Custom Peptides
Cayman Chemical Phenylpiracetam 10mg
A nootropic derivative of the GABAergic agent piracetam that has been evaluated for its efficacy in reducing neurological deficits related to cerebral ischemia, epilepsy, and neurobehavioral disorders; intended for research and forensic purposes only
Cayman Chemical EntecavIrhydrate 10mg
An antiviral nucleoside analog and inhibitor of HBV reverse transcriptase (IC50 = 0.5 nM); reduces virion DNA in the culture supernatant of HepG2 2.2.15 cells infected with HBV (EC50 = 3.75 nM); reduces serum and hepatic levels of viral DNA in a duckling model of HBV infection at 1 mg/kg
Cayman Chemical TelotrIstat EtIprate 10mg
A prodrug form of telotristat; reduces levels of 5-HT in mouse jejunum and blood at 15-300 mg/kg; inhibits increases in IL-1β and IL-6 levels, histological damage in the colon, and weight loss in a mouse model of trinitrobenzene sulfonic acid-induced colitis at 200 mg/kg; reduces colonic levels of MPO, IL-1β, and IL-17, as well as worm burden, in mice infected with T. muris at 300 mg/kg
Cayman Chemical TamsulosInhydrochlorIde 10mg
A potent α1-AR antagonist (Ki = 0.229 nM in a radioligand binding assay); 3,800-fold selective for α1-ARs over α2-ARs (Ki = 871 nM); antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA2 = 10.11) but has no effect on contraction stimulated by histamine, serotonin, angiotensin II, or prostaglandin F2α; reverses the phenylephrine-induced pressor effect in pithed rats; reversibly reduces fertility in male rats when administered at a dose of 0.15 mg/kg; reduces prostatic pressure in a dose-dependent manner with minimal hypotensive effects in anesthetized dogs
Cayman Chemical MoexIprIlat 10mg
An ACE inhibitor and active metabolite of the prodrug moexipril (IC50 = 2.1 nM); prevents the estrone- or angiotensin II-stimulated proliferation of primary neonatal rat cardiac fibroblasts at 10 nM; reduces mean arterial blood pressure and increases the levels of atrial natriuretic peptide in ovariectomized mice at 50 mg/kg per day
Cayman Chemical NundecnoylLHomoserIn lac 10mg
A bacterial quorum-sensing signaling molecule; induces GFP production in E. coli expressing the V. fischeri LuxR-PluxI quorum-sensing operon from 100-1,000 nM; inhibits concanavalin A-induced proliferation of isolated mouse splenocytes (IC50 = 90 µM)
Cayman Chemical IdarubIcInhydrochlorIde 10mg
A 4-demethoxy analog of daunorubicin which intercalates in DNA and inhibits topoisomerase II, resulting in cancer cell cytotoxicity at low concentrations (IC50 = 20-120 nM); effective in combination therapy for the treatment of different types of leukemia
Cayman Chemical CID-2745687 10mg
A reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a Ki of 12.8 nM; less potently blocks activation of GPR35 by zaprinast (IC50 = 160 nM); shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC50 = 9.08 µM)
Cayman Chemical TIvoznIbhydrate 10mg
An orally available, selective VEGFR inhibitor (IC50s = 0.21, 0.16, and 0.24 nM for VEGFR1, VEGFR2, and VEGFR3, respectively); also inhibits c-Kit and PDGFRβ (IC50s = 1.63 and 1.72 nM, respectively)
Cayman Chemical ReparIxInL-LysIn salt 10mg
A non-competitive allosteric inhibitor of IL-8/CXCL8 activation of CXCR1 and CXCR2 chemokine receptors (IC50s = 1 and 100 nM, respectively); blocks IL-8-induced leukocyte recruitment (IC50 = 1 nM) and other inflammatory responses, without affecting receptor activation induced by other CXCR1 and CXCR2 agonists; at 100 nM, depletes a cancer stem cell population in human breast cancer cell lines in vitro
Cayman Chemical Methyl 2 1HIndazole3carbo 10mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; a precursor in the synthesis of synthetic cannabinoids including AMB, 5-fluoro AMB, MMB-4en-PINACA, MMB-FUBINACA, and MA-CHMINACA; a metabolite of 5-fluoro AMB and MA-CHMINACA; intended for research and forensic applications
Cayman Chemical AcrIdIn Ornge 10-nonylbro 10mg
A mitochondrial dye; incorporates into the cardiolipin-rich inner mitochondrial membrane; selectively binds to cardiolipin-containing liposomes over phosphatidylserine- and phosphatidylinositol-containing liposomes in vitro (Kas = 0.002, 7,000, and 7,000 mM, respectively); binding dependent on mitochondrial membrane potential; ex/em = 490/510 nm, respectively; has been used to quantify cardiolipin content and mitochondrial mass in isolated mitochondria and cellular systems
Cayman Chemical D-Mnose-6-PhosphatesodIum 10mg
A phosphorylated aldohexose that can be used to produce glucose, mannitol, or N-glycans; also a ligand for both cation-dependent and -independent receptors and binds, as part of an N-glycan, to MRH domains on other proteins