Protein Modification Reagents
Medchemexpress LLC Amino-PEG4-GGFG-Dxd | 2879227-88-8 | MFCD09950912 | 100.0% | 1088.14 | C53H66FN9O15 | 1 MG
Amino-PEG4-GGFG-Dxd is a drug-linker conjugate designed for the synthesis of antibody-drug conjugates (ADCs). It consists of the DXd cytotoxic payload connected via a PEG4-GGFG peptide linker with a terminal amino group, and is supplied as an off-white to light yellow solid for research use only.
- Drug-linker conjugate intended for ADC synthesis.
- Contains DXd (an exatecan derivative) as the cytotoxic payload.
- PEG4-GGFG peptide linker provides spacer and protease-cleavable sequence.
- Terminal amino group enables conjugation to activated linkers or antibodies.
- High stated purity and solid form suitable for research applications.
Medchemexpress LLC Propargyl-PEG4-GGFG-DXd | 2762518-94-3 | MFCD01346226 | 100.0% | 1083.12 | C54H63FN8O15 | 10 MG
Propargyl-PEG4-GGFG-DXd is a pre-formed drug-linker conjugate intended for research use in antibody-drug conjugate (ADC) development. It combines a PEG4-linked GGFG tetrapeptide linker with a DXd topoisomerase I inhibitor payload to support linker evaluation and conjugation workflows.
- Contains a DXd topoisomerase I inhibitor payload.
- Includes a PEG4 spacer and GGFG tetrapeptide linker for conjugation.
- Off-white to light yellow solid, high purity suitable for analytical work.
- Soluble in DMSO at up to 100 mg/mL with ultrasonic assistance.
- Stable when stored sealed and protected from moisture; in solvent: -80 °C (6 months), -20 °C (1 month).
Medchemexpress LLC N3-PEG3-VC-PAB-MMAF | 2757277-32-8 | 100.0% | 1352.62 | C66H105N13O17 | 5 MG
N3-PEG3-VC-PAB-MMAF is an azide-functionalized antibody-drug conjugate (ADC) drug-linker conjugate combining a PEG3 spacer, a valine-citrulline cleavable linker with a p-aminobenzyl self-immolative spacer, and the tubulin inhibitor monomethyl auristatin F (MMAF). It is provided as a high-purity click-chemistry reagent for bioconjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition.
- Azide functional group enables CuAAC and SPAAC bioconjugation.
- Includes valine-citrulline-PAB cleavable linker for intracellular payload release.
- Contains monomethyl auristatin F as the cytotoxic payload.
- High purity suitable for research applications (>99.9%).
- Molecular weight 1352.62; formula C66H105N13O17.
- Recommended storage at -20°C under inert atmosphere; in solvent: -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC 2-amino-n-(14-azido-2,5-dioxo-9,12-dioxa-3,6-diazatetradecyl)acetamide | 2222277-20-3 | 95.0% | 345.35 g/mol | C12H23N7O5 | 1 ML
Gly-Gly-Gly-PEG2-azide is an azide-functionalized peptide-PEG linker supplied as a ready-to-use solution (10 mM in DMSO, 1 mL) or as a solid. It is intended for use in antibody-drug conjugate synthesis, bioconjugation, and related chemical biology applications.
- Azide-functionalized peptide-PEG2 linker for bioconjugation.
- Available as 10 mM solution in DMSO (1 mL) or solid forms.
- Used for antibody-drug conjugate synthesis and related chemistry.
- Characterized by CAS 2222277-20-3 and molecular weight 345.35 g/mol.
Medchemexpress LLC Propargyl-PEG4-GGFG-DXd | 2762518-94-3 | 100.0% | 1083.12 g/mol | C54H63FN8O15 | 50 MG
Propargyl-PEG4-GGFG-DXd is a drug-linker conjugate for antibody-drug conjugate (ADC) research that combines a cleavable GGFG-PEG4 linker with a propargyl reactive group and the DNA topoisomerase I inhibitor DXd as the payload. This compound is supplied for research use only and is intended for conjugation and ADC development studies.
- High stated purity suitable for research applications
- Contains a propargyl functional group for click chemistry conjugation
- Includes a cleavable GGFG linker designed for payload release
- Payload is a topoisomerase I inhibitor (DXd) for cytotoxic activity
- Available in multiple pack sizes for small-scale research
- Supplied for research use only, not for human use
eMolecules N-(Boc-PEG3)-N-bis(PEG2-alcohol) | 2055042-60-7 | MFCD30182039 | 500mg
Broadpharm | N-(Boc-PEG3)-N-bis(PEG2-alcohol) | 500mg | 309208953 | BP-23264 | 97.000 | 2055042-60-7 | MFCD30182039 | 556.694 | C25H52N2O11
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eMolecules Amino-PEG4-CH2CO2tBu | 864680-64-8 | MFCD28122943 | 1g
Broadpharm | Amino-PEG4-CH2CO2tBu | 1g | 254745387 | BP-22302 | 98.000 | 864680-64-8 | MFCD28122943 | 307.387 | C14H29NO6
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eMolecules Bis-Mal-Lysine-PEG4-TFP ester | 1426164-53-5 | MFCD28385461 | 1g
Broadpharm | Bis-Mal-Lysine-PEG4-TFP ester | 1g | 550804185 | BP-22617 | 98.000 | 1426164-53-5 | MFCD28385461 | 843.783 | C37H45F4N5O13
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eMolecules DNP-PEG12-NHS ester | 1334178-01-6 | MFCD13185013 | 1g
Broadpharm | DNP-PEG12-NHS ester | 1g | 550804147 | BP-22397 | 98.000 | 1334178-01-6 | MFCD13185013 | 880.895 | C37H60N4O20
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eMolecules DNP-PEG4-NHS ester | 858126-78-0 | MFCD13184987 | 1g
Broadpharm | DNP-PEG4-NHS ester | 1g | 550804146 | BP-22396 | 98.000 | 858126-78-0 | MFCD13184987 | 528.471 | C21H28N4O12
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Medchemexpress LLC Mal-amido-PEG2-C2-acid | 756525-98-1 | 99.8% | 328.32 | 5 G
Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are compounds that utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein via a linker.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins