Custom Peptides
Cayman Chemical 3-IsomngostIn 10mg
A xanthone with diverse biological activities; an inhibitor of MTH1 (IC50 = 52 nM); inhibits aldose reductase (IC50 = 3.48 µM), AChE (IC50 = 2.36 UG/ml), and BChE (IC50 = 5.32 UG/ml); inhibits the growth of P. falciparum strains D6 and W2 in isolated and infected red blood cells (IC50s = 3.23 and 2.52 UG/ml, respectively); inhibits cyclin D2/Cdk4 and cyclin E1/Cdk2 (EC50s = 15.6 and 34.92 µM, respectively) and reduces viability of HCC1937 and HCT116 cells (IC50s = 59.9 and 47.4 µM, respectively)
Cayman Chemical LEE011succInate 10mg
An inhibitor of Cdk4/6 (IC50s = 0.53 and 2.3 nM, respectively); selective for Cdk4/6 over Cdk1, Cdk2, Cdk5, Cdk7, and Cdk9 (IC50s = >1,400, >2,500, >2,000, >2,000, and 190 nM, respectively); reduces MCF-7 and T47D cell proliferation (IC50s = 200 and 260 nM, respectively); induces cell death in C666-1 and NPC/HK1 cells (IC50s = 12.25 and 5.07 µM, respectively) and cell cycle arrest in the G0/G1 phase in the same cells at 10 µM; reduces tumor growth in combination with alpelisib in two PDX mouse models of nasopharyngeal carcinoma at 200 mg/kg every two weeks
Cayman Chemical Enoctabn 10mg
A prodrug form of cytarabine; resistant to deamination by cytidine deaminase; reduces the virus yield in the supernatant of CMV-infected Vero cells (EC90 = 0.5 UG/ml); inhibits viral DNA synthesis at 5 UG/ml; increases survival in an L1210 murine skin lymphocytic leukemia model
Cayman Chemical ACTH7-38humntrIfluor 10mg
A peptide fragment of ACTH and an antagonist of MC2R; inhibits ACTH-induced corticosterone production in isolated rat adrenal cells at 0.455 or 4.55 µM; inhibits ACE1 (IC50 = 750 nM for the dog enzyme); inhibits basal cAMP secretion by isolated rat inner adrenocortical cells at 1 µM; induces hypotension in normotensive dogs (ED50 = 0.109 nmol/kg)
Cayman Chemical BIOnT FluorIn Fragmnt lbr 10mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 19F NMR raw data file • Aqueous buffer 1H NMR raw data file • 19F NMR chemical shifts • Structures and physiochemical properties in an sd file The parameters used in the design of the library are: • Heavy atoms ≤ 21 • clogP ≤ 3 • Hydrogen bond donors ≤ 2 • Hydrogen bond acceptors ≤ 4 • tPSA ≤ 72 • Rotatable bonds ≤ 3
Cayman Chemical BIOnT PremIM Fragmnt lbra 10mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 3 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3
Cayman Chemical CostunolIde 10mg
A natural sesquiterpene lactone that reduces growth (EC50 = 3-35 μM) and induces apoptosis in assorted cancer cell lines; inhibits the activation of Akt (15 μM) in endometriotic epithelial cells and STAT3 activation in THP-1 cells (EC50 = 10 μM); inhibits telomerase activity in NALM-6 cells
Cayman Chemical CucurbItacIn B 10mg
A plant-derived steroidal triterpene that induces cell cycle arrest or apoptosis in a range of cancer cell lines; inhibits the growth of several breast cancer cell lines (IC50s = 18-50 nM); suppresses the growth of tumors developed from MDA-MB-231 and 4T-1 breast cancer cells in mice
Cayman Chemical L-ErgothIonIn 10mg
A naturally-occurring amino acid which is a stable antioxidant; scavenges free radicals and oxidants, controls NF-κB activation, and inhibits inflammatory gene expression; blocks oxidative DNA damage and cell death
Cayman Chemical RubIadIn-1 methyl ether 10mg
An anthraquinone with diverse biological activities; generates superoxide radicals in isolated human neutrophils and monocytes at 20 UG/ml, an effect that can be enhanced by UV radiation; inhibits M-CSF- and RANKL-induced differentiation of osteoclasts at 0.1, 1, and 10 µM; inhibits C. tropicalis biofilm formation (MIC = 31.3 UG/ml for a clinical isolate); reduces LPS-induced increases in BALF levels of TNF-α, IL-6, and IFN-γ in a mouse model of acute lung injury at 30 mg/kg
Cayman Chemical nlumbo nucIfera Lotusn 10mg
An alkaloid with diverse biological activities; increases cAMP levels in rat myocardium at 0.1-3 µM and cGMP levels in rabbit corpus cavernosum in a concentration-dependent manner; prevents doxorubicin-induced lipid peroxidation in H9c2 embryonic rat cardiomyocytes; increases LVP, LVEDP, and SAP in anesthetized rats at 5 mg/kg
Cayman Chemical GSK2200150A 10mg
An antimycobacterial agent; active against M. tuberculosis and M. bovis (MICs = 0.38 and 1.6 µM, respectively)
Cayman Chemical -Glu-AlatrIfluoroACTAte250mg
A dipeptide; has been found in P. roqueforti; has been found in ripened Gouda, goat, and Milner cheeses; a positive allosteric modulator of CaSR (EC50 = 4.8 µM in CaSR-expressing HEK293 cells); induces glutathionuria in mice at 4 mmol/kg; plasma levels are increased in malnourished neonatal mice; increased serum levels are positively associated with an increased risk of chronic kidney disease
Cayman Chemical 5methoxy TryptamInhydroch 10mg
An analytical reference standard categorized as a tryptamine; intended for research and forensic applications