Bioactive Small Molecules
Medchemexpress LLC Dodecyltrimethylammonium bromide | 1119-94-4 | 99.9% | 25 G
Dodecyltrimethylammonium bromide (DTAB) is a surfactant that interacts with DNA, changing its mechanical properties upon binding and influencing specific binding parameters. It is intended for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Selleck Chemical LLC EI1 5mg 1418308-27-6
EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
TARGETMOL CHEMICALS INC BMS-P5 free base 10MG
Also available in 1 mL, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor that blocks the formation of Neutrophil Extracellular Traps and delays the progression of multiple myeloma. Administration of BMS-P5 to multiple myeloma-bearing mice delays symptom onset and disease progression. Targeting PAD4 may be beneficial for treating multiple myeloma. Purity 99.96%
Medchemexpress LLC MRGPRX1 agonist 1 | 2377379-39-8 | 99.95% | 1 ML
MRGPRX1 agonist 1 is a highly potent and selective agonist for MRGPRX1, with an EC50 of 50 nM. It exhibits over 50-fold selectivity compared to δ, μ, and κ opioid receptors and is inactive against MRGPRC11. This compound is valuable for studying chronic pain, particularly neuropathic pain.
- Highly potent MRGPRX1 agonist
- Greater than 50-fold selectivity for δ, μ, and κ opioid receptors
- Inactive against MRGPRC11
- Useful for the study of chronic pain
- EC50 of 50 nM for MRGPRX1
- Inhibits high voltage-activated (HVA) Ca2+ currents
- Reduces neurotransmitter release
- Mitigates nociceptive transmission in the spinal cord
- Shows good distribution to the spinal cord in male mice
Medchemexpress LLC C.I. Pigment red 123 | 24108-89-2 | 98.0% | 25 G
C.I. Pigment red 123 is a significant colorant used to add or alter the color of materials. It is chemically stable and largely unaffected by the carrier or medium in which it is incorporated.
- Used as a colorant in multiple industries (textile, medicine, food, cosmetics, plastics, paint, ink, photography, paper).
- Chemically unaffected by the carrier or medium.
Selleck Chemical LLC GNE-049
GNE-049 is a highly potent and selective inhibitor of CBP It exhibits an IC50 of 1 1 nM in TR-FRET assay GNE-049 also effectively inhibits BRET and BRD4 with IC50 values of 12 nM and 4200 nM respectively
Selleck Chemical LLC Adenosine Cyclophosphate S9370-1G
Adenosine Cyclophosphate (Cyclic adenosine monophosphate cAMP cyclic AMP 3 5 -cyclic adenosine monophosphate) is useful for improving myocardial hypoxia dilating coronary artery and strengthening myocardiac contraction
Cayman Chemical ANTIBODY GSK2982772 1mg
A RIPK1 inhibitor (IC50s = 16 and 2,500 nM for the human and mouse enzymes, respectively); >10,000-fold selective for RIPK1 over a panel of 339 kinases at 10 µM; inhibits necrotic cell death induced by a combination of TNF-α and the caspase inhibitor QVD-OPh in U937 human monocytic and L929 murine fibrosarcoma cells (IC50s = 6.3 and 1,300 nM, respectively); decreases IL-1β and IL-6 levels in intestinal mucosa tissue isolated from patients with ulcerative colitis at 3-300 nM; increases survival in a mouse model of TNF-α-induced lethal shock at 3, 10, and 50 mg/kg
TARGETMOL CHEMICALS INC DCBP-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing. purity: 98%
Medchemexpress LLC Animal-free BMP-3 protein, human (His) | 95.0% | 10UG
Recombinant human bone morphogenetic protein 3 (BMP-3) with a C-terminal His tag, expressed in E. coli and supplied as an animal-free recombinant protein for research and cell culture use. The preparation corresponds to the mature BMP-3 region (residues Q363-R472) and is provided in small laboratory quantities suitable for in vitro assays.
- Animal-free recombinant human BMP-3 with C-terminal His tag.
- Expressed in E. coli for consistent, non-glycosylated production.
- Corresponds to the mature BMP-3 sequence (residues Q363-R472).
- Provided in small laboratory quantity suitable for cell culture and in vitro assays.
- High purity suitable for biological assays (>95% reported by distributor).
Cayman Chemical ANTIBODY FurosemIde 1g
A loop diuretic and an inhibitor of NKCC1 and NKCC2 (Kis = ~10 µM for both); increases diuresis in beagle dogs at 0.1 mg/kg; reduces ventricular collagen deposition and fibrosis in a rat model of dilated cardiomyopathy at 30 mg/kg
Apexbio Technology LLC Docetaxel Trihydrate 148408-66-6 50mg
Docetaxel Trihydrate (CAS 148408-66-6) is a semisynthetic taxane derivative that interferes with cell division by binding to and stabilizing microtubules thereby inhibiting their depolymerization This action disrupts mitotic spindle function leading to cell cycle arrest and apoptosis In vitro studies demonstrate that docetaxel exhibits variable cytotoxicity across cancer cell lines with IC50 values ranging from 0 13 to 3 3 ng/ml Unlike paclitaxel docetaxel-induced gene expression changes are predominantly associated with cell surface receptor-mediated signaling cytokine interactions and cell cycle regulation Docetaxel Trihydrate is widely utilized in oncology research and preclinical models investigating mitotic inhibitors and mechanisms of chemoresistance
Cayman Chemical 1 3-DIdecnoyl Glycerol 5mg
A saturated diacylglycerol; has been used in the formation of lipid monolayers in the study of lipases