Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical Lisinopril, Purity: ≥98%, CAS: 76547-98-3, 100 mg
An ACE inhibitor (IC50 = 1.2 nM); reduces the formation of endothelin-1 and increases NO in human vascular endothelial cells at 0.1 nM; inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID50s = 2.3 and 6.5 µg/kg, respectively)
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AdipoGen KN-93 (water soluble) (1 mg)
KN-93 (water soluble) (1 mg), AdipoGen Life Sciences. Chemical. CAS: 1188890-41-6 | 139298-40-1 (free base). Formula: C26H29ClN2O4S . H3PO4. MW: 501.0 . 98.0. Selective Ca2+/calmodulin-dependent protein kinase II inhibitor. Insulin release inhibitor. Acid secretion inhibitor. G1 cell cycle arrest inducer. Apoptosis inducer. Ion channel inhibitor. ROS inducer. Androgen receptor inhibitor.
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AdipoGen Lactacystin (500 µg)
Lactacystin (500 µg), AdipoGen Life Sciences. Chemical. CAS: 133343-34-7. Formula: C15H24N2O7S. MW: 376.4. Isolated from Streptomyces lactacystinnaeus strain OM-6519. Induces neuritogenesis. Potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex). Blocks proteasome activity by targeting the catalytic beta-subunit. Apoptosis inducer. Anticancer compound. Upregulates HSP70 and HSP22. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Inhibits NF-kappaB activation by inhibiting IkappaB degradation. Cathepsin A inhibitor. beta-Secretase activity inhibitor. Anti-adipogenic. Autophagy inducer.
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Lkt Laboratories ABT-199, ≥98%, 1MG
BH3 mimetic; Bcl-2 inhibitor. CAS: 1257044-40-8. Additional sizes available upon request. Ships from Saint Paul, MN.
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AdipoGen Citrinin (25 mg)
Chemical. CAS: 518-75-2. Formula: C13H14O5. MW: 250.3. Isolated from Penicillium citrinum strain FKI-4836. Antibiotic. Antiprotozoal. Antimicrobial. Cytotoxic and genotoxic in various mammalian cells. Mitochondrial permeability transition pore (MPTP) activator. Apoptosis inducer. ERK and JNK signaling pathways activator. Nephrotoxic mycotoxin. Suppresses NO and iNOS expression via inhibition of the JAK/STAT-1alpha and NF-kappaB signaling pathways. Tubulin polymerization and mitotic spindle assembly inhibitor. Increases reactive oxygen species (ROS). Induces cell cycle arrest at the G0/G1 and G2/M phase.
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AdipoGen Heliquinomycin (250 µg)
Chemical. CAS: 178182-49-5. Formula: C33H30O17. MW: 698.6. Isolated from Streptomyces sp. MJ929-SF2. Antibiotic. DNA helicase inhibitor. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex. Topoisomerase I and II inhibitor (weaker than DNA helicase). DNA and RNA synthesis inhibitor in cell culture. Does not inhibit protein synthesis. Induces cell cycle arrest. Anticancer compound. Antibacterial against Gram-positive bacteria.
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AdipoGen Makisterone A (1 mg)
Chemical. CAS: 20137-14-8. Formula: C28H46O7. MW: 494.7. Isolated from Ipomoea hederacea. A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Plays a role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP). Appears in plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. Could be used for controlled gene expression in scientific research, agriculture and medicine. Could be used for the development of selective insect growth regulators for use as environmentally benign insecticides.
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AdipoGen Asiaticoside (50 mg)
Chemical. CAS: 16830-15-2. Formula: C48H78O19. MW: 959.1. Isolated from Centella asiatica. Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor.
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AdipoGen Lariatin A (250 µg)
Chemical. CAS: 732286-09-8. Formula: C94H143N27O25. MW: 2051.4. Isolated from Rhodococcus jostii. Peptide with lasso structure. Antimycobacterial.
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AdipoGen Rugulosin (250 µg)
Chemical. CAS: 23537-16-8. Formula: C30H22O10. MW: 542.5. Isolated from Penicillium sp. Antibiotic. Antibacteriophage. Antiviral. Mycotoxin. DNA replication, transcription and repair inhibitor. Antibacterial. RNA polymerase and ribonuclease H inhibitor. Insecticidal. Cytotoxic. HIV-1 integrase inhibitor. Shows anti-MRSA (methicillin-resistant Staphylococcus aureus) activity. Potential Hsp90 inhibitor through interacting with N-Hsp90.
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AdipoGen Penicillide (250 µg)
Chemical. CAS: 55303-92-9. Formula: C21H24O6. MW: 372.4. Isolated from Penicillium sp. Plant growth inhibitor. Acyl-CoA-cholesterol acyltransferase (ACAT) inhibitor. Anticancer compound. Cytotoxic. Non-peptidic oxytocin receptor antagonist. Calpain inhibitor.
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AdipoGen Terpendole C (1 mg)
Chemical. CAS: 156967-65-6. Formula: C32H41NO5. MW: 519.7. Isolated from Albophoma yamanashiensis. Acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor. Tremorgenic. Cholesteryl ester (CE) synthesis inhibitor.
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Cayman Chemical PF-04981517, Purity: ≥98%, CAS: 1390637-82-7, 5 mg
A potent, selective, and time-dependent inhibitor of CYP3A4 (IC50 = 30 nM)
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Cayman Chemical ML-228, Purity: ≥95%, CAS: 1357171-62-0, 5 mg
An activator of the HIF signaling pathway, as demonstrated by HRE reporter assay (EC50 = 1.2 µM), HIF-1α nuclear translocation assay (EC50 = 1.3 µM), and increased VEGF expression (EC50 = 1.6 µM); activity is blocked by excess iron, suggesting that ML-228 can chelate iron
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Cayman Chemical ONO-AE3-208, Purity: ≥98%, CAS: 402473-54-5, 5 mg
An antagonist of the EP4 receptor (Ki = 1.3 nM) which less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors; implicates EP4 signaling in immune and autoimmune responses, inflammation, and cancer
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