Protein Modification Reagents
Kyfora Bio Polyethylene glycol MW 400
Polyethylene glycol (PEG) is a water-soluble biologically inert polymer that has a number of biological and pharmaceutical applications Specifically PEG400 can be used as an excipient in pharmaceutical products or as a coating on nanoparticles to prevent opsonization in vivo It can also be used for purification of plasmid DNA The polymer chains are hydroxyl terminated at both ends
Medchemexpress LLC DBCO-PEG12-maleimide | 00-00-0 | 98.0% | C52H74N4O17 | 10MG
DBCO-PEG12-maleimide is a PEG12-based bifunctional linker for bioconjugation and PROTAC synthesis. It combines a dibenzocyclooctyne (DBCO) moiety for strain-promoted alkyne-azide cycloaddition and a maleimide group for selective thiol conjugation, providing a flexible, hydrophilic spacer for assembling complex conjugates. Supplied as a high-purity reagent for research use.
- Enables copper-free click chemistry via strain-promoted alkyne-azide cycloaddition.
- Provides thiol-selective conjugation through a maleimide reactive handle.
- Offers a PEG12 spacer to increase solubility and reduce steric hindrance.
- High purity suitable for research applications.
- Stable when stored under recommended conditions.
Medchemexpress LLC DBCO-PEG4-DBCO | 2182601-68-7 | 97.4% | 1 G
DBCO-PEG4-DBCO is a PEG-based PROTAC linker used in the synthesis of PROTACs. It also functions as a cleavable ADC linker for synthesizing antibody-drug conjugates (ADCs) and is a click chemistry reagent, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- PEG-based PROTAC linker
- Cleavable ADC linker
- Click chemistry reagent
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
eMolecules 125274-16-0 | Tr-PEG5 | Broadpharm | MFCD22574816 | 436.548 | C27H32O5 | 98.000 | OCCOCCOCCOCCOC(c1ccccc1)(c1ccccc1)c1ccccc1 | 1g | 112541223
Tr-PEG5 | Broadpharm | 125274-16-0 | MFCD22574816 | 436.548 | C27H32O5 | 98.000 | OCCOCCOCCOCCOC(c1ccccc1)(c1ccccc1)c1ccccc1 | 1g | 112541223
STA PHARMACEUTICAL US LLC Azide-PEG3-L-alanine-Fmoc | 25 g | CAS 2054345-69-4 | InChIKey YTHKPQSMRZQREU-JOCHJYFZSA-N
Azide-PEG3-L-alanine-Fmoc is a Amino Acid reagent (Subcategory: Azido/Alkynyl AA) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 2054345-69-4
- MDL: No data
- InChIKey: YTHKPQSMRZQREU-JOCHJYFZSA-N
- Molecular Weight: 484.509
- Molecular Formula: C24H28N4O7
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29299090
- Country Of Origin: China
- IUPAC: N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-D-serine
- SMILES: O=C(N[C@H](COCCOCCOCCN=[N+]=[N-])C(O)=O)OCC1C2=C(C=CC=C2)C3=C1C=CC=C3
Medchemexpress LLC DSPE-PEG-biotin, MW 3400 | 98.4% | 3400 (average) | 250 MG
DSPE-PEG-Biotin, MW 3400 is a PEGylated phospholipid supplied as a white powder. The DSPE lipid tail anchors in membranes or liposomes while the PEG3400 spacer presents biotin for high-affinity capture, detection, or targeted delivery applications. The product is listed with an average molecular weight of 3400 and a reported purity of 98.43%.
- Provides biotin functional groups for streptavidin/avidin-based capture and detection.
- An amphiphilic structure that anchors efficiently into lipid bilayers and liposomes.
- PEG3400 spacer improves aqueous solubility and reduces nonspecific interactions.
- Available in multiple pack sizes for small- and preparative-scale work.
- Stable as a powder at -20°C; in-solution storage recommendations provided for longer-term stability.
