Bioactive Small Molecules
Medchemexpress LLC Simufilam (PTI-125) | 1224591-33-6 | 99.8% | 259.35 | 1 ML
Simufilam (PTI-125) is an orally active FLNA modulator. It restores NMDAR signaling and Arc expression, inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, and reduces Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. This modulator can be used for research of Alzheimer's disease.
- Restores NMDAR signaling and Arc expression
- Inhibits overactive mTOR signaling
- Improves insulin sensitivity
- Reduces Aβ42-induced neuroinflammation
- Reduces tau protein hyperphosphorylation
Medchemexpress LLC 5'-O-TBDMS-Bz-dA | 51549-39-4 | 98.37% | 469.61 | 1 ML
5'-O-TBDMS-Bz-dA is a nucleoside that acts as a protective and modification agent. This white to off-white solid is for research purposes only, not for human use.
- Protective and modification effects
- Used in DNA/RNA synthesis research
- Classified as a nucleoside analog and adenosine derivative
- Related to cancer, blood, and cardio-cerebrovascular disease research
- Soluble in DMSO: 100 mg/mL
- Formulatable for in vivo experiments
eMolecules 41797-88-0 | ChemScene | 233-Trimethyl-3H-indol-5-ol | 100mg | 768994307 | CS-0617004 | 175.231 | C11H13NO
Medchem Express | Osilodrostat | 2mg | 446267317 | HY-16276 | 928134-65-0 | MFCD25976825 | 227.242 | C13H10FN3
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Cayman Chemical CVT-12012, Purity: ≥98%, CAS: 1018675-35-8, 25 mg
An SCD inhibitor (IC50 = 6.1 nM in HepG2 cells); dose-dependently reduces levels of palmitoleic acid and vaccenic acid in the plasma and liver of rats fed a high-sucrose diet; reduces hepatic triglyceride levels in sucrose-fed rats at 20 mg/kg
Medchemexpress LLC Cxcr2 antagonist 8 | 182498-30-2 | 98.38% | 303.27 | 5 MG
CXCR2 antagonist 8 is a potent and selective CXCR2 antagonist. It can be used for insulin resistance research.
- Potent and selective CXCR2 antagonist
- Used for insulin resistance research
Medchemexpress LLC Atg7-IN-2 | 2226227-75-2 | 99.3% | 376.35 | 50 MG
ATG7-IN-2 (compound 1) is a potent ATG7 inhibitor, with an IC50 of 0.089 μM. It inhibits the autophagy marker LC3B. This product is for research use only and is not sold to patients.
- Potent ATG7 inhibitor with an IC50 of 0.089 μM.
- Inhibits autophagy marker LC3B.
- Inhibits the formation of the ATG7-ATG8 thioester in HEK293 cells with an IC50 of 0.335 μM.
- Suppresses LC3B lipidation in H4 cells with an IC50 of 2.6 μM.
- Reduces cell viability in H1650 cells with an EC50 of 2.6 μM.
Cayman Chemical 3,4-trimethylene-α-Piperidinovalerophenone (hydrochloride), Purity: ≥98%, 5 mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Medchemexpress LLC Stearoyl glutamic acid sodium | 38517-23-6 | C23H42NNaO5 | 500 MG
Stearoyl glutamic acid sodium, also known as Sodium stearoyl glutamate, is an anionic emulsifier suitable for cosmetic applications. It also functions as an anionic surfactant and an amino acid alkyl amide sensitizer, which may potentially lead to allergic contact dermatitis.
- Anionic emulsifier for cosmetics.
- Functions as an anionic surfactant.
- An amino acid alkyl amide sensitizer.
