Bioactive Small Molecules
Apexbio Technology LLC Sodium Picosulfate, 50mg. Cas: 10040-45-6 MFCD: MFCD00867640. laxative
Sodium Picosulfate is a laxative. Sodium Picosulfate is a laxative that inhibits water and electrolytes absorption and increases their secretion. Other sizes are available. Please inqury us for quote.
Cayman Chemical ChlorphenIramIn-d6maleate 5mg
An internal standard for the quantification of chlorpheniramine by GC- or LC-MS
Medchemexpress LLC ETP-45658 | 1198357-79-7 | 99.0% | 311.34 | 1 ML
ETP-45658 is a potent PI3K inhibitor, with IC50s of 22.0 nM, 39.8 nM, 129.0 nM and 717.3 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. It also can inhibit DNA-PK (IC50=70.6 nM) and mTOR (IC50=152.0 nM). ETP-45658 can be used for the research of cancer.
- IC50 & Target:
- PI3Kα: 22.0 nM (IC50)
- PI3Kδ: 39.8 nM (IC50)
- PI3Kβ: 129.0 nM (IC50)
- PI3Kγ: 717.3 nM (IC50)
- DNA-PK: 70.6 nM (IC50)
- mTOR: 152.0 nM (IC50)
- In Vitro:
- Decreases in the phosphorylation of FOXO3a, Gsk3-β and p70 S6K in U2OS cells.
- Inhibits the proliferation of MCF7, PC3, 786-O, HTC116, and U251 cells.
- Induces a clear G1 arrest of PC3 cells.
- Inhibits the mutant PI3Kα proteins, H1047R and E545K.
- Induces a dose-dependent increase of GFP-FOXO nuclear translocation in U2foxRELOC cells.
- Decrease the expression of cyclin D1 and p-Akt on serine 473 in U2OS cells.
Medchemexpress LLC HY-139441 5mg , DM21 CAS:2243689-80-5 Purity:>98%
HY-139441 5mg DM21 CAS: 2243689-80-5 DM21 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
AdipoGen PP1 (5 mg)
Chemical. CAS: 172889-26-8. Formula: C16H19N5. MW: 281.4. Highly potent and selective Scr family tyrosine kinase inhibitor. Shows anti-Ras cancer potential by blocking Ras-induced activation of PAK1. Antitumor compound. RIP2 inhibitor. Blocks TGF-beta-mediated cellular responses.
Selleck Chemical LLC Orientin S9099-5MG
Orientin (Lutexin Luteolin-8-glucoside) isolated from medicinal plants has various activities including anti-oxidant anti-aging anti-viral anti-bacterial anti-inflammation vasodilatation and cardioprotective antiadipogenesis antinociceptive radiation protective neuroprotective and antidepressant-like effects
Selleck Chemical LLC 4-Hydroxyestrone E8109-1MG
4-Hydroxyestrone (4-OHE1) an estrone metabolite has strong neuroprotective effect against oxidative neurotoxicity 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53 4-Hydroxyestrone has little estrogenic activity
Selleck Chemical LLC Diltiazem E7160-100MG
Diltiazem (Dilzen CRD-401) is a benzothiazepine an antagonist of Ca2 channel inhibiting L-type Ca currents via CaV1 2 channels in cardiac and vascular smooth muscle It can be used in research of cardiac arrhythmia hypertension and angina pectoris
Selleck Chemical LLC DL-Alanine E4832-1G
DL-alanine (DL-2-Aminopropionic acid) is a racemic mixture of L- and D-alanine that forms complexes with transition metals like Cu(II) Zn(II) and Cd(II) It also plays a key role in the glucose-alanine cycle between tissues and the liver
Selleck Chemical LLC Melevodopa hydrochloride E4010-25MG
L-3 4-Dihydroxyphenylalanine methyl ester hydrochloride(Melevodopa hydrochloride) is a precursor to L-DOPA It is an antiparkinsonian agent L-DOPA methyl ester that elicits antitumor functionality in leukemia and melanoma
Selleck Chemical LLC Lobaplatin S8880-1MG
Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent It is a platinum complex with DNA alkylating activity DMSO is not recommended to dissolve platinum-based drugs which can easily lead to drug inactivation
Selleck Chemical LLC AZD8797-E1616-1G
AZD8797 (KAND567) is an allosteric non-competitive and orally active antagonist of the human receptor CX3CR1 It antagonizes CX3CR1 with a Ki value of 3 9 nM respectively It effects G-protein signaling and -arrestin recruitment
Selleck Chemical LLC Dexketoprofen trometamol E4807-100MG
Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally active non-selective inhibitor of COX Dexketoprofen trometamol exhibits analgesic efficacy and can be used in treating acute pain
Medchemexpress LLC Ribocil | 1381289-58-2 | 99.6% | 382.48 | 50 MG
Ribocil | 1381289-58-2 | 99.6% | 382.48 | 50 MG
Medchemexpress LLC Fluoflavine | 531-46-4 | 99.4% | 234.26 g/mol | C14H10N4 | 25MG
Fluoflavine is a small-molecule research compound that selectively inhibits NADPH oxidase 1 (NOX1). It is used in biochemical and cellular studies to probe NOX1-mediated reactive oxygen species production. The compound exhibits potent enzymatic inhibition and demonstrable cellular activity, and is supplied in small milligram quantities with high analytical purity.
- Selective NOX1 inhibition with IC50 of 90 nM.
- Greater than 100-fold selectivity over NOX2, NOX3, and NOX4 (IC50 >10 μM).
- Cellular activity: IC50 of 360 nM in HEK293 cells.
- High analytical purity (99.41%).
- Available in small milligram pack sizes suitable for research assays.
- Molecular formula C14H10N4 and molecular weight 234.26 g/mol.