Custom Peptides
Cayman Chemical N 2PocethylbetulIn amIde 10mg
An alkyne derivative of betulin; can be used for click chemistry applications
Cayman Chemical dgwota cysnta Tlosd 10mg
A flavonoid glycoside with diverse biological activities; inhibits CAVII (Ki = 4.6 nM); scavenges DPPH and superoxide radicals (IC50s = 12.8 and 42 µM, respectively); cytotoxic to Jurkat, HepG2, and COLO 205 cells (IC50s = 11.6, 14.3, and 55.4 µM, respectively); reduces TPA-induced EAr edema (ID50 = 0.357 mg/ear); decreases triglyceride accumulation in the liver and skeletal muscle in high-fat diet-fed KKAy diabetic mice at 100 mg/kg
Cayman Chemical CnabIpIperIdIethnon 10mg
A synthetic CB that binds to the CB receptors CB1 and CB2 with IC50 values of 591 and 968 nM, respectively; intended for forensic purposes and research applications
Cayman Chemical p-nItro-PIfIthrIn-a 10mg
A cell-permeable analog of pifithrin-α that blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-α; suppresses p53-mediated TGF-β1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet
MULTISORB 3G CUT STRIPPAX 2,400/case
This item has a minimum order quantity of 8 cases per supplier requirements.
Cayman Chemical 4-CABhydrochlorIde 10mg
An analog of PCA; inhibits the reuptake of serotonin (IC50 = 330 nM) and dopamine (IC50 = 2.3 μM)
Cayman Chemical D L1ACtoxychavIcol ACTAt 10mg
A natural inhibitor of exportin 1, preventing the export of proteins from the nucleus; reduces several intracellular signaling pathways, including NF-κB, impacting inflammation, cancer, viral replication, and other processes
Cayman Chemical mAIhydrochlorIde 10mg
A psychoactive aminoindan which can be found in recreational drug mixtures; potently inhibits serotonin uptake (IC50 = 212 nM) and stimulates its release without inducing neurotoxicity
Cayman Chemical AcetylLcarnItInd3chLRI 10mg
An internal standard for the quantification of L-acetylcarnitine by GC- or LC-MS
Cayman Chemical PrInomastat 10mg
An inhibitor of MMP-2, -3, -9, -13, and -14 (IC50s = 0.05, 0.3, 0.26, 0.03, and 0.33 nM, respectively); selective for these MMPs over MMP-1 and MMP-7 (IC50s = 8.3 and 54 nM, respectively); reduces tumor growth and inhibits the formation of lung metastases in a murine Lewis lung carcinoma model at 50 mg/kg; reduces the incidence of lung metastasis and tumor microvessel density in an NCI H460 lung cancer orthotopic mouse model at 100 mg/kg; reduces BALF levels of TNF-α and pulmonary edema in a rat model of ventilator-induced lung injury
Cayman Chemical DefensamIde 10mg
An SPHK1 activator; increases S1P levels in primary human keratinocytes but does not affect S1P lyase activity in the same cells at 100 µM; increases protein levels of LL-37 in primary human keratinocytes at 100 µM; inhibits invasion of S. aureus into murine skin ex vivo; has been used as an intermediate in the synthesis of sinuxylamide A as well as compounds with anticancer and antibacterial activities
Cayman Chemical 9-HydroxyelIptIcInhydroch 10mg
An ellipticine derivative with diverse biological activities; inhibits aroclor-induced activation of aniline hydroxylase, aminopyrine N-demethylase, and 7-ethoxycourmarin O-deethylase in rat liver microsomes (Kis = 3.5, 0.6, and 0.74 μM, respectively); inhibits the growth of L1210 murine leukemia cells (IC50 = 3 nM) in vitro and increases survival in an L1210 mouse leukemia model; inhibits carrageenan-induced edema and UV-induced erythema in guinea pigs
Cayman Chemical SuprafenacIn 10mg
An inhibitor of tubulin polymerization (IC50 = 0.38 μM) with anticancer activit; inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM); increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells at 10 μM; reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model at 20 mg/kg
Cayman Chemical HGlyArgpNAhydrochLRIde 10mg
A colorimetric thrombin substrate; cleavage of the GR peptide sequence releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity
Cayman Chemical MozavaptnhydrochlorIde 10mg
A vasopressin V2 receptor antagonist (Ki = 9.42 nM in HeLa cells expressing the human receptor); selective for vasopressin V2 over V1 receptors (IC50s = 14 and 1,200 nM, respectively) in radioligand binding assays using rat kidney and rat liver membranes, respectively; increases urine volume and decreases urine osmolality in rats from 10-30 mg/kg