Bioactive Small Molecules
Cayman Chemical ANTIBODY SBP-7455 5mg
A dual inhibitor of ULK1 and ULK2 (IC50s = 13 and 476 nM, respectively, for the recombinant human enzymes in cell-free assays); inhibits increases in autophagic flux and induces apoptosis in serum-deprived MDA-MB-468 breast cancer cells at 10 µM; reduces the viability of MDA-MB-468 cells at 0.19 µM alone or in combination with olaparib
Selleck Chemical LLC ASP4132 S8953-25MG
ASP4132 is a potent and orally active activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) with EC50 of 0 018 M ASP4132 is used as a clinical candidate for the treatment of human cancer
Medchemexpress LLC Hexamethylphosphoramide | 680-31-9 | MFCD00008303 | 99.9% | 179.20 g/mol | C6H18N3OP | 100g
Hexamethylphosphoramide is an orally active polar aprotic solvent flame retardant additive and carcinogen Hexamethylphosphoramide undergoes cytochrome P-450-mediated N-demethylation to Formaldehyde Hexamethylphosphoramide induces DNA-protein crosslinks Hexamethylphosphoramide has been linked to nasal tumors (squamous cell carcinoma adenoid squamous cell carcinoma) squamous metaplasia rhinitis tracheitis and reversible and irreversible infertility[1][2][3][4][5][6][7]
Medchemexpress LLC Pexopiprant | 932708-14-0 | 99.4% | 456.27 | 200 MG
Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2), with a Ki < 100 nM. It is for research use only and not sold to patients.
- Used in studies of asthma.
- Oral antagonist of the prostaglandin D2 receptor 2 (DP2).
- Ki of less than 100 nM.
- For research use only.
Medchemexpress LLC Poseltinib | 1353552-97-2 | 98.1% | 470.52 | 1 ML
Poseltinib is an orally active, selective, irreversible small molecule Bruton tyrosine kinase (BTK) inhibitor with an IC50 of 1.95 nM. It effectively inhibits signaling mediated by B cell receptors (BCR), Fc receptors (FcR), and Toll-like receptors (TLR). Poseltinib also exhibits anti-inflammatory activity and is being researched for rheumatoid arthritis.
- Orally active, selective, irreversible small molecule Bruton tyrosine kinase (BTK) inhibitor.
- Effectively inhibits signaling mediated by B cell receptors (BCR), Fc receptors (FcR), and Toll-like receptors (TLR).
- Exhibits anti-inflammatory activity.
- Potential for research in rheumatoid arthritis.
- Appearance: solid, light yellow to yellow.
Cayman Chemical ANTIBODY TFAP 25mg
An inhibitor of COX-1 (IC50 = 0.8 μM); selective for COX-1 over COX-2 (IC50 = 210 μM); reduces acetic acid-induced writhing in mice at 10 and 30 mg/kg; has analgesic activity in the formalin test in rats at 30 mg/kg; does not induce gastric damage in rats at doses up to 300 mg/kg
Selleck Chemical LLC Pine Nodular Branch Extract E3669-5MG
Pine Nodular Branch Extract is extracted from the branch of Pinus Linn
Selleck Chemical LLC Balsam PearExtract E3392-5MG
Balsam Pear Extract is extracted from Momordica charantia which is used in the treatment of diabetes mellitus
Selleck Chemical LLC Deoxypodophyllotoxin E2017-1MG
Deoxypodophyllotoxin (DPT) a derivative of podophyllotoxin is a lignin from Anthriscus sylvestris with potent antimitotic anti-inflammatory and antiviral activities
Selleck Chemical LLC Daunorubicin E8164-5MG
Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity Daunorubicin inhibits DNA and RNA synthesis Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis Daunorubicin is also an anthracycline antibiotic Daunorubicin can be used in the research of infection and variety of cancers including leukemia non-Hodgkin lymphomas Ewing s sarcoma Wilms tumor
Cayman Chemical ANTIBODY AMG-TIe2-1 10mg
An inhibitor of Tie2 and VEGFR2 (IC50s = 1 and 3 nM, respectively, in a HTRF assay); inhibits angiopoietin 1-induced Tie2 autophosphorylation in EA.hy926 human endothelial cells (IC50 = 10 nM).
Selleck Chemical LLC Bamboo Sap Extract E3886-5MG
Bamboo Sap Extract is extracted from bamboo sap which is used for the wellness of your skin hair and nails
Apexbio Technology LLC SAR407899 923359-38-0 10mg
SAR407899 (CAS 923359-38-0) is an ATP-competitive inhibitor that selectively targets the ROCK-2 isoform of Rho-associated protein kinases It demonstrates an IC50 of 135 nM for ROCK-2 and binds with Ki values of 36 nM and 41 nM for human and rat ROCK-2 respectively Through selective modulation of the ROCK signaling pathway SAR407899 has been shown to sustain inhibition of migration complex formation in cellular models This compound is thus suited for investigating cell migration cytoskeletal reorganization and the functional role of ROCK signaling in biomedical research
Apexbio Technology LLC Vatalanib (PTK787) 2HCl 212141-51-0 100mg
Vatalanib (PTK787) 2HCl (CAS 212141-51-0) is a small molecule inhibitor targeting vascular endothelial growth factor (VEGF) receptor tyrosine kinases including VEGFR/KDR (IC50 0 037 M) VEGFR/Flt-1 (IC50 0 077 M) and VEGFR/Flk (IC50 0 27 M) It also inhibits other receptor tyrosine kinases such as PDGFR- (IC50 0 58 M) c-Kit (IC50 0 73 M) and c-Fms (IC50 1 4 M) Through blockade of these pathways Vatalanib suppresses VEGF-mediated signaling and angiogenesis It is utilized in research investigating mechanisms of angiogenesis and has potential applications in studies of solid tumors and other angiogenesis-dependent diseases