Bioactive Small Molecules
Cayman Chemical CInamyl3 4dIhydroxyaCyn 5mg
A 5-LO inhibitor (IC50 = 15 nM); selective for 5-LO over 12-LO and 15-LO (IC50s = 500 and 300 nM, respectively); inhibits A23187-induced 5-LO product formation in isolated human PMNs, monocytes, and whole blood (IC50s = 0.5, 0.45, and 1.5 µM, respectively); increases survival in a mouse model of PAF-induced lethal shock at 3.5 mg/kg; reduces pleural levels of LTB4 in a rat model of carrageenan-induced pleurisy
Cayman Chemical ANTIBODY AZ 32 1mg
An ATM kinase inhibitor (IC50 = 50s = 4.6 and >4.6 µM, respectively); enhances radiation-induced cytotoxicity in a panel of five human glioma cells expressing wild-type or mutant p53; increases survival in a U87-281G glioma orthotopic mouse xenograft model, as well as a NCI H2228 NSCLC mouse xenograft model of metastatic brain tumors, at 200 and 50 mg/kg, respectively, in combination with ionizing radiation
Medchemexpress LLC EGF Rat Tag Free 50ug
Recombinant rat epidermal growth factor (EGF) supplied as a tag-free, 0.2 μm-filtered solution in PBS for research use. EGF promotes epithelial proliferation, migration, and wound closure; the product is expressed in E. coli, includes the provided amino-acid sequence, and is manufactured with low endotoxin suitable for cell-based assays.
- Supplied as a tag-free, 0.2 μm-filtered solution in PBS.
- Promotes epithelial proliferation and migration.
- Accelerates epithelial wound closure.
- Expressed in E. coli with provided amino-acid sequence.
- Low endotoxin: <1 EU/μg (LAL method).
- Approximate molecular weight 6-9 kDa by SDS-PAGE.
- Store at -80°C; avoid repeated freeze-thaw cycles.
- For research use only; not validated for clinical applications.
![Medchemexpress LLC (S)-2-amino-3-(benzo[b]thiophen-3-yl)propanoic acid | 72120-71-9 | MFCD00079684 | 221.28 g·mol⁻¹ | C11H11NO2S | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000299611.png-250.jpg)
Medchemexpress LLC (S)-2-amino-3-(benzo[b]thiophen-3-yl)propanoic acid | 72120-71-9 | MFCD00079684 | 221.28 g·mol⁻¹ | C11H11NO2S | 100 MG
(S)-2-Amino-3-(benzo[b]thiophen-3-yl)propanoic acid is the S-enantiomer of a benzo[b]thiophene-substituted alanine. It is a chiral, heteroaryl-containing amino acid used as a building block in medicinal chemistry, peptide synthesis, and biochemical research. Supplied as a solid for research use only.
- Chiral S-enantiomer for stereospecific studies.
- Benzo[b]thiophene side chain provides heteroaryl functionality.
- Suitable as a building block in peptide synthesis and small-molecule design.
- Solid form; molecular formula C11H11NO2S; molecular weight 221.28 g·mol⁻¹.
- Intended for research use only.
Medchemexpress LLC 5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-benzopyrano[4,3-c]triazolo[1,2-a]pyridazine-1,3 | 908568-01-4 | 99.8%
5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-benzopyrano[4,3-c]triazolo[1,2-a]pyridazine-1,3 | 908568-01-4 | 99.8%
Cayman Chemical ANTIBODY TAS 116 5mg
An Hsp90 inhibitor; selectively binds to Hsp90α and Hsp90β (Kis = 34.7 and 21.3 nM, respectively) over GRP94 and TRAP1 (Kis = 50,000 nM for both); reduces intratumor protein levels of HER2, HER3, and Akt and reduces tumor growth in a HER2-expressing NCI N87 mouse xenograft model at 3.6, 7.1, and 14 mg/kg; does not induce photoreceptor injury in rats at 12 mg/kg per day
Cayman Chemical DIhydrocnabIelsoIn 5mg
An analytical reference standard that is structurally similar to known phytocannabinoids; intended for research and forensic applications
AdipoGen 3,4-Dimethoxychalcone (10 mg)
Chemical. CAS: 5416-71-7. Formula: C17H16O3. MW: 268.3. Synthetic. Caloric restriction mimetic (CRM). Caloric restriction mimetics (CRMs) are natural or synthetic compounds that mimic the health-promoting and longevity-extending effects of caloric restriction. CRMs provoke the deacetylation of cellular proteins coupled to an increase in autophagic flux in the absence of toxicity. Induces the deacetylation of cytoplasmic proteins and stimulates autophagic flux, requiring transcription factor EB (TFEB)- and E3 (TFE3)-dependent gene transcription and mRNA translation to trigger autophagy. Stimulates the translocation of TFEB and TFE3 into nuclei both in vitro and in vivo, in hepatocytes and cardiomyocytes. Consequently induces autophagy in vitro and in vivo, mediates autophagy-dependent cardioprotective effects and improves the efficacy of anticancer chemotherapy in vivo.
