Bioactive Small Molecules
Cayman Chemical L-655,708, Purity: ≥98%, CAS: 130477-52-0, 5 mg
A ligand for α5 subunit-containing GABAA receptors that has nootropic activity; selectively binds to α5 subunit-containing GABAA receptors over α1, α2, or α3 subunit-containing receptors (Kis = 1, 70, 48, and 31 nM, respectively, for recombinant human receptors); increases the amplituted of EPSPs in mouse hippocampal slices at 10 nM; decreases the latency to find the platform and increases time spent in the target quadrant in the Morris water maze in mice
TARGETMOL CHEMICALS INC PREXASERTIB 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. purity: 97%
Cayman Chemical Quinaprilat, Purity: ≥90%, CAS: 82768-85-2, 5 mg
An ACE inhibitor (IC50 = 0.06 nM) and active metabolite of quinapril; inhibits LPC-induced calcium overload and rod to round cell shape change in isolated rat cardiomyocytes at 20 and 50 µM; reduces the frequency of ventricular fibrillation in a dog model of myocardial ischemia and reperfusion injury at 3 µg/kg; reduces blood pressure and proteinuria in rat models of uranyl nitrate- or 5/6 nephrectomy-induced chronic renal failure at 0.1 mg/kg
Medchemexpress LLC Secoxyloganin | 58822-47-2 | MFCD20260822 | 99.3% | 404.37 g/mol | C17H24O11 | 10 MG
Secoxyloganin is an iridoid glycoside isolated from Lonicera japonica and provided for research and analytical use. It is studied for allergy-preventive activity and its effects on blood flow. The compound is a white to light-yellow solid with a molecular weight of 404.37 g/mol and high purity suitable for analytical applications.
- High purity: 99.3% suitable for analytical use.
- Available in multiple pack sizes, including 10 MG.
- Solvent stability: store in solvent at -80°C for long-term, -20°C for short-term.
- Appearance: white to light yellow solid.
- Intended for research and analytical applications only (not for human use).
Cayman Chemical SNX-2112, Purity: ≥98%, CAS: 908112-43-6, 10 mg
A potent Hsp90 inhibitor (Kd = 30 nM); induces down-regulation of client proteins HER2 and Akt in vitro; inhibits proliferation in a panel of cancer cell lines (IC50s = 10-50 nM); inhibits tumor growth in a BT474 breast cancer mouse xenograft model; active metabolite of the prodrug SNX-5542 and preferentially accumulates in tumor tissue of mice treated with a single oral dose of 75 mg/kg SNX-5542
Cayman Chemical HS-024 (trifluoroacetate salt), Purity: ≥98%, 5 mg
An MC4R antagonist (Ki = 0.29 nM); selective for MC4R over MC1R, MC3R, and MC5R (Kis = 18.6, 5.45, and 3.29 nM, respectively); inhibits cAMP accumulation induced by α-MSH in COS-1 cells expressing MC1R, MC3R, MC4R, or MC5R at 100 nM; increases food intake in rats at 0.3, 1, or 3 nmol/animal; intrathecal administration inhibits mechanical allodynia at 30 minutes post-injection in a rat model of spinal nerve ligation-induced neuropathic pain at 1.5 nmol/animal; reduces stress-induced reinstatement of nicotine seeking in the foot shock test in rats
TARGETMOL CHEMICALS INC REZATOMIDINE 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Rezatomidine (AGN203818) is a selective antagonist of (alpha)2-adrenergic receptor and can be used in studies about chronic pain including neuropathic pain. purity: 99%
Medchemexpress LLC HY-50878 50mg , Crizotinib CAS:877399-52-5 Purity:>98%
HY-50878 50mg Crizotinib CAS: 877399-52-5 Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical SC-43, Purity: ≥98%, CAS: 1400989-25-4, 1 mg
An SHP-1 activator; activates SHP-1 phosphatase activity in a cell-free assay and inhibits IL-6-induced phosphorylation of STAT3 in PLC/PRF/5 cells at 10 µM; inhibits the proliferation of PLC/PRF/5 cells (IC50 = 0.5 µM); decreases disease severity and improves survival in a mouse model of carbon tetrachloride-induced liver fibrosis at 10 and 20 mg/kg
Medchemexpress LLC 4-vinylcyclohexene dioxide | 106-87-6 | MFCD00022354 | 98.0% | 140.18 g/mol | C8H12O2 | 1 G
4-Vinylcyclohexene dioxide is a diepoxide research reagent used to study reproductive toxicity and premature ovarian insufficiency. It is a colorless to light yellow liquid with molecular formula C8H12O2, molecular weight 140.18 g/mol, and reported purity 98.0% (NMR). Handle and store per supplier recommendations; material is for research use only and may be restricted in some territories.
