Custom Peptides
Cayman Chemical ACtyl HexapeptID38trIflu 10mg
A hexapeptide; decreases IL-8 secretion in human keratinocytes when used alone or in combination with acetyl pentapeptide-46
Cayman Chemical DIroxImel Fumarate 10mg
A prodrug form of monomethyl fumarate; undergoes esterase cleavage in the gut to release monomethyl fumarate
Cayman Chemical ARUK2001607 10mg
A PI5P4Kγ inhibitor (IC50 = 0.079 µM for PI5P4Kγ+, a construct with mutations conferring increased functional activity); selectively binds to PI5P4Kγ (Kd = 7.1 nM) over 22 other lipid kinases but does bind to PIP5K1C (Kd = 230 nM); selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >15.8 and >25.1 µM, respectively); selective for PI5P4Kγ over 138 other kinases in a kinase panel and a variety of receptors, enzymes, and ion channels in a safety panel at 10 µM but does inhibit Aurora B kinase and CLK2 by 31 and 37% and dopamine uptake by 59% at 10 µM
Cayman Chemical Esmolol-d7hydrochlorIde 10mg
An internal standard for the quantification of esmolol by GC- or LC-MS
Cayman Chemical 25C-NBOHhydrochlorIde 10mg
A derivative of 2C-C having an N-(2-hydroxybenzyl) addition at the amine; a potent agonist of serotonin receptors that shows selectivity for 5-HT2A over 5-HT2C (EC50s = ~ 0.40 and 15 nM, respectively); intended for forensic and research applications
Cayman Chemical JWH 122 8mthylnaphthyl 10mg
Differs from JWH 122 in that the methyl group is attached to the naphthyl rings at the 8, rather than the 4, position
Cayman Chemical VU6036720hydrochlorIde 10mg
An inhibitor of heteromeric Kir4.1/5.1 channels (IC50 = 0.24 µM); selective for Kir4.1/5.1 channels over a variety of homomeric Kir channels, including Kir4.1 (IC50 = >10 µM), as well as heteromeric Kir3.1/3.2, Kir3.1/3.4, Kir6.2/SUR1, and Kir6.1/SUR2b channels at 30 µM but does inhibit the voltage-gated potassium channel Kv1.1 (IC50 = 6.4 µM); does not inhibit diuresis in mice at 30 and 100 mg/kg due to low oral bioavailability and high hepatic clearance
Cayman Chemical IpsapIronhydrochlorIde 10mg
A partial agonist of serotonin 5-HT1A receptors (Ki = 10 nM in hippocampal membranes); reduces 5-HT release in rat ventral hippocampus in vivo; low doses decrease, while high doses increase, extracellular dopamine release in murine nucleus accumbens; extracellular dopamine levels in murine striatum increase following administration at concentrations >0.1 mg/kg; has anxiolytic effects in vivo, inhibiting foot shock-induced aggression and passive avoidance behavior in rats (ED50s = 2.2 and 0.5 mg/kg, respectively)
Cayman Chemical BofutrelvIr 10mg
An inhibitor of Mpro (IC50 = 0.053 µM in a TR-FRET assay); reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50 = 0.53 µM); reduces viral RNA copy numbers in the same model from 1.85-50 µM
Cayman Chemical UmbelIprenIn 10mg
A prenylated coumarin with diverse biological activities; inhibits 5-LO in a cell-free assay (IC50 = 72.5 nM); active against L. major promastigotes (IC50 = 13.3 µM); induces cell cycle arrest at the G1 phase in, as well as inhibits the growth of (IC50 = 12.5 µM), M4Beu metastatic pigmented melanoma cells; reduces tumor volume in a mouse Lewis lung carcinoma model; reduces tumor growth and the number of metastases in a 4T1 mouse allograft model; reduces carrageenan-induced paw edema in mice at 0.01 mmol/kg
Cayman Chemical DPThydrochlorIde 10mg
A psychedelic drug of the tryptamine class; inhibits the re-uptake of dopamine, serotonin, and norepinephrine (IC50s = 23, 2.9, and 9.1 μM); intended for forensic and research applications
Cayman Chemical BacopasIde II 10mg
A triterpene glycoside; decreases hydrogen peroxide-induced intracellular ROS production and cell death in N2a neuroblastoma cells at 0.4 mg/ml; decreases immobility time in the forced swim and tail suspension tests in mice, indicating anti-depressant like activity, at 50 mg/kg; decreases migration and tube formation in 2H11 and 3B11 cells, as well as HUVECs when used at greater than 15 µM; inhibits the growth of MDA-MB-231, SHG-44, HCT8, A549, and PC3M cancer cells (IC50s = 32.4, 36.9, 40.3, 44.4, and 45.4 µM, respectively)
Cayman Chemical BacopasponIn C 10mg
A triterpenoid saponin with diverse biological activities; inhibits the ATPase activity of P-glycoprotein (IC50 = 57.83 UG/ml); inhibits scopolamine-induced impairments in spatial memory in the Morris water maze and memory retrieval in the step-down test in mice at 50 mg/kg; has antidepressant-like activity in mice; reduces the spleen parasite load in a hamster model of leishmaniasis
Cayman Chemical 1PalmItoyl2ArachIdonylsn 10mg
A phospholipid; has been found in egg yolk and isolated rat retina