Drug Discovery Research Screening Libraries
Selleck Chemical LLC Natural Product Library 100uL/well
A unique collection of 2616 natural products for high throughput screening (HTS) and high content screening (HCS). *For Research & Development use only. Product is not intended for drug, household, or human consumption.
AdipoGen Cholesteryl acetate
Chemical. CAS 604-35-3. Formula C29H48O2. MW 428.69. Synthetic. Cholesteryl acetate is a normal human cholesteryl ester present in diverse fluids and organs. Cholesteryl acetate is also present in foods. Food oxidation affects the quality and safety of the human diet by generating compounds with biological activities that can adversely affect health. In particular the susceptibility of cholesterol to oxidation is well known, certain products of cholesterol oxidation have been reported to produce cytotoxic, angiotoxic and carcinogenic effects. Cholesteryl ester CE is the major transport and storage form of cholesterol in lipoprotein particles and most cell types. Molecular composition of CE species is of high interest for arteriosclerosis research, i. e. as components of lipoprotein subclasses or in studies investigating the mechanisms involved in the generation of lipid laden foam cells.
AdipoGen Cholesterol
Chemical. CAS 57-88-5. Formula C27H46O. MW 386.65. Synthetic. Major component of all biological membranes. Essential structural component of mammalian cell membranes and required to establish proper membrane permeability and fluidity. In addition to its importance within cells, also serves as a precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D. Regulates the function of the transporters and signaling proteins present on the plasma membrane. Implicated in cell signaling processes, assisting in the formation of lipid rafts in the plasma membrane, which brings receptor proteins in close proximity with high concentrations of second messenger molecules. Used to prepare immune-stimulating complexes to enhance cellular and humoral responses and suitable for use in liposome preparations. Binds to and affects the gating of a number of ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel.
Cytek Biosciences Inc Autophagy LC3 Detection Am
Product Name: Guava Autophagy LC3 Antibody-Based Detection Kit
Cytek Catalog Number: FCCH100171
Product Class: Guava Muse Reagent
Type: easyCyte
Size: 100 Tests
Cytek Biosciences Inc PI3K MAPK Dual Activation
Product Name: Muse PI3K/MAPK Dual Pathway Activation Kit
Cytek Catalog Number: MCH200108
Product Class: Guava Muse Reagent
Type: Muse
Size: 50 Tests
AdipoGen Helvolic acid
Chemical. CAS 29400-42-8. Formula C33H44O8. MW 568.7. Isolated from Aspergillus fumigatus Strain WDMH-35. Steroidal triterpene. Antibiotic. Antibacterial. Shows broad activity against Gram positive and negative bacteria. Mycotoxin. Antifungal. Antitumor agent. Cytotoxic against different human cancer cells. Antituberculosis agent. Oxidized LDL uptake inhibitor. Phytotoxin. Inhibitor of the protein biosynthesis through archeal elongation factor 2 EF-2.
AdipoGen Rosiglitazone maleate
Chemical. CAS 155141-29-0. Formula C18H19N3O3S . C4H4O4. MW 357.4 . 116.1. Same activities as rosaglitazone Prod. No. AG-CR1-3570 but different formulation. Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor gamma PPAR-gamma agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and vascular function. Enhances proliferation of endogenous neural progenitor cells NPCs. Anti-inflammatory compound. Has controversial therapeutic effects on the cardiovascular system. Promotes adipocyte differentiation of mesenchymal stem cells MSCs.
AdipoGen NMNAT1 hHishighly active
Protein. Human full-length NMNAT1 aa 1-279 is fused at the N-terminus to a His-tag. Source E. coli. Endotoxin content N/A. Liquid. In 50mM sodium phosphate, pH8.0, containing 300mM sodium chloride, 2mM DTT and 10% glycerol. Purity >95% SDS-PAGE. Nuclear NMNAT isoform. Catalyzes the formation of NAD from nicotinamide mononucleotide NMN and ATP. It can also use the deamidated form of nicotinic acid mononucleotide NAMN as substrate with the same efficiency. Interacts with PARP-1/ARTD1. Protects against axonal degeneration following mechanical or toxic insults. Widely expressed.
AdipoGen Amastatin hydrochloride
Chemical. CAS 100938-10-1. Formula C21H38N4O8 . HCl. MW 474.6 . 36.5. Synthetic. Slow, tight binding and competitive aminopeptidase AP inhibitor. Inhibits cytosolic leucine aminopeptidase, microsomal aminopeptidase M and bacterial leucine aminopeptidase, human serum aminopeptidase A AP-A, aminopeptidase N AP-N, tyrosine aminopeptidase, but not aminopeptidase B AP-B. Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin or thermolysin. Inhibits completely the Suc-Ala-Ala-Pro-Leu-pNA amidolytic enzyme. Slightly inhibits the formation of angiotensin III Ang III from Angiotensin II through AP-A, but significantly increases the potency of angiotensin III and-angiotensin I. Moderate inhibitor of mitochondrial intermediate peptidase MIP. Weak inhibitor of simian immunodeficiency virus protease SIV-PR.
AdipoGen 7-Diethylamino-4-methylcoumari
Chemical. CAS 91-44-1. Formula C14H17NO2. Molecular Weight 2932.29. 7-Diethylamino-4-methylcoumarin also called Coumarin 1 or Coumarin 460 is a bichromophoric fluorescent laser dye. It can be used as a laser dye, a luminescent phosphor in LEDs, a luminescent probe and sensor in biological applications, and a fluorescer in rewritable optical drives. The efficient fluorescent property of this compound is utilized to sense the Pd2 selectively and sensitively.It is also used as a fluorescent whitening agent FWAs, which is a chemical added to fabrics and paper during manufacture to increase whiteness and brightness. Spectral data lambdaex 373nm ethanol lambdamax 460nm Laser range 450-484nm.
AdipoGen 4-Methylumbelliferyl nonanoate
Chemical. CAS 18319-93-2. Formula C19H24O4. MW 316.39. Synthetic. Non-fluorescent lipase substrate conjugated with 4-methylumbelliferone. After lipolytic hydrolysed the highly fluorescent 4-methylumbelliferone is released and emitts strongly at 485 nm blue fluorescence ex = 366 nm.
AdipoGen Pioglitazone
Chemical. CAS 111025-46-8. Formula C19H20N2O3S. MW 356.4. Thiazolidinedione TZD reference compound. Selective PPARgamma agonist. Selectively activates PPARgamma-1. Anti-diabetic , decreasing insulin resistance in adipose tissue. Is about one tenth as potent as rosiglitazone. Lipid metabolism modulator. Estrogen synthesis inhibitor. NF-kappaB inhibitor. Neuroprotective.