- Used to model ovarian follicle toxicity and reproductive toxicity
- Colorless to light yellow liquid suitable for laboratory use
- Purity 98.0% (NMR) as reported by certificate of analysis
- Molecular weight 140.18 g/mol; formula C8H12O2
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months)
- For research use only; not for human or clinical use
Medchemexpress LLC Satigrel 25mg | 111753-73-2 | 337.37 g/mol | C20H19NO4 | 25 MG
Satigrel is a research-grade small molecule inhibitor of prostaglandin-endoperoxide synthase 1 (PGHS1/COX-1) that reduces thromboxane A2 synthesis and inhibits platelet aggregation. Intended for preclinical biochemical and pharmacological research only; not for human or veterinary use.
- Selective PGHS1 (COX-1) inhibitor (IC50: 0.081 μM).
- Also shows activity against PGHS2 (IC50: 5.9 μM) and some phosphodiesterase isoforms.
- Molecular formula C20H19NO4; molecular weight ≈337.37 g/mol.
- High purity (99.85%) suitable for biochemical assays.
- Available in small milligram pack sizes for laboratory research.
- CAS number 111753-73-2 for unambiguous identification.
Medchemexpress LLC Narcissin (narcissoside) | 604-80-8 | MFCD00017734 | 99.8% | 624.54 | C28H32O16 | 10 MG
Narcissin (narcissoside) is a flavonol glycoside research reagent with antioxidant activity. It scavenges peroxynitrite and is used in studies of oxidative stress and inflammatory signaling. The compound is a high-purity solid with molecular weight 624.54 g/mol and is supplied in small research quantities.
- High purity: 99.82%.
- Scavenges peroxynitrite (ONOO-) with IC50 = 3.5 μM (authentic) and 9.6 μM (SIN-1-derived).
- Suitable for oxidative stress and inflammatory signaling assays.
- Supplied as a solid for laboratory research applications.
- Store protected from light; recommended storage 4°C; in solvent: -80°C (6 months), -20°C (1 month).
![eMolecules 2009273-67-8 | GNE-6640 | Medchem Express | 330.391 | C20H18N4O | 98 | CCc1c(cnc(N)c1-c1ccc(O)cc1)-c1ccc2[nH]ncc2c1 | 10mg | 441681907](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1732546.jpg-250.jpg)
eMolecules 2009273-67-8 | GNE-6640 | Medchem Express | 330.391 | C20H18N4O | 98 | CCc1c(cnc(N)c1-c1ccc(O)cc1)-c1ccc2[nH]ncc2c1 | 10mg | 441681907
Ambeed | Methyl 4-methoxy-2-methylbenzoate | 1g | 552712499 | A344306 | 35598-05-1 | MFCD06203918 | 180.203 | C10H12O3
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Medchemexpress LLC HY-135831 5mg Medchemexpress, AHR antagonist 2 CAS:2338747-54-7 Purity:>98%
Medchemexpress, HY-135831 5mg AHR antagonist 2 CAS:2338747-54-7 AHR antagonist 2 is a potent aryl hydrocarbon receptor (AHR) antagonist, extracted from patent WO2019101641A1, compound example 1, with IC50s of 0.885 and 2.03 nM for human and mouse AhR. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.