Protein Modification Reagents

eMolecules​ 1807512-47-5 | Mal-PEG2-PFP | Broadpharm | MFCD26127799 | 423.292 | C17H14F5NO6 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCN2C(=O)C=CC2=O)c(F)c1F | 100mg | 229582671

Mal-PEG2-PFP | Broadpharm | 1807512-47-5 | MFCD26127799 | 423.292 | C17H14F5NO6 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCN2C(=O)C=CC2=O)c(F)c1F | 100mg | 229582671

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Medchemexpress LLC Propargyl-PEG4-NHS ester | 1428629-70-2 | MFCD22380743 | 97.0% | 357.36 g/mol | C16H23NO8 | 250 MG

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Propargyl-PEG4-NHS ester is a noncleavable four-unit polyethylene glycol (PEG) linker bearing a propargyl (alkyne) group and an N-hydroxysuccinimide (NHS) ester. It is used as a click chemistry reagent to couple azide-containing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC), and as a PEG-based linker in antibody-drug conjugate synthesis and other bioconjugation applications.

• Noncleavable four-unit PEG linker provides a hydrophilic spacer.
• Terminal propargyl (alkyne) group enables copper-catalyzed azide-alkyne click chemistry.
• NHS ester is amine-reactive for efficient conjugation to primary amines.
• High purity (97.0%) and molecular weight of 357.36 g/mol aid predictable performance.
• Viscous liquid form; recommended storage: pure form -20°C, in solvent -80°C or -20°C.

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Medchemexpress LLC Maytansine, N2'-deacetyl-N2'-[27-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-2,3-dimethyl | 2479378-44-2 | MFCD02066234 | 94.4% | 1297.92 | C68H89ClN6O17 | 1 MG

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DBCO-PEG4-Ahx-DM1 is a drug-linker conjugate that couples the cytotoxic maytansinoid DM1 to a DBCO-PEG4-Ahx clickable linker for use in antibody-drug conjugate development and conjugation chemistry.

• Intended for antibody-drug conjugate (ADC) construction.
• DBCO functional group enables copper-free click chemistry conjugation.
• PEG4-Ahx spacer provides flexibility and improved solubility.
• Contains DM1 maytansinoid as the cytotoxic payload.
• High purity (≈94.4%).
• Available in small research pack sizes and supplied as a solid.
• Storage: powder -20 °C (stable for 3 years); in solvent -80 °C for 6 months or -20 °C for 1 month.

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Medchemexpress LLC M-PEG-C1-DSPE sodium | 1000 | 1 G

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m-PEG-C1-DSPE sodium is a structural analog of m-PEG-DSPE sodium (HY-W440922). It is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. This product can be used in drug delivery research.

• Improve the delivery efficiency of poorly soluble drugs
• Improve the tissue specificity of poorly soluble drugs
• Suitable for drug delivery research

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Medchemexpress LLC Cl-C6-PEG4-O-CH2COOH | 1799506-30-1 | 98.0% | 370.87 | 1 G

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Cl-C6-PEG4-O-CH2COOH is a PEG-based PROTAC linker designed for the synthesis of chloroalkane-containing PROTACs (HaloPROTACs). This linker facilitates the formation of PROTACs, which are molecules that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• PEG-based PROTAC linker.
• Used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).
• Facilitates PROTACs with two ligands for E3 ubiquitin ligase and target protein.
• Exploits the intracellular ubiquitin-proteasome system.
• Selectively degrades target proteins.

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Medchemexpress LLC Mal-amido-PEG24-acid | 2171095-70-6 | 98.5% | C58H108N2O29 | 25 MG

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Mal-amido-PEG24-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. These molecules contain two different ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets a specific protein, leveraging the intracellular ubiquitin-proteasome system for selective protein degradation.

• Peg-based PROTAC linker
• Utilized in the synthesis of PROTACs
• Exploits the intracellular ubiquitin-proteasome system
• Enables selective degradation of target proteins
• Intended for research use only

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eMolecules​ Cy5-PEG5-NHBoc | BroadpharmMFCD28142459 | 881.590 | C49H73ClN4O8 | 96.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 10mg | 263744685

Cy5-PEG5-NHBoc | BroadpharmMFCD28142459 | 881.590 | C49H73ClN4O8 | 96.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 10mg | 263744685

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Medchemexpress LLC NH-bis(PEG4-C2-NH-Boc) | 2182601-75-6 | MFCD31536762 | ≥97.0% | C30H61N3O12 | 25 MG

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NH-bis(PEG4-C2-NH-Boc) is a colorless to light yellow liquid. This PEG-based PROTAC linker is used in the synthesis of PROTACs for research applications.

