Custom Peptides
Cayman Chemical Boswellic ACD 10mg
A pentacyclic triterpene with diverse bioactivities; inhibits 5-LO (IC50 = ~5 µM); inhibits cell proliferation in HL-60 cells (IC50s = 3.7, 7.1, and 6.3 µM for DNA, RNA, and protein synthesis, respectively); increases nitric oxide and phosphorylation of eNOS in HUVECs deprived of oxygen and glucose; increases calcium mobilization in platelets (≥3 µM); induces platelet aggregation (EC50 = 8 µM)
Cayman Chemical Dehydro AmlodIpInfumarate 10mg
A potential impurity found in commercial preparations of amlodipine; a degradation product formed during storage or when amlodipine is subjected to oxidative or acidic conditions or undergoes photo or electrochemical degradation
Cayman Chemical Cholyl-putrescIn 10mg
A polyamine bile amidate; has been found in lion and mouse, as well as serval, cheetah, and tiger fecal samples; has been used as a standard for the detection of endogenous bile acid amidates in mammalian intestinal and fecal samples
Cayman Chemical NDT 9513727 10mg
A competitive antagonist of C5aR (IC50 = 11.6 nM for the human recombinant receptor); has inverse agonist activity; selective for human recombinant over rat and mouse recombinant C5aRs (IC50 = >10 µM for both) but does have activity at macaque and gerbil receptors (IC50s = 7.3 and 6.4 nM, respectively); inhibits degranulation in C5a-stimulated U937 cells (IC50 = 7.1 nM); prevents C5a-induced neutropenia in gerbils (ED50 = 2.2 mg/kg) and in cynomolgus macaques at 5 and 25 mg/kg
Cayman Chemical 4NItrophenyl aLrhamnopyrn 10mg
A colorimetric naringinase substrate; upon hydrolysis by the α-rhamnosidase subunit of naringinase, 4-nitrophenol is released which can be quantified by colorimetric detection at 405 nm as a measure of naringinase α-rhamnosidase activity; has been used in the detection of naringinase α-rhamnosidase activity in various bacteria
Cayman Chemical ArnbIa sInsIs AlknIn 10mg
A naphthoquinone with diverse biological activities; enantiomer of shikonin; selectively inhibits tumor-specific PKM2 (IC50 = 0.3 μM) over PKM1 and PKL; inhibits proliferation of HCT116 and SW480 colorectal cancer cells (IC50s = 2.38 and 4.53 μM, respectively); halts the cell cycle at the G1 phase and induces apoptosis in HCT116 cells at 3 μM; increases levels of Hsp70 in untreated and UVB-irradiated HaCaT cells as well as inhibits UVB-induced DNA fragmentation and caspase-3 activity in HaCaT cells at 1 μM; active against methicillin-sensitive and -resistant S. aureus (MICs = 6.25 μg/ml) as well as vancomycin-sensitive and -resistant E. faecalis (MICs = 50 and 25 μg/ml, respectively); scavenges DPPH radicals in a cell-free assay (EC50 = 22 ppm)
Cayman Chemical Black Tea TheaflavIn 10mg
A polyphenolic flavonoid with antioxidant and anticancer activities; scavenges singlet oxygen and hydrogen peroxide as well as superoxide and hydroxide radicals in vitro (IC50s = 0.73, 0.49, 14.5, and 38.0 µM, respectively); inhibits the growth of OVCAR-3 and A2780/CP70 human ovarian cancer cell lines, but not the ovarian epithelial cell line IOSE 364 (IC50s = 11.9, 38.5, and >40 µM, respectively)
Cayman Chemical ElagolIxsodIum salt 10mg
An antagonist of GnRHR (Ki = 0.9 nM in a radioligand binding assay); selective for GnRHR over CYP3A4 (IC50 = 56 μM) as well as a panel of 100 receptors, ion channels, enzymes, and transporters (IC50s = >10 μM); inhibits GnRH-induced inositol phosphate production in RBL-1 cells expressing human GnRHR (IC50 = 1.5 nM); suppresses production of luteinizing hormone in castrated male cynomolgus macaques at 30 mg/kg
Cayman Chemical XamoterolhemIfumarate 10mg
A β1-adrenergic receptor partial agonist (EC50 = 80 nM for the generation of cAMP in neonatal rat cardiomyocyte cultures); increases spontaneous contraction of isolated rat right atria (EC50 = 4.67 nM); increases heart rate in beagle dogs (ED50 = 3.2 UG/kg) and a rat model of spontaneous heart failure (ED50 = 6 UG/kg)
Cayman Chemical zngbs zoma cns 8Sogaol 10mg
A polyphenol with diverse biological activities; inhibits TAK1 (IC50 = 5.027 nM); inhibits COX-2 (IC50 = 32 µM); reduces IL-17-induced secretion of IL-8 from SW 982 sarcoma cells and Tnf-α from RAW 264.7 macrophages at 10 µM; decreases TNF-α-induced secretion of IL-6, IL-8, and CCL2 by, and reduces IL-17-induced migration and invasion of, primary human rheumatoid arthritis fibroblast-like synoviocytes at 5 or 10 µM; inhibits PMA-induced migration and invasion of MDA-MB-231 cancer cells at 10 µM; reduces paw thickness, as well as adjuvant-induced increases in joint space, synovial tissue proliferation, and cartilage damage, and improves gait without reducing body weight in a rat model of AIA at 30 mg/kg every three days
Cayman Chemical Solamargn 10mg
A glycoalkaloid with anticancer activity; decreases viability of H1650, H1975, PC-9, A549, and H1299 NSCLC cells at 6 µM; reduces tumor growth in an A549 mouse xenograft model at 8 mg/kg per day
Cayman Chemical AsIatIcosIde 10mg
The main saponin constituent of C. asiatica that has been shown to improve wound healing including increasing collagen synthesis and elevating antioxidant levels in various normal and diabetic wound models
Cayman Chemical AconItum SongorIn 10mg
A diterpene alkaloid with diverse biological activities; an antagonist of the GABAA receptor (IC50 = 7.06 µM in rat brain membranes); reduces the viability and migration of, and induces apoptosis in, SKOV3 and A2780 epithelial ovarian cancer cells at 20-80 µM; reduces tumor growth in a SKOV3 mouse xenograft model at 0.25 and 2.5 mg/kg; prevents and inhibits paw edema in a mouse model of carrageenan-induced inflammation at 0.025 mg/kg; has antinociceptive activity in the EArly phase of the formalin test in mice at 46.4 mg/kg