Protein Modification Reagents
Medchemexpress LLC Mal-PEG4-vc-pab-dmea-pnu-159682 | 2259318-52-8 | 96.2% | 1559.62 | C74H98N10O27 | 25 MG
Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a cleavable drug-linker conjugate used for antibody-drug conjugate (ADC) research. It couples a maleimide-terminated PEG4 valine-citrulline (VC) self-immolative PAB linker to a potent cytotoxic payload to enable antibody conjugation and controlled release of the payload in target cells.
- Cleavable maleimide-PEG4 val-cit self-immolative linker enabling intracellular release.
- Includes a reactive maleimide moiety for thiol conjugation to antibodies.
- Supplied as a research-grade drug-linker conjugate for ADC development workflows.
- Provided with batch-specific certificate of analysis reporting HPLC purity and assay results.
- Soluble in common organic solvents such as DMSO for conjugation reactions.
Medchemexpress LLC N-Mal-N-bis(PEG4-NH-Boc) | 2128735-27-1 | 97.0% | C37H66N4O15 | 50 MG
N-Mal-N-bis(PEG4-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs
- PEG-based PROTAC linker
- Facilitates selective degradation of target proteins
- Utilizes the intracellular ubiquitin-proteasome system
Medchemexpress LLC Mal-amido-PEG8-TFP ester | 1924596-31-5 | C32H44F4N2O13 | 25 MG
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. This product leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Mal-PEG4-NHS ester | 1325208-25-0 | 99.4% | 442.42 | 50 MG
Mal-PEG4-NHS ester is a non-cleavable ADC linker. It is intended for research use only and not for sale to patients. This linker connects Quantum dots (QDs) with PEGylated liposomes.
- Non-cleavable linker
- Suitable for laboratory research
- High purity
- Multiple available sizes
eMolecules 1924596-31-5 | Mal-amido-PEG8-TFP ester | Broadpharm | MFCD28505514 | 740.699 | C32H44F4N2O13 | 98.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O)c1F | 1g | 550804213
Mal-amido-PEG8-TFP ester | Broadpharm | 1924596-31-5 | MFCD28505514 | 740.699 | C32H44F4N2O13 | 98.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O)c1F | 1g | 550804213
Medchemexpress LLC 1-Amino-N-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)-3,6,9,12-tetraoxapentadecan-15-amide HCl | 2656478-51-0 | 95.0% | 484.98 g/mol | C21H33ClN6O5 | 5 MG
Me-Tet-PEG4-NH2 hydrochloride is a methyltetrazine-functionalized PEG4 amine supplied as the hydrochloride salt. It is used as a click-chemistry reagent and linker for bioconjugation, enabling rapid inverse electron demand Diels-Alder (IEDDA) reactions with trans-cyclooctenes and facilitating PROTAC and antibody-drug conjugate assembly.
- Provides a methyltetrazine handle for fast IEDDA click reactions.
- Contains a primary amine for standard coupling chemistries.
- Incorporates a PEG4 spacer to improve aqueous solubility and reduce steric hindrance.
- Supplied as hydrochloride salt for enhanced stability and handling.
- Suitable for use in PROTAC and antibody-drug conjugate linker assembly.
- Typical purity ~95.0% by LCMS as reported on the certificate of analysis.
Aat Bioquest XFD532 PEG4 biotin conjugate, 1mg
The XFD532 PEG4 biotin conjugate incorporates the XFD532 fluorophore, which is structurally identical to Alexa Fluor 532 and efficiently excited at 532 nm. It exhibits strong orange fluorescence and high avidin-binding efficiency, closely resembling native biotin in affinity, rapid association, and non-cooperative binding to avidin and streptavidin tetramers. This conjugate is particularly well suited for the detection and quantification of biotin-binding sites on avidin, streptavidin, or neutravidin. In contrast to Biotin-4-fluorescein, which suffers from poor aqueous solubility, pH-dependent absorbance, and short-wavelength emission, the XFD532 PEG4 biotin conjugate is fully water soluble and maintains pH-independent fluorescence across the range of pH 4–10.
