Custom Peptides
Cayman Chemical SuprafenacIn 10mg
An inhibitor of tubulin polymerization (IC50 = 0.38 μM) with anticancer activit; inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM); increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells at 10 μM; reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model at 20 mg/kg
Cayman Chemical Boldenon CypIonate 10mg
An ester of boldenone, an anabolic androgenic steroid; intended for forensic and research purposes only
Cayman Chemical EmbelIa rIbes EmbelIn 10mg
A benzoquinone with diverse biological activities; inhibits viral replication of the influenza A subtype H1N1 and the influenza B subtype Victoria-like in MDCK cells (IC50s = 0.3 and 0.2 µM, respectively); an inhibitor of XIAP (IC50 = 4.1 µM in a fluorescence polarization assay; induces apoptosis and increases caspase-9 levels in PC3 cells at 20-50 µM; completely inhibits TNF-α-induced NF-κB and IKK activation and inhibits TNF-α-induced IκBα phosphorylation in KBM5 cells at 50 µM; inhibits TNF-α-induced IκBα phosphorylation at 50 µM; active against the Gram-positive bacteria B. subtilis, S. aureus, and M. luteus (MICs = 20, 20, and 25 UG/ml, respectively) and the Gram-negative bacteria P. aeruginosa, K. pneumoniae, and E. coli (MICs = 25, 25, and 45 UG/ml, respectively)
Cayman Chemical PCEEAhydrochlorIde 10mg
A synthetic drug which is structurally related to the psychoactive compounds PCE, ketamine, and PCP; recently been identified as a likely drug of abuse
Cayman Chemical DLGlycRaldehyde3phosphate 10mg
An intermediate in several metabolic pathways, including glycolysis and gluconeogenesis
Cayman Chemical 7 Z 11 Z-NonacosadIen 10mg
A cuticular pheromone in female fruit flies that stimulates male courtship behavior; biosynthesis appears to be mediated by an elongase with female-biased expression
Cayman Chemical 5 Z 8 Z 11 ZEIcosatrIenoI 10mg
A prolyl endopeptidase inhibitor (Kis 0.35 and 0.5 nM for the mouse and human enzymes respectively) inhibits the formation of angiotensin (1-7) from angiotensin II in kidney sections isolated from wild-type and Ace2-/- mice at 4 and 40 UM reduces hippocampal neuronal cell death in a rat model of global ischemia at 10 and 50 mg/kg
Cayman Chemical PapaverInhydrochlorIde 10mg
An analytical reference standard categorized as a muscle relaxant; has been found as an impurity in seized heroin; intended for research and forensic applications
Cayman Chemical VnP16trIfluoroACTAte salt 10mg
A synthetic peptide fragment of vitronectin; induces attachment and cell spreading of isolated human osteogenic cells when applied to cell plates at 9.1 UG/cm2; induces osteogenesis of human skin-derived mesenchymal precursors and MC3T3-E1 mouse calvarial osteoblast precursors; decreases IL-1α-induced bone loss and decreases the number of calvarial osteoclasts in mice; increases bone mineral density and decreases trabecular bone loss in a mouse model of ovariectomy-induced bone loss
Cayman Chemical Glucogallin 10mg
A plant metabolite and an aldose reductase 2 inhibitor (IC50 = 17 µM); inhibits glucose-induced sorbitol accumulation in lenses isolated from a transgenic mouse model overexpressing AKR1B1; reduces methylglyoxal-induced increases in COX-2, IL-6, IL-8, CCL2, and RAGE levels in ARPE-19 retinal epithelial cells
Cayman Chemical DoxorubIcInon 10mg
A metabolite of doxorubicin; inhibits mitochondrial succinoxidase from bovine heart; reduces the mitochondrial inner membrane potential in rat heart and liver mitochondria; increases pentose phosphate pathway flux by 45% and reduces activity of GPx and SOD by 17 and 60%, respectively, in human erythrocytes at 40 μM; induces cytotoxicity in patient-derived ovarian cancer colonies
Cayman Chemical 10deACtyl7xylosyl PaclIta 10mg
A microtubule disruptor; induces the disassembly of pig brain and Physarum microtubules in cell-free assays (IC50s = 0.3 and 0.5 µM, respectively); inhibits proliferation of (IC50 = 5 µM), as well as induces cell cycle arrest at the G2/M phase and apoptosis in, PC3 cells
Cayman Chemical TrIcIrIbIn Phosphate 10mg
An Akt activation inhibitor and active metabolite of triciribine; binds to the PH domain of Akt and prevents its recruitment to the plasma membrane in MDA-MB-468 cells; reduces the proliferation of A1847 and A2780 cells (IC50s = 1.6 and 18 µM, respectively); inhibits HIV-1 reverse transcriptase activity in CEM-SS cells (IC50 = 0.04 µM), as well as HSV-1 replication in BS-C-1 cells and human CMV plaque formation in HFF-1 IRR cells (IC50s = 20 and 0.8 µM, respectively)
Cayman Chemical Nmethyl Perfluoroctnsulfo 10mg
A perfluoroalkyl substance; has been found in landfill leachate