Bioactive Small Molecules
Medchemexpress LLC S961 acetate | 99.83% | 4802.12 | 50 MG
S961 acetate is a high-affinity and selective antagonist of the insulin receptor (IR). It exhibits IC50 values of 0.048 nM for HIR-A, 0.027 nM for HIR-B, and 630 nM for human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay. It also demonstrates high-affinity for Rat IR and Pig IR with IC50s of 0.056 nM and 0.084 nM, respectively, in PEG-assay.
- High-affinity and selective antagonist of the insulin receptor.
- Targets HIR-A, HIR-B, HIGF-IR, Rat IR, and Pig IR.
AdipoGen 8-OH-6Me-pyrene-trisulfonamide
Chemical. CAS 127044-59-1. Formula C22H25N3O7S3. MW 539.64. Synthetic. Fluorescent pH indicator for the weakly acidic pH range and enzyme substrate reference standard.
AdipoGen 6-IAF
Chemical. CAS 73264-12-7. Formula C22H14INO6. MW 515.25. Synthetic. Fluorescent reagent with high selectivity.
Selleck Chemical LLC NX-1607 E1957-100MG
NX-1607 (Cbl-b-IN-3) is an oral inhibitor of Casitas B-lineage lymphoma proto-oncogene B (CBL-B) which is an E3 ubiquitin ligase and a key regulator of T NK and dendritic cell activation and suppresses their anti-tumor functions NX-1607 enhances antigen recall reduces T cell exhaustion and increases cytokine production in response to T cell receptor stimulation thereby counteracting suppressive signals from the tumor microenvironment
AdipoGen 2-Naphthyl-2-pentyloxy-MeCN
Chemical. CAS 500372-26-9. Formula C17H19NO. MW 253.34. Synthetic. Fluorescent dye label, probe, stain.
![Medchemexpress LLC 1,3-dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl)methylene]-1H-indol-2-one | 269730-03-2 | MFCD03852474 | 99.3% | 297.31 g/mol | C17H15NO4 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211137.png-250.jpg)
Medchemexpress LLC 1,3-dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl)methylene]-1H-indol-2-one | 269730-03-2 | MFCD03852474 | 99.3% | 297.31 g/mol | C17H15NO4 | 25 MG
RPI-1 is a research-grade 2-indolinone inhibitor of RET tyrosine kinase that inhibits RET phosphorylation and downstream signaling (PLCγ, ERKs, AKT) and shows antiproliferative activity in RET-driven tumor cell models. It is supplied as a solid powder for laboratory research use only.
- Mechanism: inhibits RET tyrosine kinase and downstream signaling.
- Purity: 99.29% (manufacturer reported).
- Molecular formula: C17H15NO4; molecular weight: 297.31 g/mol.
- Physical form: solid powder suitable for solution preparation.
- Storage: powder -20°C for long-term, 4°C for short-term; in solvent store at -80°C when possible.
- Intended use: for research use only, not for human or clinical use.
Cayman Chemical JNJ-64619178 1mg
A PRMT5 inhibitor (IC50 = 0.14 nM); inhibits the growth of various cancer cells in vitro and reduces tumor growth in NSCLC and SCLC mouse xenograft models
Cayman Chemical ANTIBODY GSK1292263 10mg
A GPR119 agonist (EC50 = 43.9 nM in CHO-K1 cells expressing human GPR119); inhibits T0901317-induced increases in SREBP-1 levels and increases activation of AMPK in HepG2 cells in a concentration-dependent manner; inhibits BCRP and OATP1B1 by 52 and 40%, respectively, at 3 μM
Cayman Chemical EthylenoxynItazencItrate 5mg
An analytical reference standard that is structurally similar to known opioids; intended for research and forensic applications
Medchemexpress LLC Acetyl tributyl citrate | 77-90-7 | 99.0% | 402.48 | 5 MG
Acetyl tributyl citrate, also known as Tributyl O-acetylcitrate, is a pharmaceutical excipient and a biodegradable hydrophobic plasticizer. It is rapidly metabolized in rat plasma, rat and human liver microsomes, with significant activity from CYP2C19 and CYP3A4. It also shows rapid absorption and elimination in rats with an oral bioavailability of 27.4%.
- Utilized in cosmetics
- Used in food packaging
- Functions as a flavoring substance for food
Medchemexpress LLC BMS-599626 (morpholin-3-ylmethyl carbamate) | 714971-09-2 | MFCD10565678 | 98.6% | 530.6 g/mol | C27H27FN8O3 | 50 MG
BMS-599626 (AC480) is a pan-HER kinase inhibitor used in research to target EGFR (HER1) and HER2 signaling. It is supplied as a white to off-white solid with high reported purity and recommended cold storage for stability.
- Inhibits HER1 and HER2 with IC50s ≈ 20 nM and 30 nM respectively.
- White to off-white solid with high purity (>98%).
- Suitable for biochemical, cellular, and in vivo research applications.
- Recommended storage: powder at -20°C for long term, 4°C for shorter storage.
- Provided in milligram-scale packaging for research use.
Medchemexpress LLC HY-101175 10mg Medchemexpress, 3-Bromo-7-nitroindazole CAS:74209-34-0 Purity:>98%
Medchemexpress, HY-101175 10mg 3-Bromo-7-nitroindazole CAS:74209-34-0 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY MRS1754 25mg
An adenosine A2B receptor antagonist (Ki = 1.97 nM); selective for adenosine A2B receptors over adenosine A1, A2A, and A3 receptors (Kis = 403, 503, and 570 nM, respectively); increases 28-day survival, as well as decreases peritoneal bacterial growth and plasma levels of IL-6, TNF-α, and MIP-2, in a mouse model of CLP-induced sepsis from 0.5-10 mg/kg; reduces disease severity in a mouse model of EAE at 1 mg/kg