eMolecules 2144395-59-3 | DBCO-PEG5-NHS ester | Broadpharm | MFCD22380747 | 693.750 | C36H43N3O11 | 96.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)NCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 500mg | 462125598
DBCO-PEG5-NHS ester | Broadpharm | 2144395-59-3 | MFCD22380747 | 693.750 | C36H43N3O11 | 96.000 | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc12)NCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 500mg | 462125598
STA PHARMACEUTICAL US LLC Azide-PEG3-L-alanine-Fmoc | 1 g | CAS 2054345-69-4 | InChIKey YTHKPQSMRZQREU-JOCHJYFZSA-N
Azide-PEG3-L-alanine-Fmoc is a Amino Acid reagent (Subcategory: Azido/Alkynyl AA) sold by WuXi TIDES. Offered in 1 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 2054345-69-4
- MDL: No data
- InChIKey: YTHKPQSMRZQREU-JOCHJYFZSA-N
- Molecular Weight: 484.509
- Molecular Formula: C24H28N4O7
- Purity: ≥95%
- Container Type: 15 mL HDPE
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 7.8 g
- Commodity Code: 29299090
- Country Of Origin: China
- IUPAC: N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-D-serine
- SMILES: O=C(N[C@H](COCCOCCOCCN=[N+]=[N-])C(O)=O)OCC1C2=C(C=CC=C2)C3=C1C=CC=C3
TARGETMOL CHEMICALS INC DBCO-PEG4-Biotin 10MG
Also available in 1 mg, 5 mg and bulk. Please contact Fisher for quotes. DBCO-PEG4-Biotin (ADIBO-NH-PEG2-Biotin) is an azadibenzocyclooctyne-biotin derivative containing a biotin moiety and 4 PEGs.DBCO-PEG4-Biotin is a versatile biotinylation reagent that introduces a portion of biotin into an azide-labelled biomolecule via a copper-free catalytic alkyl azide reaction (SPAAC). azide-labelled biomolecules via a copper-free catalytic alkyl azide reaction (SPAAC). Purity 96.19%
Medchemexpress LLC Alkyne-PEG2-iodide | 1234387-33-7 | C7H11IO2 | 1 G
Alkyne-PEG2-iodide is a click chemistry reagent with terminal alkyne and alkyl iodide groups.
- Click chemistry reagent
- Features terminal alkyne groups
- Features alkyl iodide groups
- Targets ADC linker
- Pathway is antibody-drug conjugate/ADC related
Medchemexpress LLC DSPE-PEG-endo-BCN (MW 2000) | 93.3% | 2000 | 5 MG
DSPE-PEG-endo-BCN (MW 2000) is a PEG lipid designed to enhance the delivery efficiency and tissue specificity of poorly soluble drugs. It is suitable for use in drug delivery research.
- Peg lipid
- Can improve delivery efficiency of poorly soluble drugs
- Can improve tissue specificity of poorly soluble drugs
- Suitable for drug delivery research
eMolecules 2100306-73-6 | Benzyloxy carbonyl-PEG3-acid | Broadpharm | MFCD30723204 | 340.372 | C17H24O7 | 90.000 | OC(=O)CCOCCOCCOCCC(=O)OCc1ccccc1 | 500mg | 550804378
Benzyloxy carbonyl-PEG3-acid | Broadpharm | 2100306-73-6 | MFCD30723204 | 340.372 | C17H24O7 | 90.000 | OC(=O)CCOCCOCCOCCC(=O)OCc1ccccc1 | 500mg | 550804378
![eMolecules N-(Methyltetrazine-PEG4)-N-Biotin-PEG4-NHS | Broadpharm |1020.170 | C46H69N9O15S | 98.000 | Cc1nnc(nn1)-c1ccc(CC(=O)NCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(=O)CCCC[C@H]2SC[C@H]3NC(=O)N[C@@H]23)cc1 | 10mg | 724438927](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502479324.JPG-250.jpg)
eMolecules N-(Methyltetrazine-PEG4)-N-Biotin-PEG4-NHS | Broadpharm |1020.170 | C46H69N9O15S | 98.000 | Cc1nnc(nn1)-c1ccc(CC(=O)NCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(=O)CCCC[C@H]2SC[C@H]3NC(=O)N[C@@H]23)cc1 | 10mg | 724438927
N-(Methyltetrazine-PEG4)-N-Biotin-PEG4-NHS | Broadpharm |1020.170 | C46H69N9O15S | 98.000 | Cc1nnc(nn1)-c1ccc(CC(=O)NCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(=O)CCCC[C@H]2SC[C@H]3NC(=O)N[C@@H]23)cc1 | 10mg | 724438927
