by 37% in human colonic epithelial cells (20 µM); inhibits LPS-induced overproduction of nitric oxide in RAW 264.7 macrophage cells (3.125-25 µM); inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation (50 µM); prevents formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer
Cayman Chemical RhodIola rosea RosarIn 10mg
A glycoside with anti-inflammatory and immune regulatory activities; prevents LPS-induced increases in iNOS, TNF-α, IL-1β, and IL-6 levels in BV-2 microglia at 10 and 50 UG/ml; inhibits concanavalin A- or anti-CD3 and anti-CD28 antibody-induced growth of Jurkat T cells (IC50s = 60 and 68 µM, respectively); increases TRAIL levels in isolated mouse splenic T cells
Cayman Chemical CnaglIflozIn 10mg
An inhibitor of SGLT2 (IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM); lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals
Cayman Chemical UmbelIprenIn 10mg
A prenylated coumarin with diverse biological activities; inhibits 5-LO in a cell-free assay (IC50 = 72.5 nM); active against L. major promastigotes (IC50 = 13.3 µM); induces cell cycle arrest at the G1 phase in, as well as inhibits the growth of (IC50 = 12.5 µM), M4Beu metastatic pigmented melanoma cells; reduces tumor volume in a mouse Lewis lung carcinoma model; reduces tumor growth and the number of metastases in a 4T1 mouse allograft model; reduces carrageenan-induced paw edema in mice at 0.01 mmol/kg
Cayman Chemical HIleProProOHtrIfluoroac 10mg
A peptide ACE inhibitor (IC50 = 5 µM); inhibits acetylcholine-induced NO production in HUVECs at 1 µM; induces vasorelaxation in precontracted isolated rat aortic rings; decreases systolic blood pressure in spontaneously hypertensive rats at 0.3 mg/kg; dietary administration reduces plasma levels of total cholesterol, HDL-cholesterol, and triglycerides, mRNA expression of IL-6 and IL-1β, and aortic arch intimal thickening and atherosclerotic plaque formation in ApoE-/- mice
Cayman Chemical TetrahydroepIberberIn 10mg
An alkaloid with diverse biological activities; active against the fungus C. albicans (MIC = 8 UG/ml), as well as the bacteria E. coli, P. aeruginosa, P. mirabilis, K. pneumoniae, A. baumannii, S. aureus, and B. subtilis (MICs = 32-64 UG/ml, respectively); inhibits the cytopathogenic effect of PI-3 virus in Vero cells at 16 UG/ml; decreases the viability of HaCaT keratinocytes (IC50 = 150 µM)
Cayman Chemical ngIotensIn AtrIfluoroACTA 10mg
An AT1 and AT2 receptor agonist and active metabolite of angiotensin II; binds to AT1 and AT2 receptors in HEK293 cells expressing the rat receptors (IC50s = 0.29 and 0.12 nM, respectively, in radioligand binding assays); induces calcium mobilization in VSMCs (EC50 = 100 nM); increases the perfusion pressure in isolated perfused rat kidney (EC50 = 443 nM), an effect that can be reversed by EXP-3174; the plasma Ang A/Ang II ratio is increased in patients with end-stage renal failure; serum levels are decreased in patients with pulmonary arterial hypertension