Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,431 – 5,445 of 60,541 results

5,431

Medchemexpress LLC Antiviral agent 5 | 2698336-82-0 | 98.9% | 386.44 | 100 MG

Antiviral agent 5 is an intermediate used in antiviral agents targeting 3C and 3CL proteases, including SARS-CoV-2 Mpro. It is for research use only and not sold to patients.

Used in antiviral agents targeting 3C and 3CL proteases.
Targets SARS-CoV-2 Mpro.
For research use only.
Purity of 98.93%.
Molecular weight: 386.44.
Appears as an oil, colorless to light yellow.
Soluble in DMSO at 100 mg/mL.

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5,432

eMolecules 19186-35-7 | Medchem Express | Deoxypodophyllotoxin | 5mg | 523883510 | HY-N2500 | MFCD01699018 | 398.411 | C22H22O7

Ambeed | 5-Iodopicolinic acid | 250mg | 552628870 | A186931 | 32046-43-8 | MFCD09910324 | 249.007 | C6H4INO2

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5,433

Cayman Chemical TM5441, Purity: ≥98%, CAS: 1190221-43-2, 1 mg

A PAI-1 inhibitor; decreases survival of HT1080, HCT116, Daoy, MDA-MB-231, and Jurkat cancer cells (IC50s = 13.9-51.1 µM); inhibits branching of HUVECs (50 µM); disrupts tumor vasculature in mouse xenograft models (20 mg/kg per day); prevents L-NAME-induced hypertension and cardiac hypertrophy; protects against NAFLD in mice induced by high-fat diet

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5,434

Medchemexpress LLC RMC-5552 5MG

RMC-5552 is a potent and selective mTORC1 inhibitor. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC50s of 0.14 nM and 0.48 nM, respectively. RMC-5552 shows much lower pAKT inhibition (IC50 of 19 nM), resulting in mTORC1/mTORC2 selectivity approaching 40-fold. RMC-5552 has anti-cancer activity.

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5,435

Medchemexpress LLC Oxadiazon | 19666-30-9 | 98.5% | 500 MG

Oxadiazon | 19666-30-9 | 98.5% | 500 MG

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5,436

Medchemexpress LLC BAY-179 | 2764880-87-5 | 99.83% | C23H21N5OS | 50 MG

BAY-179 is a chemical probe that acts as a potent, selective, and species cross-reactive complex I inhibitor. It exhibits IC50 values of 79 nM, 38 nM, 27 nM, and 47 nM for human, mouse, rat, and dog complex I, respectively. It also demonstrates moderate to good in vitro metabolic stability (Fmax of 81%).

Potent and selective complex I inhibitor
Species cross-reactive (human, mouse, rat, dog)
Moderate to good in vitro metabolic stability (Fmax of 81%)

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5,437

TARGETMOL CHEMICALS INC P53R3 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants including p53 R175H p53 R248W and p53 R273H . P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53 M237I to several target gene promoters. P53R3 strongly enhances the mRNA total protein and cell surface expression of the death receptor death receptor 5 (DR5) . P53R3 is used for cancer research. purity: 97%

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5,438

Cayman Chemical N-desmethyl Azelastine, Purity: ≥98%, CAS: 47491-38-3, 5 mg

An active metabolite of azelastine; inhibits acetylcholine-induced depolarization and contractions in isolated human tracheal smooth muscle at 1 µM; inhibits transport of daunorubicin and digoxin in LLC-GA5-CoL150 cells overexpressing P-gp (IC50s = 11.8 and 41.8 µM, respectively)

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5,439

Cayman Chemical Arjunolic Acid, Purity: ≥98%, CAS: 465-00-9, 5 mg

A triterpene; scavenges DPPH radicals in a cell-free assay at 0.8 mM; prevents arsenic-induced decreases in the activity of SOD1, catalase, GST, and glutathione reductase in mouse brain at 20 mg/kg for four days; reduces tumor growth in an Ehrlich murine spontaneous adenocarcinoma model at 100 and 250 mg/kg for 20 days; reduces cisplatin-induced renal fibrosis and increased kidney TNF-α and IL-1β levels in mice at 100 and 250 mg/kg per day for 10 days

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5,440

Cayman Chemical 3-(3-Hydroxyphenyl)-3-hydroxypropanoic Acid, Purity: ≥98%, CAS: 3247-75-4, 5 mg

A urinary metabolite

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5,441

Medchemexpress LLC HY-N8441 5mg Medchemexpress, Neriifolin CAS:466-07-9 Purity:>98%

Medchemexpress, HY-N8441 5mg Neriifolin CAS:466-07-9 Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[2. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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5,442

TARGETMOL CHEMICALS INC TUBULOSIDE B 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. The neuroprotective effect of tubuloside B one of the phenylethanoids isolated from the stems of Cistanche salsa on tumor necrosis factor-alpha (TNFalpha)-induced apoptosis in SH-SY5Y neuronal cells. purity: 99%

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5,443

Medchemexpress LLC hVEGF-IN-1 | 1637443-98-1 | 99.3% | 581.75 g/mol | C34H43N7O2 | 100 MG

hVEGF-IN-1 is a quinazoline-derived small-molecule research reagent that inhibits VEGF-A expression by binding G-rich sequences within the IRES-A element and destabilizing G-quadruplex structures. It has been reported to reduce VEGF-A protein levels, hinder tumor cell migration, and suppress tumor growth in cellular assays.

Binds G-rich IRES-A sequence and destabilizes G-quadruplex structures.
Reduces VEGF-A protein expression in cellular assays.
Inhibits tumor cell migration and growth in vitro.
High chemical purity suitable for research applications.
Available in multiple solid and solution package sizes for experimental flexibility.

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5,444

Cayman Chemical Glutaurine, Purity: ≥90%, CAS: 56488-60-9, 250 mg

A dipeptide; enhances potassium-induced release of L-glutamate and inhibits kainate-induced formation of cGMP in isolated mouse cerebral cortical slices at 0.1 and 1 mM, respectively; decreases plasma levels of T3 and increases plasma TSH levels in rats at 600 µg/kg; prevents electroconvulsive shock-induced amnesia in rats at 50 µg/animal, p.o.

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5,445

Cayman Chemical BCI-121, Purity: ≥98%, CAS: 432529-82-3, 50 mg

An inhibitor of SMYD3; inhibits H3K4 di- and trimethylation in HT-29 cell lysates at 100 µM; inhibits proliferation in a panel of colorectal, lung, pancreatic, prostate, and ovarian cancer cell lines in an SMYD3 expression-dependent manner; induces cell cycle arrest at the S phase and decreases global H5K4 methylation and H3K4 dimethylation in HT-29 cells; intratumoral injection reduces tumor volume in an MHCC97H HCC mouse xenograft model at 20 µM

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Medchemexpress LLC Antiviral agent 5 | 2698336-82-0 | 98.9% | 386.44 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC RMC-5552 5MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Oxadiazon | 19666-30-9 | 98.5% | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC BAY-179 | 2764880-87-5 | 99.83% | C23H21N5OS | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-N8441 5mg Medchemexpress, Neriifolin CAS:466-07-9 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC hVEGF-IN-1 | 1637443-98-1 | 99.3% | 581.75 g/mol | C34H43N7O2 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More