Medchemexpress LLC Azido-PEG5-CH2CO2H | 217180-81-9 | 98.9% | 321.33 g/mol | C12H23N3O7 | 100 MG
Azido-PEG5-CH2CO2H is a cleavable, azide-functional polyethylene glycol (PEG) linker containing five ethylene glycol units. It is intended for use in antibody-drug conjugate (ADC) and PROTAC synthesis, and it functions as a click-chemistry reagent for copper-catalyzed and strain-promoted azide-alkyne cycloadditions.
- Cleavable PEG5 linker suitable for ADC and PROTAC synthesis.
- Azide functional group for copper-catalyzed and strain-promoted azide-alkyne cycloadditions.
- Molecular weight 321.33 g/mol and formula C12H23N3O7.
- Purity 98.9%.
- Appearance: liquid; store protected from light at -20°C; in solvent: -80°C up to 6 months, -20°C up to 1 month.
- Common packaging: 25 mg, 50 mg, 100 mg, 250 mg, 500 mg, 1 g.
Broadpharm Fmoc-N-amido-PEG4-acid.CAS:557756-85-1.Formula: C26H33NO8
Fmoc-N-amido-PEG4-acid.CAS:557756-85-1.Formula: C26H33NO8
eMolecules 658858-65-2 | THP-PEG9 | Broadpharm | MFCD29764333 | 454.557 | C21H42O10 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOC1CCCCO1 | 1g | 303671227
THP-PEG9 | Broadpharm | 658858-65-2 | MFCD29764333 | 454.557 | C21H42O10 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOC1CCCCO1 | 1g | 303671227
Medchemexpress LLC DOTA-PEG5-C6-DBCO | 94.0% | C49H71N7O14 | 50 MG
DOTA-PEG5-C6-DBCO is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent containing a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have Azide groups. PROTACs utilize the intracellular ubiquitin-proteome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains a DBCO group
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Degrades target proteins via the ubiquitin-proteasome system
- Off-white to light yellow solid
- Soluble in DMSO and H2O
Medchemexpress LLC M-PEG-mal (MW 2000) | 97.27% | 100 MG
M-PEG-mal (MW 2000) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs are innovative molecules that harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins, utilizing two different ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other for the protein of interest.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB-OH | 2055041-39-7 | MFCD29918232 | 96.9% | 706.78 g/mol | C33H50N6O11 | 50 MG
Mal-PEG4-Val-Cit-PAB-OH is a cleavable four-unit polyethylene glycol (PEG) linker used to connect an antibody and a cytotoxic payload in antibody-drug conjugate (ADC) synthesis. It contains a maleimide reactive group for thiol coupling, a PEG4 spacer, a Val-Cit protease-cleavable dipeptide, and a para-aminobenzyl (PAB) self-immolative spacer that enables intracellular release of payloads.
- Cleavable four-unit PEG linker enabling protease-mediated release.
- Maleimide functional group for thiol conjugation.
- Val-Cit dipeptide designed for cathepsin B cleavage.
- PAB self-immolative spacer to promote efficient payload release.
- Suitable for ADC synthesis and bioconjugation workflows.
Medchemexpress LLC NH-bis-PEG4 | 63721-14-2 | 98.0% | C16H35NO8 | 250 MG
NH-bis-PEG4 is a PEG-based PROTAC linker. It is primarily used in the synthesis of PROTACs.
- Store in pure form at -20°C for up to 3 years or 4°C for up to 2 years.
- When in solvent, store at -80°C for up to 6 months or -20°C for up to 1 month.
Medchemexpress LLC Tamra-PEG4-acid | 1909223-02-4 | MFCD31536753 | 95.3% | C36H43N3O10 | 10MG
TAMRA-PEG4-acid is a red-fluorescent dye bearing a PEG4 spacer and a terminal carboxylic acid, formulated for covalent labeling of biomolecules and probe synthesis. It offers a hydrophilic linker to reduce steric interference and improve solubility, and is provided at high purity for analytical and imaging workflows.
- Provides red fluorescence with excitation/emission around 553/575 nm.
- Contains a four-unit polyethylene glycol spacer to increase hydrophilicity.
- Terminal carboxylic acid enables standard amide and ester coupling chemistries.
- High purity suitable for labeling, imaging, and analytical applications.
- Soluble in DMSO; ultrasonic treatment and formulation protocols improve aqueous compatibility.