Bioactive Small Molecules
Cayman Chemical ANTIBODY PRLX-93936 5mg
An erastin analog that has antitumor activity; inhibits the HIF-1 signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay); inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells at 1 μM; inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells (IC50s = <100 nM); inhibits tumor growth in PANC-1 and HT-1080 xenograft models at 50 mg/kg and induces tumor regression at 100 mg/kg
AdipoGen Dibenzylfluorescein (100 mg)
Chemical. CAS: 97744-44-0. Formula: C34H24O5. MW: 512.55. Dibenzylfluorescein is a fluorogenic probe that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19 and aromatase (CYP19). It is dealkylated by these CYP isoforms to produce fluorescein benzyl ether, which is further hydrolyzed to fluorescein by the addition of base (typically 2 M NaOH). Dibenzylfluorescein is typically used near its apparent Km value of 0.87-1.9 µM. The fluorescence of fluorescein is evaluated using excitation/emission wavelengths of 485/538nm. Dibenzylfluorescein is used to detect changes in CYP catalytic activity caused by drugs or disease.
AdipoGen 5-FAM
Chemical. CAS 76823-03-5. Formula C21H12O7. MW 376.32. Synthetic. The amine-reactive fluorescein derivatives are probably the most common fluorescent derivatization reagents for covalently labeling proteins. Carboxyfluorescein is better retained in cells than is fluorescein, its pKa of ~6.5 is lower than the cytosolic pH of most cells pH ~6.8-7.4. Carboxyfluorescein is commonly employed as a polar tracer.
AdipoGen Tadalafil (50 mg)
Chemical. CAS: 171596-29-5. Formula: C22H19N3O4. MW: 389.40. Tadalafil is a potent long-acting and selective inhibitor of the cGMP specific phosphodiesterase 5 (PDE5; IC50 = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 µM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury. Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, benign prostatic hyperplasia (BPH) and lower urinary tract dysfunction. Also delays tumor growth in a mouse model via inhibition of MDSC-mediated immunosuppression.
Cayman Chemical ANTIBODY NItrocefIn 1mg
A chromogenic cephalosporin substrate commonly used to detect β-lactamases in bacteria and other microbes
Cayman Chemical 4methylNEthylhexnophenon 5mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Cayman Chemical ANTIBODY Z944 25mg
A T-type calcium channel inhibitor (IC50s = 0.050-0.160 µM for human recombinant Cav3.1, Cav3.2, and Cav3.3); selective for T-type channels over the Cav2.2 channel (IC50 = 11 µM), as well as rat Cav1.2, hERG/Kv11.1, and human Nav1.5 channels (IC50s = 32, 7.8, and 100 µM, respectively); reduces seizure duration and the amount of time spent in seizures in a rat model of absence epilepsy at 30 mg/kg
Cayman Chemical ANTIBODY QX-77 25mg
An activator of chaperone-mediated autophagy; decreases paraquat- or oleic acid-induced MEF and Neuro2a cell death; rescues defective trafficking and lysosomal localization of the CMA receptor LAMP2A in Ctns-/- MEFs and CTNS knockout human proximal tubule cells at 20 µM
STEMCELL Technologies SU11274, Size: 1 mg
SU11274 is a selective, ATP-competitive inhibitor of MET receptor tyrosine kinase (IC₅₀ = 20 nM; Sattler et al.). It shows good selectivity towards MET versus other receptor tyrosine kinases with IC₅₀ values of 1.3 μM and 9.7 μM for kinase insert domain receptor (KDR) and fibroblast growth factor receptor-1 (FGFR1), respectively (Sattler et al.). It retains activity for certain MET mutants, for example H1112Y and M1268T (Berthou et al.).CANCER RESEARCH· Induces apoptosis and cell cycle arrest in TPR-MET-transformed mouse pre-B (Ba/F3) cells (Sattler et al.).· Inhibits cell viability and motility of human head and neck squamous cell carcinoma cell lines in vitro (Seiwert et al.). · Inhibits cell viability of c-MET-expressing human non-small cell lung carcinoma cell lines in vitro (Ma et al.).
Cayman Chemical ANTIBODY UprosertIb 25mg
A selective, orally bioavailable inhibitor of Akt (IC50s = 180, 328, and 38 nM for Akt1, Akt2, and Akt3, respectively); preferentially inhibits the proliferation of human cancer cells lines with Akt pathway activation via PI3K/PTEN mutation or loss
Cayman Chemical P3298hemIfumarate 5mg
A competitive transition-state substrate analog inhibitor of DPP IV (Ki = 126 nM); used to improve glucose tolerance, insulin sensitivity, and β-cell glucose responsiveness in diabetic rat models at 20 mg/kg/day
Medchemexpress LLC GSK-1292263 | 1032823-75-8 | 99.7% | 25 MG
GSK1292263 is an orally active GPR119 agonist used in research on glucagon-like peptide-1 secretion and glucose homeostasis relevant to type 2 diabetes mellitus. It is suitable for preclinical and in vitro studies where modulation of GPR119 is required.
- Orally available GPR119 agonist.
- Reported pEC50 6.9 (human) and 6.7 (rat).
- Molecular formula C23H28N4O4S; molecular weight 456.56 g/mol.
- High supplier-reported purity (~99.7%).
- Intended for research use in metabolic disease and glucose homeostasis studies.
Medchemexpress LLC Paulownin | 13040-46-5 | 1 MG
Paulownin is a chemical component found in the wood of Paulownia tomentosa Steud and is recognized as a constituent of medicinal plants. This product is intended strictly for research purposes.
- Component of Paulownia tomentosa Steud wood
- Constituent of medicinal plants
- Intended for research use only
- Not for sale to patients
Cayman Chemical MethoxphenIdInhydrochlorId 5mg
An analog of diphenidine featuring a methoxy group at the two position of a phenyl group
![Medchemexpress LLC 2-pyrrolidinone, 1-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-5-hydroxy | 2190490-31-2 | 402.81 | 5mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000269728.png-250.jpg)
Medchemexpress LLC 2-pyrrolidinone, 1-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-5-hydroxy | 2190490-31-2 | 402.81 | 5mg
Dacomitinib impurity 3 is an impurity of Dacomitinib (HY-13272)