Bioactive Small Molecules
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Filtered Search Results
![Medchemexpress LLC 1H-pyrido[3,4-b]indole derivative (GNE-149) | 1953132-75-6 | 99.2% | 503.57 | C28H33F4N3O | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000221247.png-250.jpg)
Medchemexpress LLC 1H-pyrido[3,4-b]indole derivative (GNE-149) | 1953132-75-6 | 99.2% | 503.57 | C28H33F4N3O | 5 MG
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GNE-149 is an orally bioavailable full antagonist of estrogen receptor α (ERα) and a selective estrogen receptor degrader (SERD) developed for research into ER-positive breast cancer. It exhibits potent ERα binding and induces receptor degradation, shows low-nanomolar antiproliferative activity in MCF7 and T47D cells, and has demonstrated efficacy in MCF7 xenograft models. Supplied as a solid for laboratory research use.
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![Medchemexpress LLC 2-[3-(3,5-dimethyltriazol-4-yl)-5-[(S)-oxan-4-yl(phenyl)methyl]pyrido[3,2-b]indol-7-yl]propan-2-ol | 1800340-40-2 | MFCD31544327 | 99.8% | 495.6 g/mol | C30H33N5O2 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000248947.png-250.jpg)
Medchemexpress LLC 2-[3-(3,5-dimethyltriazol-4-yl)-5-[(S)-oxan-4-yl(phenyl)methyl]pyrido[3,2-b]indol-7-yl]propan-2-ol | 1800340-40-2 | MFCD31544327 | 99.8% | 495.6 g/mol | C30H33N5O2 | 1 MG
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BMS-986158 (ezobresib) is an orally active small-molecule inhibitor of BET bromodomains used in oncology research. It binds the acetyl-lysine recognition pocket on BET proteins to disrupt chromatin-mediated transcription of oncogenes and has advanced into early clinical studies for hematologic and solid tumor indications.
- Potent cell-based activity (low-nanomolar IC50s in several cancer cell lines)
- BET bromodomain mechanism reduces expression of growth-promoting genes
- Demonstrated activity in small cell lung and triple-negative breast cancer models
- High chemical purity suitable for research applications
- Supplied in milligram quantities for preclinical experiments
- Chemical identifiers: CAS 1800340-40-2; formula C30H33N5O2
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Medchemexpress LLC Cyclosporin B | 63775-95-1 | 99.7% | 1188.58 | 5 MG
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Cyclosporin B is a group of nonpolar cyclic oligopeptides with immunosuppressive activity. It is used for the prevention of graft rejection in organ transplantation.
- Solid appearance
- White to off-white color
- Ships at room temperature in continental US
- Requires sealed storage, away from moisture and light
- Powder stable for 2 years at -80°C or 1 year at -20°C
- In solvent stable for 6 months at -80°C or 1 month at -20°C
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Medchemexpress LLC Ac-Nle-Pro-Nle-Asp-AMC | 355140-49-7 | 98.7% | 655.74 | 1 MG
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Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate primarily utilized for analyzing the caspase-like activity of the 26S proteasome.
- Specific substrate for 26S proteasome activity analysis.
- Used to study caspase-like activity.
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Cayman Chemical ANTIBODY GGTI 2418 5mg
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An inhibitor of GGTase I (IC50 = 9.5 nM); selective for GGTase I over FTase (IC50 = 53,000 nM); reduces tumor growth in an MDA-MB-231 breast cancer mouse xenograft model at 100 mg/kg
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Medchemexpress LLC HY-P1682A 5mg Medchemexpress, Balixafortide (TFA) CAS:0 Purity:>98%
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Medchemexpress, HY-P1682A 5mg Balixafortide (TFA) CAS:0 Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects[2]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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AAT BIOQUEST READIUSE TCEP REMOVAL SOL 1ML
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NC2333124 READIUSE TCEP REMOVAL SOL 1ML
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BROADPHARM EXATECAN-2-AMINOMETHOXY ACETAM
NC2586218 EXATECAN-2-AMINOMETHOXY ACETAM
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Cayman Chemical ANTIBODY CAY10704 10mg
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A potent inhibitor of HCV infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 µM); displays good pharmacokinetics in mice when delivered intraperitoneally, with preferential liver distribution without significant hepatotoxicity
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Cayman Chemical ANTIBODY BRD7116 25mg
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A selective inhibitor of leukemia stem cell activity (EC50 = 200 nM)
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REVIVE ORGANTECH CRYO-DMSO-F 100ML
NC2151611 CRYO-DMSO-F 100ML
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Medchemexpress LLC PACAP (1-38) free acid | 129405-61-4 | 99.9% | 4535.24 | 5 MG
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PACAP (1-38) free acid is a desamido-PACAP (1-38), which is human, ovine, and rat. It activates the human PAC1 receptor and induces cyclic AMP (cAMP) generation in both NS-1 neuroendocrine cells and non-neuroendocrine HEK293 cells. In vitro, it promotes neuroendocrine cell differentiation in NS-1 cells with an EC50 of 10.6 nM and induces cell growth arrest in NS-1 cells at concentrations of 0.1-300 nM.
- Activates human PAC1 receptor
- Induces cyclic AMP (cAMP) generation in NS-1 neuroendocrine cells
- Induces cyclic AMP (cAMP) generation in non-neuroendocrine HEK293 cells
- Promotes neuroendocrine cell differentiation in NS-1 cells
- Induces cell growth arrest in NS-1 cells
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eMolecules 60976-49-0 | Medchem Express | Geraniin | 5mg | 434310708 | HY-N0472 | 952.648 | C41H28O27
Medchem Express | Geraniin | 5mg | 434310708 | HY-N0472 | 60976-49-0 | 952.648 | C41H28O27
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Cayman Chemical ANTIBODY IsonIazId 50g
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An antibiotic that acts as a prodrug that is converted to isonicotinic acyl-NADH complex, which inhibits mycolic acid biosynthesis; effective against several species of Mycobacterium, including M. tuberculosis
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Medchemexpress LLC Pregnenolone acetate | 1778-02-5 | MFCD00003627 | 98.4% | 100 G
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Pregnenolone acetate is a nonmetabolized analog of Pregnenolone that promotes neurite extension and induces changes in growth cone morphology in primary cultures of cerebellar granule neurons. As a neurosteroid, it increases microtubule polymerization and holds potential for neurodevelopmental diseases research.
- Promotes neurite extension
- Induces change in growth cone morphology
- Increases microtubule polymerization
- Potential for neurodevelopmental diseases research
- Used in hormone replacement therapy research
- Explored for neuroprotection in diseases like Alzheimer's
- Suggested to modulate stress responses
- Investigated for anti-inflammatory applications
- Utilized in cosmetic formulations for skin health
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