Medchemexpress LLC Copanlisib | 1032568-63-0 | 480.52 | 100 MG
Copanlisib is a potent, selective, and ATP-competitive pan-class I PI3K inhibitor. It demonstrates over 2,000-fold selectivity against other lipid and protein kinases, with the exception of mTOR, and exhibits superior antitumor activity, making it suitable for cancer research.
- Potent, selective, and ATP-competitive pan-class I PI3K inhibitor
- Has IC₅₀s of 0.5 nM for PI3Kα, 0.7 nM for PI3Kδ, 3.7 nM for PI3Kβ, and 6.4 nM for PI3Kγ
- Exhibits over 2,000-fold selectivity against other lipid and protein kinases (excluding mTOR)
- Demonstrates superior antitumor activity
- Induces apoptosis in a subset of tumor cell lines
- Completely inhibits PI3K-mediated AKT phosphorylation
- Potently inhibits cell proliferation in various human tumor cell lines
Cayman Chemical ANTIBODY CBGH 1mg
An analytical reference standard categorized as a hexyl-chain homolog of CBG; intended for research and forensic applications
Medchemexpress LLC Amino-PEG16-acid | 2922656-52-6 | MFCD26793767 | 95.0% | 793.93 | C35H71NO18 | 5 MG
Amino-PEG16-acid is a polyethylene glycol (PEG)-based linker bearing a terminal amine and carboxylic acid. It provides a flexible, water-soluble spacer for PROTAC synthesis and bioconjugation, supplied as a solid with reported purity of 95.0% and molecular weight of 793.93 g/mol. Analytical documents and handling instructions (SDS, COA, HNMR, MS) are available from the manufacturer.
- Provides a flexible, hydrophilic spacer for linking ligands.
- Contains reactive amine and carboxylic acid functional groups for conjugation.
- Suitable for PROTAC synthesis and other bioconjugation workflows.
- Supplied as a solid with reported purity of 95.0%.
- Soluble in common polar solvents such as DMSO, DMF, and methanol.
- Powder stable at -20°C for long-term storage; specific in-solution stability limited to refrigerated/ultra-low temperatures.
Aobious Inc AOBIOUS USP7 Inhibitor, Non-covalent, Selective, 98% HPLC
FT671 is a potent, non-covalent, and selective inhibitor of Ubiquitin-Specific Protease 7 (USP7), a deubiquitinating enzyme involved in regulating various cellular processes, including protein stability and signaling pathways.
- Potent, non-covalent, and selective inhibitor of USP7.
- Binds to the catalytic domain of USP7, inhibiting its deubiquitinating activity.
- IC50 of approximately 52 nM; dissociation constant (Kd) of 65 nM.
- Stabilizes p53 by inhibiting USP7, leading to increased p53 levels.
- Induces G1 phase arrest and apoptosis in various cancer cell lines.
- Effective in preclinical models for cancer research, delaying tumor growth.
Cayman Chemical ANTIBODY HUP-55 5mg
A prolyl endopeptidase inhibitor (IC50 = 5 nM); reduces α-synuclein dimerization in Neuro2a cells, induces autophagy in HEK293 cells, and decreases hydrogen peroxide-induced increases in ROS production in SH-SY5Y cells at 10 µM; decreases ipsilateral paw use and striatal oligomeric α-synuclein levels in an AAV-αSyn mouse model of Parkinson’s disease at 10 mg/kg