• Cas number: 2182601-75-6
• Chemical formula: C30H61N3O12
• Purity: ≥97.0%
• Appearance: Colorless to light yellow liquid
• For research use only

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eMolecules​ 2304558-23-2 | DBCO-PEG2-PFP ester | Broadpharm630.568 | C32H27F5N2O6 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(F)c1F | 100mg | 448298236

DBCO-PEG2-PFP ester | Broadpharm | 2304558-23-2630.568 | C32H27F5N2O6 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(F)c1F | 100mg | 448298236

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Medchemexpress LLC Bis-propargyl-PEG8 5mg | 1092554-87-4 | 5 MG

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Bis-propargyl-PEG8 is a PEG-based bifunctional linker with two terminal propargyl (alkyne) groups used as a click-chemistry reagent for bioconjugation and PROTAC synthesis.

• Contains two terminal propargyl (alkyne) groups for CuAAC reactions.
• Suitable for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
• PEG8 spacer provides hydrophilicity and flexible linkage.
• Molecular formula C22H38O9 and molecular weight 446.53 g·mol⁻¹.
• Available in small research quantities such as 5 MG.

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Medchemexpress LLC Dspe-peg 2000 | 892144-24-0 | >99.3% | (C2H4O)nC42H82NO10P | 100 MG

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DSPE-PEG 2000 is a PEG polymer that contains DSPE and amine end groups. It can be utilized to form micelles, which function as nanoparticles for drug delivery.

• Application: Can be used to form micelles as nanoparticles for drug delivery.
• Appearance: Solid, white to off-white.
• Solubility: In DMSO: 50 mg/mL (requires ultrasonic; note that hygroscopic DMSO significantly impacts solubility, so use newly opened DMSO). In ethanol: 25 mg/mL (requires ultrasonic, warming, and heating to 60°C). In H2O: 25 mg/mL (requires ultrasonic, warming, and heating to 60°C).
• Storage: Powder: -20°C for 3 years. In solvent: -80°C for 6 months, -20°C for 1 month.

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Medchemexpress LLC Ald-Ph-amido-PEG4-C2-NHS ester | 1353011-74-1 | MFCD20926371 | 98.1% | 494.49 | C23H30N2O10 | 1 G

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Ald-Ph-amido-PEG4-C2-NHS ester is a noncleavable 4-unit polyethylene glycol (PEG4) NHS ester linker used for antibody-agent conjugation research. It provides an activated N-hydroxysuccinimide (NHS) ester for amine coupling and an aldehyde-phenyl (Ald-Ph) moiety with a two-carbon spacer, suitable for bioconjugation and linker synthesis. Supplied at high reported purity and available in multiple pack sizes.

• Noncleavable 4-unit PEG linker for antibody-agent conjugation.
• Activated NHS ester for efficient amine coupling.
• Aldehyde-phenyl functional group with a C2 spacer.
• Molecular weight 494.49 g/mol.
• Purity approximately 98.1% as reported.
• Available in multiple pack sizes, including 1 G.

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eMolecules​ 1334177-86-4 | Mal-amido-PEG8-acid | Broadpharm | MFCD13184956 | 592.639 | C26H44N2O13 | 97.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 100mg | 249969292

Mal-amido-PEG8-acid | Broadpharm | 1334177-86-4 | MFCD13184956 | 592.639 | C26H44N2O13 | 97.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 100mg | 249969292

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Cayman Chemical VH 032 LInker 3hydrate 1mg

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A derivative of VHL ligand 1

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eMolecules​ 1603854-42-7 | Biotin-PEG4-Amide | Broadpharm490.620 | C21H38N4O7S | 95.000 | NC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 50mg | 573896512

Biotin-PEG4-Amide | Broadpharm | 1603854-42-7490.620 | C21H38N4O7S | 95.000 | NC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 50mg | 573896512

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