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Nucleotides are composed of a nitrogenous base covalently bound to a 5-carbon sugar molecule and one or more phosphate functional groups. They are the molecules that make up the structural units of DNA and RNA.
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7-Deaza-7-Propargylamino-dATP is a chemically modified nucleotide analog derived from deoxyadenosine triphosphate It is designed to enable enzymatic incorporation by DNA polymerases during DNA synthesis thereby facilitating site-specific labeling of DNA 7-Deaza-7-Propargylamino-dATP exerts its biological activity primarily through incorporation into nascent DNA strands introducing a terminal propargyl group that serves as a reactive alkyne handle for conjugation reactions via click chemistry approaches Based on these pharmacological properties 7-Deaza-7-Propargylamino-dATP holds research potential in DNA labeling fluorescent probe generation and studies of DNA polymerase activity specificity and DNA damage detection and repair mechanisms in molecular biology and biomedical research
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Digoxigenin-11-dUTP is a modified nucleotide analog designed for incorporation into DNA or cDNA by enzymatic processes substituting for natural dTTP The digoxigenin moiety attached via an 11-atom linker to the C5-position of the uridine base facilitates recognition by anti-digoxigenin antibodies labeled with horseradish peroxidase alkaline phosphatase or fluorophores Digoxigenin-11-dUTP is enzymatically incorporated using methods such as PCR amplification nick translation primer extension 3 -end labeling and reverse transcription Based on these properties Digoxigenin-11-dUTP is primarily utilized in probe-based assays sequencing and fluorescent or chromogenic in situ hybridization (ISH) applications
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FITC-labeled ODN 2395 (sodium) is a C class oligodeoxynucleotide that acts as a TLR9 agonist. It is intended for research use only and should not be sold to patients. This product is ideal for evaluating CpG ODN cellular uptake and localization studies.
Can be used to evaluate CpG ODN cellular uptake and localization
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5-Propargylamino-dCTP is a modified nucleoside triphosphate analog featuring a cytosine base with a propargylamino substituent introducing an alkyne functional group 5-Propargylamino-dCTP is incorporated into DNA strands mediated by DNA polymerases during active DNA synthesis This modification enables covalent conjugation to azide-bearing probes via copper-catalyzed azide-alkyne cycloaddition (CuAAC) Based on these pharmacological properties 5-Propargylamino-dCTP holds research potential in the detection and analysis of cellular proliferation DNA replication dynamics nucleic acid repair subcellular localization studies fluorescence labeling and molecular imaging-based nucleic acid research methodologies
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Thymidine 5′-monophosphate p-nitrophenyl ester sodium is a synthetic nucleotide derivative supplied as the sodium salt for research use. It functions as a chromogenic substrate for enzymatic and analytical assays, facilitating colorimetric detection of phosphatase and nucleotidase activity. Supplied as a solid with high purity for laboratory applications.
High purity suitable for analytical and biochemical assays.
Sodium salt form provided as a solid for ease of handling and storage.
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GTP-Binding Protein Fragment G alpha is a peptide fragment derived from the amino-terminal region of the alpha subunit of GTP-binding proteins It is designed to aid in elucidating the mechanisms of membrane association and -subunit interactions in cell signaling pathways GTP-Binding Protein Fragment G alpha exerts its biological activity by retaining membrane-binding properties independent of the nucleotide-binding state anchoring the protein to the cytoplasmic membrane surface This peptide fragment serves as an experimental tool to study membrane-association mechanisms and signal transduction pathways in biochemical and biomedical research Based on these properties GTP-Binding Protein Fragment G alpha holds research potential in investigating the molecular basis of G protein-mediated signal transduction and protein-membrane interactions
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4-Thio-UTP is a nucleotide triphosphate analog in which the oxygen atom at the 4-position of uracil is substituted by a sulfur atom It can be incorporated into RNA molecules during in vitro transcription reactions producing RNAs containing 4-thiouridine modifications This modification provides unique advantages in studying protein interactions RNA modifications and RNA labeling Due to the presence of the sulfur atom RNA modified with 4-Thio-UTP can form cross-links with proteins upon ultraviolet (UV) irradiation facilitating the study of RNA-protein interactions Additionally 4-Thio-UTP can be employed in research on RNA folding and function as well as in studying the cellular localization and roles of RNA
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