Custom Peptides
Cayman Chemical CyclovIrobuxIn D 10mg
An alkaloid with diverse biological activities; ERG channel blocker (IC50 = 19.7 μM using whole-cell patch-clamp electrophysiology in HEK293 cells expressing the human receptor); increases the amount and rate of calcium release from intracellular stores in healthy neonatal rat cardiac myocytes and those isolated from adult rats with heart failure in a concentration-dependent manner; increases expression of Ryr2 and Serca2a and decreases expression of Ncx; reduces mortality and improves cardiac function in a rat model of congestive heart failure; inhibits doxorubicin-induced myocardial apoptosis and mitochondrial cytochrome C release in mice when preadministered at a dose of 1mg/kg per day for four days; induces cellular autophagy and inhibits growth of MCF-7 breast cancer cells and induces mitochondrial apoptosis in MGC803 and MKN26 gastric cancer cells
Cayman Chemical 12-keto LIthocholIc AcId 10mg
A metabolite of DCA; fecal levels are elevated in rats fed a diet supplemented with cholic acid or DCA compared with rats fed a control diet or a diet supplemented with cholesterol, HDCA, or LCA; activates the human PXR (EC50 = 31.3 μM in a cell-based transactivation assay); levels are increased in duodenal bile from patients with type 2 diabetes
Cayman Chemical 3 5-DIcaffeoylquInIc AcId 10mg
A natural phenolic compound that has antioxidant, anti-inflammatory, and antiviral biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 71.8 μM); inhibits superoxide production in fMLF- and cytochalasin B-activated human neutrophils (IC50 = 1.92 μM); inhibits HIV-1 integrase 3’-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively); inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml); protects mice from LPS-induced acute lung injury and decreases neutrophil count in BALF at 25 mg/kg
Cayman Chemical AlopurInol RIbosIde 10mg
A ribonucleoside; inhibits Leishmania promastigote growth and prevents amastigote maturation into promastigotes; prevents mortality in mouse models of T. cruzi infection at 239, 511, and 929 mg/kg per day
Cayman Chemical EtIocholndIon 10mg
A neurosteroid; inhibits IGly in isolated rat hippocampal pyramidal neurons at 50 µM; inhibits glucose exchange transport in isolated human erythrocytes at 0.1, 0.3, and 0.5 mM
Cayman Chemical IsorhamntIn 3OnohesperIdo 10mg
A flavonoid glycoside with antioxidant and osteoclastogenic activities; inhibits XO and scavenges superoxide radicals in a cell-free assay (IC50s = 48.75 and 30 UG/ml, respectively); promotes RANKL-induced osteoclastogenesis of mouse bone marrow-derived macrophages
Cayman Chemical nrIdronIc AcId 10mg
An amino bisphosphonate that inhibits FPP synthase (IC50 = 388.2 nM in a cell-free assay); reduces the number of RAW 264.7 cells expressing TRAP in an in vitro model of osteoclastogenesis induced by co-culture with CRL-12257 osteoblasts from 0.001-100 µM; inhibits FGF2-induced proliferation and tube formation in HUVECs at 30 µM; reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats at 0.1 mg/kg per day s.c.
Cayman Chemical GBR 12909hydrochlorIde 10mg
A potent inhibitor that blocks dopamine uptake (IC50 = 1-51 nM); effectively inhibits dopamine uptake in vivo, leading to consequent stimulation of dopamine receptors.
Cayman Chemical 13-MethylberberInchlorIde 10mg
A 13-methyl-substituted derivative of berberine; has antibacterial, anti-inflammatory, anti-obesity, and hypercholesterolemic activity; has improved antibacterial activity against S. aureus (MIC = 125 UG/ml) and improved antitumor activity compared to berberine; induces down-regulation of adipocyte differentiation transcription factors; reduces de novo lipid synthesis
Cayman Chemical CntharIdIc AcIdodIum salt 10mg
A PP1 and PP2A inhibitor with IC50 values of 0.6 and 0.05 µM, respectively
Cayman Chemical PTI-125hydrochlorIde 10mg
A purported binding agent of filamin A; the data regarding PTI-125 have prompted expressions of concern by the journals in which the data were published
Cayman Chemical WRW4trIfluoroacetate salt 10mg
A peptide antagonist of FPR2 (IC50 = 0.23 µM) and FPR3; inhibits increases in intracellular calcium and chemotaxis induced WKYMVm in RBL-2H3 cells expressing FPR2 and by F2L in isolated human monocytes at 10 µM; prevents Aβ42-induced production of superoxide in isolated human neutrophils at 10 µM; increases lung edema and BALF protein levels in the absence and presence ceftriaxone in a mouse model of acute lung injury induced by S. pneumoniae at 1 mg/kg