Custom Peptides
Cayman Chemical AlexIdInhydrochlorIde 10mg
An alkyl bis(biguanide) antiseptic which kills plaque forming microorganisms; binds to LPS and LTA and inhibits fungal phospholipase B (IC50 ~ 250 nM); inhibits the mitochondrial phosphatase PTPMT1 (IC50 = 1.08 μM, in vitro) and induces apoptosis in cancer cell lines (ED50 = 1.8-2.6 μM)
Cayman Chemical NorursodeoxycholIc AcId 10mg
A bile acid; is secreted in an unchanged form, as trihydroxy derivatives, or as sulfate or glucuronide conjugates; decreases serum levels of ALT and alkaline phosphatase, periductal fibrosis, and hepatic hydroxyproline content in an Mdr2-/- mouse model of sclerosing cholangitis at 0.5% w/w in the diet
Cayman Chemical JWH 018 5hydroxyIndl meta 10mg
A major urinary metabolite of JWH 018; intended for research and forensic applications
Cayman Chemical 2EthylethcathInonhydrochl 10mg
A substituted cathinone with potential for abuse; intended for forensic and research applications
Cayman Chemical MetaprIston 10mg
An active metabolite of mifepristone; an antagonist of human glucocorticoid and progesterone receptors with relative affinities of 61 and 21%, respectively, compared to mifepristone; decreases the proliferation of A375 and B16/F10 cells (IC50s = 57.4 and 75.8 µM, respectively); induces cell-cycle arrest at the G1 phase in B16/F10 cells at 80 µM; decreases the number of lung metastases in a B16/F10 murine model of lung metastasis at 2.5, 10, and 50 mg/kg per day
Cayman Chemical 1Naphthyl 3 5DNItrobenzAT 10mg
A dual 5-LO and mPGES-1 inhibitor (IC50s = 1 and 3.6 µM, respectively)
Cayman Chemical TetrahydrocurcumIn 10mg
A metabolite of curcumin with diverse biological activities; scavenges DPPH radicals in a cell-free assay (EC50 = 16.8 μM); inhibits LPS-induced increases in iNOS and COX-2 expression in RAW 264.7 cells at 50 µM; inhibits LPS-induced increases in TNF-α release at 100 µM; inhibits LPS-induced increases in NO production and IL-6 levels in a concentration-dependent manner; reduces carrageenan-induced paw edema in rats (ED50 = 20 mg/kg); reduces the formation of neocapillaries and decreases microvascular density as well as VEGF, VEGFR2, and HIF-1α expression in a CaSki cervical cancer nude mouse xenograft model at 100, 300, and 500 mg/kg
Cayman Chemical 7fluoro TryptamInhydrochl 10mg
A tryptamine derivative that potentially agonizes 5-HT serotonin receptors; intended for research and forensic applications
Cayman Chemical Nacetyl2 3dehydro2Deoxyn 10mg
An inhibitor of human neuraminidases (IC50s = 143, 43, 61, and 74 μM, for NEU 1, 2, 3, and 4, respectively); reduces latency to first seizure and increases seizure duration in a rat model of potassium-induced seizures
Cayman Chemical nsamItocIn P-3 10mg
A microtubule depolymerizing agent that binds tubulin (Kd = 1.3 µM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation
Cayman Chemical 4-fluoro PV9hydrochlorIde 10mg
Differs from PV9 by having a fluorine atom at the four, or para, position of the phenyl group
Cayman Chemical L-NmAcItrate 10mg
L-NMMA is a relatively non-selective inhibitor of all NOS isoforms. It is the archetypal NOS inhibitor to which other inhibitors are most often compared.{5433} The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.{1415,5648}