Bioactive Small Molecules
Medchemexpress LLC HY-17371 100mg , Oxaliplatin CAS:61825-94-3 Purity:>98%
HY-17371 100mg Oxaliplatin CAS: 61825-94-3 Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-114384B 5mg , NV-5138 (hydrochloride) CAS: Purity:>98%
HY-114384B 5mg NV-5138 (hydrochloride) CAS: NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride is used for antidepressant studies. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-131296 5mg , 5-A-RU-PABC-Val-Cit-Fmoc CAS:2677841-58-4 Purity:>98%
HY-131296 5mg 5-A-RU-PABC-Val-Cit-Fmoc CAS: 2677841-58-4 5-A-RU-PABC-Val-Cit-Fmoc is the prodrug of 5-A-RU. 5-A-RU, a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules, such as glyoxal and methylglyoxal, which are derived from other metabolic pathways[4]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-10396 50mg , Emricasan CAS:254750-02-2 Purity:>98%
HY-10396 50mg Emricasan CAS: 254750-02-2 Emricasan (PF 03491390) is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Protoporphyrin IX, 100mg CAS# 553-12-8
Protoporphyrin IX is a member of porphyrin family, which belongs to tetrapyrroles. It is the precursor of heme in biosynthetic pathway. Protoporphyrin IX can be used in protoporphyrin assays, fluorescence spectra analysis and heme-mediated ferroportin 1 transcription study. Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC L-Mimosine, 250mg CAS# 500-44-7
L-mimosine is a prolyl 4-hydroxylase inhibitor and acts as an iron chelator [1]. In rats, it interfered with the reconstitution of the active human prolyl 4-hydroxylase with an IC50 value of 120 M [2].Prolyl 4-hydroxylase (EC 1.14.11.2) is an 22 tetramer. It catalyses the formation of 4-hydroxyproline in coliagen via the hydroxylation of proline residues in the peptide linkage [3]. Prolyl-4-hydroxylase domain-containing protein (PHD) regulates HIF-1 levels in renal medulla and participates in controlling renal Na+ excretion [4].L-mimosine acted as an inhibitor for prolyl 4-hydroxylase in cultured vascular cells. L-mimosine dose-dependently inhibited the activity of prolyl hydroxylase in rat and human smooth muscle cells (SMC) and at concentrations of 400-500 M decreased hydroxyprolyl generation by 80-90%. Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC 2'3'-cGAMP (sodium salt), 1mg CAS# 1441190-66-4
2,3-cGAMP (sodium salt) is a second messenger generated by the enzyme cGAMP synthase (cGAS) in the cytoplasm of mammalian cells, in response to the presence of double-stranded DNA. As a second messenger, 2,3-cGAMP sodium salt activates innate immune responses via binding of STING (stimulator of IFN genes) and initiates the TBK1-IRF3-dependent production of IFN-. It is used to identify small compounds that bind to STING. It is also applicable in the research of type I interferon response to cytosolic DNA. The binding affinity of 2,3-cGAMP to STING is 3.79 nM (Kd value), which is stronger than other cyclic di-nucleotides, e.g. cyclic di-GMP, 32-cGAMP, 33-cGAMP and 22-cGAMP (Kds = 1.21 M, 1.61 M, 1.04 M and 287 nM, respectively). Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC Biotin-XX Tyramide Reagent, 100mg. Cas: MFCD: NA. Reagent used for tyramide signal amplification (TSA)
Biotin-LC-LC-tyramide is used for tyramide signal amplification (TSA) which is a powerful, patented technology that significantly enhances both chromogenic and fluorescent signals. TSA is easily integrated into standard nonradioactive in situ hybridization (ISH) or IHC protocols.TSA is an enzyme-mediated detection method that uses horseradish peroxidase (HRP) to catalyze the deposition of a fluorophore-labeled tyramide amplification reagent onto tissue sections or cell preparation surfaces that have been previously blocked with proteins. Biotin-LC-LC-tyramide use horseradish peroxidase (HRP) to catalyze covalent deposition of biotin labels directly adjacent to the immobilized enzyme. The labeling reaction is quick (less than 10 minutes) and deposited labels can be detected with streptavidin conjugates for imaging in brightfield or fluorescence microscopy. Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC Tubastatin A HCl, 10mM (in 1mL DMSO) CAS# 1310693-92-5
Tubastatin A HCl is a selective inhibitor of HDAC6 with IC50 value of 15 nM [1]. HDAC6 (histone deacetylase 6) is an enzyme and plays an important role in a variety of processes, including transcriptional regulation, cell cycle preogression and developmental events. Abnormal expression of HDAC6 is correlated with many kinds of diseases, including Alzheimer's disease and cancers [1]. Tubastatin A HCl is a potent HDAC6 inhibitor and has the most selective compared with other HDAC isoforms. When tested with primary cortical neuron cells, Tubastatin A HCl treatment protected HCA-induced neuronal cell death in a dose range from 5 M to 10 M. Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC Cy5-UTP, 25ul (10mM). Cas: MFCD: NA. used as a substrate for T7 RNA polymerase and generate labeled probes through in vitro transcription
Cy5-UTP (Cyanine 5-UTP) can replace UTP as a substrate for T7 RNA polymerase and generate labeled probes through in vitro transcription. The resulting assembled mRNA will emit orange fluorescence with the involvement of Cy5-UTPs. In addition, Cy5-labeled mRNA is readily visible under ultraviolet light without further staining after gel electrophoresis. Probes generated by these methods are suitable for various application, such as FISH, multicolor fluorescence analysis, specifically dual-color expression arrays in conjunction with Cy5-UTP. Excitation/Emission (nm): 650/665 nm Other sizes are also available. Please inqury us for quote.
Medchemexpress LLC HY-125840 10mg , Belzutifan CAS:1672668-24-4 Purity:>98%
HY-125840 10mg Belzutifan CAS: 1672668-24-4 Belzutifan (PT2977) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. Belzutifan, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. Belzutifan is a potential treatment for clear cell renal cell carcinoma (ccRCC). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-B1756 500mg , Rotenone CAS:83-79-4 Purity:>98%
HY-B1756 500mg Rotenone CAS: 83-79-4 Rotenone is an mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-129905A 5mg , L-Leucyl-L-Leucine methyl ester (hydrobromide) CAS:16689-14-8 Purity:>98%
HY-129905A 5mg L-Leucyl-L-Leucine methyl ester (hydrobromide) CAS: 16689-14-8 L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-16950 10mg , 4-Hydroxytamoxifen CAS:68047-06-3 Purity:>98%
HY-16950 10mg 4-Hydroxytamoxifen CAS: 68047-06-3 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) induces CRISPR/Cas9 systems based on ER mediated nucleus translocation[4]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-15310 1g , Ivermectin CAS:70288-86-7 Purity:>98%
HY-15310 1g Ivermectin CAS: 70288-86-7 Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import[4]. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19[5]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.