Cayman Chemical Rosavin, Purity: ≥98%, CAS: 84954-92-7, 5 mg
A diglycoside with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 5.86 µg/ml); inhibits the proliferation of NCI H69, NCI H526, and NCI H446 SCLC cells at 5-100 µM; inhibits concanavalin A- or anti-CD3 and anti-CD28 antibody-induced growth of Jurkat T cells (IC50s = 80 and 74 µM, respectively) and reduces TRAIL levels in isolated mouse splenic T cells at 0.5, 5, and 50 µM; reduces ferroptosis-related mitochondrial changes and increased levels of 4-HNE and MDA in type II alveolar epithelial cells, as well as reduces lung tissue iron levels, in a rat model of intratracheal PM2.5-induced lung injury at 100 µM
Medchemexpress LLC GPR84 antagonist 2 | 2244269-74-5 | 99.06% | C28H16Cl2NaO4PS2 | 1 ML
GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). It demonstrates improved potency in calcium mobilization assays and inhibits neutrophil and macrophage chemotaxis upon GPR84 activation, showing potential for ulcerative colitis research.
- Potent and selective GPR84 antagonist
- Orally active with an IC50 of 8.95 nM
- Improves potency in calcium mobilization assays
- Inhibits neutrophil and macrophage chemotaxis
- Potential for ulcerative colitis research
- Solid storage: -20°C, sealed, away from moisture
- In solvent storage: -80°C for 6 months; -20°C for 1 month, sealed, away from moisture
Medchemexpress LLC N-methyltyramine hydrochloride | 13062-76-5 | MFCD01707290 | 99.4% | 187.67 g/mol | C9H14ClNO | 5 G
N-methyltyramine hydrochloride is the hydrochloride salt of N-methyltyramine, a naturally occurring phenethylamine isolated from Citrus species. Supplied as a white to off-white solid for research use, it is employed as a biochemical and pharmacological reference compound, including studies of adrenergic activity.
- High purity (99.4%).
- Molecular formula C9H14ClNO; molecular weight 187.67 g/mol.
- CAS number 13062-76-5 for precise identification.
- White to off-white solid suitable for analytical applications.
- Available in small lab pack sizes, including 5 G.
- Store sealed, away from moisture; short-term storage in solution at -20°C to -80°C.
Cayman Chemical GSK547, Purity: ≥98%, CAS: 2226735-55-1, 1 mg
A RIPK1 inhibitor (IC50 = 31 nM); selective for RIPK1 over a panel of 371 kinases at 10 µM; increases survival and reduces tumor volume and the number of liver metastases in a P48Cre KrasG12D orthotopic mouse model of progressive PDA at 100 mg/kg; adoptive transfer of tumor-infiltrating T cells isolated from GSK547-treated mice protects against orthotopic PDA tumor growth in mice; reduces plasma levels of TNF-α and IL-1β and decreases macrophage infiltration in aortic sinus lesions in an ApoESA/SA mouse model of early-phase atherogenesis
Cayman Chemical Pirarubicin, Purity: ≥95%, CAS: 72496-41-4, 5 mg
An anthracycline with anticancer activity; interacts with topoisomerase II; inhibits the growth of human HeLa and C33A cervical, as well as T-24 bladder cancer cells (IC50s = 29, 52, and 36 ng/ml, respectively); inhibits the growth of human Huh7 and MHCC97H liver cancer cells (IC50s = 0.159 and 0.374 μM, respectively); inhibits the growth of mouse M5076 ovarian cancer cells in vitro (IC50 = 0.366 μM) and in vivo in a mouse allograft model at 2 mg/kg for four days
Medchemexpress LLC HY-103583 5mg Medchemexpress, KDU731 CAS:1610610-48-4 Purity:>98%
Medchemexpress, HY-103583 5mg KDU731 CAS:1610610-48-4 KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo. KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical TAK-385, Purity: ≥98%, CAS: 737789-87-6, 1 mg
A GnRHR antagonist (IC50s = 0.33 and 0.32 nM for the human and monkey receptors, respectively); selective for these receptors over the rat GnRHR receptor (IC50 = 9,800 nM), as well as a panel of 134 enzymes and receptors at 10 µM; 95-fold more potent at inhibiting GnRH-induced arachidonic acid release in CHO cells expressing human GnRHR compared with those expressing monkey GnRHR; decreases testis, ventral prostate, ovary, and uterus weight in human GNRHR knock-in mice at 3-200 mg/kg per day for 28 days; decreases plasma luteinizing hormone levels in castrated cynomolgus monkeys at 1 and 3 mg/kg