Nucleotides
Indofine Chemical (+/-)-Jasmonic Acid, 100 Mg
JASMONIC ACID, Products for Life Science, 221682-41-3, 100 mg
Apexbio Technology LLC SpCas9 mRNA (ARCA 5mCTP ψUTP) 1mg (1mg/mL)
SpCas9 mRNA (ARCA 5mCTP UTP) encodes Streptococcus pyogenes Cas9 (SpCas9) protein This product can be used with purified guide RNA (gRNA) sequences in the CRISPR/Cas system for recognizing and cleaving genomic DNA targets CRISPR/Cas a defense system has been adapted from the Type II CRISPR/Cas system of S pyogenes for eukaryotic gene editing It requires two key components the Cas9 endonuclease and a non-coding gRNA Guided by a single gRNA Cas9 introduces DNA double-strand breaks (DSBs) at specific genomic sites Cells activate endogenous DNA repair pathways non-homologous end joining (NHEJ) or homology-directed repair (HDR) to repair the targeted DSB SpCas9 mRNA (ARCA 5mCTP UTP)is designed to mimick mature eukaryotic mRNA It contains a cap 0 structure generated via co-transcriptional capping Incorporation of modified nucleotides 5mCTP UTP poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vivo
Cayman Chemical 7-Deaza-7-Iodo-2-deoxygunos 1g
A nucleoside derivative; has been used as an intermediate in the synthesis of fluorescent nucleotide derivatives for incorporation into single- or double-stranded oligonucleotides
Medchemexpress LLC Cytidine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2',2'-difluoro- (trisodium) | 99.2% | 569.08 | 5 MG
Gemcitabine triphosphate (dFdCTP) trisodium is the active metabolite of Gemcitabine, known for its cell-killing mechanism that involves competition with cytidine triphosphate during DNA replication, thereby inhibiting chain elongation. It partially inhibits dCMP deaminase and serves as a substrate for DNA synthesis, incorporating into cellular DNA and RNA. This leads to disruption of DNA and RNA synthesis, cell cycle arrest in G0/G1 and S phases, induction of apoptosis, and reduction of tumor cell proliferation. It is utilized in research for pancreatic cancer and non-small cell lung cancer.
- Inhibits replicative DNA polymerases α and ε
- Reduces cell viability in cancer cells
- Arrests cell cycle in S phase
- Induces caspase-3/7 activation
- Exerts antitumor effects in xenograft models
- Shows potent anti-tumor efficacy through caspase-dependent apoptosis
Cayman Chemical AdenosIn 5- -thIo-trIphos 5mg
A stable analog of ATP that acts as a potent agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC50 = 5.52 for P2Y11)
Medchemexpress LLC D-Ribose 5-phosphate disodium dihydrate | 207671-46-3 | >99.0% | 310.10 | 100 MG
D-Ribose 5-phosphate disodium dihydrate is an intermediate of the oxidative branch of the pentose phosphate pathway (PPP) and an end product of the nonoxidative branch of the PPP. It is used in the synthesis of nucleotides and nucleic acids. Ribose-5-phosphate is generally assumed to arise via the oxidative and nonoxidative pentose phosphate pathways.
- Endogenous metabolite
- For research use only
- Not sold to patients
Chem-Impex International, Inc. Adenine | 73-24-5 | MFCD00041790 | 1KG
Adenine, 73-24-5, MFCD00041790, 1KG
Cayman Chemical N6-MethyladenIn 250mg
A modified purine that is commonly found in genomes of prokaryotes, protists, and plants
Cayman Chemical AdenosIn 5-dIphosphate 250mg
A central component of energy storage, metabolism, and signal transduction in vivo; a precursor for ATP and agonist of purinergic receptors
Enzo Life Sciences 8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate . sodium salt (5mg). CAS: 51239-26-0
Selective activator of cGMP-dependent protein kinase (PKG) Iα, Iβ, and type II as well as of cGMP-gated ion channels. Higher activation potential as compared to cGMP; excellent cell membrane permeability and phosphodiesterase stability. Preferred alternative to unsuitable analogs such as dibutyryl-cGMP. Alternative name: 8-pCPT-cGMP . Na. Purity: ≥99% (HPLC). Solubility: Soluble in water. Long Term Storage: -20°C.
Invivogen 2'3'-cGAMP Control, 1 mg
2’3’-cGAMP Control, also known as 2’5’-GpAp, is a linear dinucleotide analog after hydrolysis of cyclic guanosine monophosphate- adenosine monophosphate (2’3’-cGAMP) by phosphodiesterases.
Research Products International Corp Uracil, 25 G
- CAS Number: 66-22-8
- Molecular Formula: C4H4N2O2
- Molecular Weight: 112.09