Custom Peptides
Cayman Chemical on-7300243 10mg
An LPA1 receptor antagonist (IC50 = 0.16 µM); selective LPA1 over the LPA2 and LPA3 receptors (IC50s = 8.6 and >10 µM, respectively); reduces LPA-induced intraurethral pressure induced by LPA in rats (ID50 = 11.6 mg/kg)
Cayman Chemical 4 MethylnItrosamIno1 3py 10mg
A tobacco-specific nitrosamine carcinogen; metabolites induce DNA alkylation and methylation; increases the protein levels of DNMT1 in mouse bronchial epithelial cells within one day and increases hypermethylation of the tumor suppressor genes Chd13, Prdm2, and Runx3 in lung tissue at a single dose of 100 mg/kg; NNK induces adenomas and adenocarcinomas, which are present after 16 and 50 weeks, respectively, in mouse lung following a single dose of 10 µmol/animal; lifetime administration results in a 90% lung tumor incidence in rats at 63.5 mg/animal
Cayman Chemical 4fluoroaPyrroldInobutIoph 10mg
An analog of 4-MePBP in which a fluorine group is added at the four position of the phenyl ring; intended for forensic and research applications
Cayman Chemical S-3 5-DHPG 10mg
An agonist of the group mGluR, binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors
Cayman Chemical SotIclestat 10mg
A cholesterol 24-hydroxylase/CYP46A1 inhibitor (IC50 = 0.0074 µM); selective for cholesterol 24-hydroxylase over CYP2C8, -2C9, -2D6, -3A4, -1A2, and 2C19 (IC50s = 62, 19, >100, 66, >100, and 14 µM, respectively); reduces seizure frequency and severity and improves survival in a model of Dravet syndrome induced by hyperthermia in Scn1a+/- mice at 0.02% in the diet
Cayman Chemical TermItomycamIde E 10mg
A fatty acid amide from T. titanicus that at 0.1 μg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin
Cayman Chemical 2-PhenthylamInhydrochlorI 10mg
A natural monoamine alkaloid that acts as neuromodulator in the central nervous system; stimulates the release of norepinephrine and dopamine and is metabolized by monoamine oxidases as well as other enzymes; intended for forensic and research applications
Cayman Chemical TermItomycamIde B 10mg
A fatty acid amide from T. titanicus that at 0.1 μg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin
Cayman Chemical VerdIperstat 10mg
An irreversible inhibitor of MPO (IC50 = 630 nM); selective for MPO over a panel of 130 enzymes, transporters, and ion channels (IC50s = >50 µM for all); reduces MPO expression, prevents an increase in neuronal loss, and prevents decreases in motor score and stride length in a PLP-αSYN transgenic mouse model of multiple system atrophy at 180 µmol/kg, p.o.
Cayman Chemical SynthetIc HIspIdol 10mg
An aurone with diverse biological activities; is an inhibitor of tyrosinase, MAO-A, and MAO-B (IC50s = 38.4, 0.26, and 2.45 µM); increases catalase and SOD activity in cell-free assays, as well as decreases intracellular ROS in, and increases the lifespan of, C. elegans at 50 µM; decreases immobility time in forced swim and tail suspension tests in mice at 2, 5, and 15 mg/kg
Cayman Chemical BIctegravIrsodIum salt 10mg
An HIV-1 integrase inhibitor (IC50 = 7.5 nM for strand transfer activity); has antiviral activity against clinical isolates of HIV-1 in PBMCs (EC50s = 0.04-1.7 nM); inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively)
Cayman Chemical RactopamInd3hydrochLRIde 10mg
An internal standard for the quantification of ractopamine by GC- or LC-MS
Cayman Chemical SLF1081851hydrochlorIde 10mg
An inhibitor of SPNS2; inhibits mouse Spns2 by 67% at 2 µM; inhibits S1P export from HeLa cells expressing mouse Spns2 (IC50 = 1.93 µM); decreases blood lymphocyte numbers and plasma S1P levels in mice at 20 mg/kg
Cayman Chemical AMARA PeptIDtrIfluoROCTA 10mg
A peptide substrate for AMPK; has been used to monitor AMPK activity in vitro and in vivo
Cayman Chemical SynthetIc ButIn 10mg
A flavanone with diverse biological activities; induces melanogenesis in B16/F10 melanoma cells at 1 µM; decreases cytochalasin B-induced DNA damage in isolated human peripheral blood lymphocytes from 1-4 UG/ml; inhibits implantation and decreases the number of pups when administered to pregnant rats from 5-20 mg/animal; increases uterine weight in ovariectomized rats at 0.5 mg/animal