Custom Peptides
Cayman Chemical CP 93 129hydrochlorIde 10mg
A 5-HT1B receptor agonist; selectively binds 5-HT1B over 5-HT1A, 5-HT1C, 5-HT1D, and 5-HT2 (Kis = 0.0081, 1.5, 2.9, 1.1, and 7.2 µM, respectively); inhibits potassium-induced GABA release from rat globus pallidus slices at 5.4 µM; reverses reserpine-induced akinesia in a rat model of Parkinson's disease at 110 and 220 nmol/animal; reduces food intake in rats when infused into the pons parabrachial nucleus or the PVN of the hypothalamus (ED50s = 1 and 50 nmol, respectively); reduces the frequency of pursuits, tail rattles, threats, and attack bites in a resident-intruder test in mice
Cayman Chemical -ncrostatIn-2 10mg
A RIPK1 inhibitor; 6 mg/kg/day prevents TNF-induced mortality in a murine model of SIRS; decreases irradiation-induced LDH release and cell death in murine embryonic Cyt c-/- cells; 1.6 mg/kg/day prevents angiotensin II-induced elastin degradation and aortic inflammation in a murine AAA model
Cayman Chemical HomosIldenafIl 10mg
A PDE5 inhibitor (IC50 = 8.9 nM); has been found as an adulterant in dietary supplements for erectile dysfunction
Cayman Chemical LevobupIvacaInd9hydrochlo 10mg
An internal standard for the quantification of levobupivacaine by GC- or LC-MS
Cayman Chemical -Glu-AlatrIfluoroACTAte500mg
A dipeptide; has been found in P. roqueforti; has been found in ripened Gouda, goat, and Milner cheeses; a positive allosteric modulator of CaSR (EC50 = 4.8 µM in CaSR-expressing HEK293 cells); induces glutathionuria in mice at 4 mmol/kg; plasma levels are increased in malnourished neonatal mice; increased serum levels are positively associated with an increased risk of chronic kidney disease
Cayman Chemical 17phenl trInor ProstglndI 10mg
An isopropyl ester of the free acid PG which corresponds to bimatoprost; a potent ocular hypotensive agent, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost, but with significantly more irritation
Cayman Chemical 4-bromo-2 5-DmA 10mg
A designer drug patterned after 2,5-dimethylamphetamine compounds; intended for forensic and research purposes
Cayman Chemical GlecaprevIr 10mg
An HCV NS3/4A protease inhibitor; inhibits NS3/4A from HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a (IC50s = 4.6, 8.9, 3.5, 3.8, 7.9, 6.1, 8.1, and 11.3 nM) in cell-free assays but does not inhibit human chymase, chymotrypsin type II, chymotrypsin type VII, elastase, kallikrein, urokinase, or cathepsin B proteases (IC50s = >200,000 nM); inhibits HCV replication in stable Huh7-derived replicon cell lines infected with subgenomic genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a (EC50s = 0.85, 0.94, 2.2, 4.6, 1.9, 2.8, 1.4, and 0.86 nM, respectively); inhibits replication of clinical isolates of genotypes 1a (EC50s = 0.05-0.12 nM), 1b (EC50s = 0.20- 0.68 nM), 2a (EC50s = 0.66- 1.9 nM), 2b (EC50s = 1.4- 3.2 nM), 3a (EC50s = 0.71- 3.8 nM), and 4a (EC50s = 0.31- 0.55 nM)
Cayman Chemical DorsomorphInhydrochlorIde 10mg
A potent, reversible inhibitor of AMPK (Ki = 109 nM); dose-dependently inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK6); downregulates the Akt/mTOR pathway to induce autophagy in U251 human glioma cells
Cayman Chemical L-Sulforaphen 10mg
A natural isothiocyanate that has antioxidant, anti-inflammatory, and anti-carcinogenic effects
Cayman Chemical 9-HydroxyelIptIcInhydroch 10mg
An ellipticine derivative with diverse biological activities; inhibits aroclor-induced activation of aniline hydroxylase, aminopyrine N-demethylase, and 7-ethoxycourmarin O-deethylase in rat liver microsomes (Kis = 3.5, 0.6, and 0.74 μM, respectively); inhibits the growth of L1210 murine leukemia cells (IC50 = 3 nM) in vitro and increases survival in an L1210 mouse leukemia model; inhibits carrageenan-induced edema and UV-induced erythema in guinea pigs
Cayman Chemical CefdItren PIvoxIl 10mg
A prodrug form of cefditoren; effective against systemic S. aureus, E. coli, K. pneumoniae, P. mirabilis, or S. marcescens infections in mice (ED50s = 10, 2.5, 11, 4.4, and 11 mg/kg, respectively)
Cayman Chemical BIsIndolylmaleImID VIIIAC 10mg
A selective PKC inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC; exhibits PKC isozyme specificity with preference for PKCα over PKCβI, PKCβII, PKCγ, or PKCε (IC50s = 53, 195, 163, 213, and 175 nM, respectively)