Protein Modification Reagents
Medchemexpress LLC Azide-PEG2-Ms | 176520-23-3 | ≥97.0% | C5H11N3O4S | 250 MG
Azide-PEG2-Ms is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules possessing Alkyne groups. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker.
- Can be used in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains an azide group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
Medchemexpress LLC m-PEG4-CH2-methyl ester | 1920109-55-2 | MFCD26318564 | >98% | C12H24O6 | 25 MG
m-PEG4-CH2-methyl ester is a PROTAC linker that is based on PEG and Alkyl/ester. It can be utilized in the synthesis of PROTACs. PROTACs are designed with two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. These molecules function by harnessing the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG- and Alkyl/ester-based PROTAC linker.
- Used in the synthesis of PROTACs.
- PROTACs selectively degrade target proteins by exploiting the ubiquitin-proteasome system.
Medchemexpress LLC Azide-PEG-amine | 95.0% | 25 MG
Azide-PEG-amine (MW 2000) is a PEG-based PROTAC linker, essential for synthesizing PROTACs. It acts as a versatile click chemistry reagent, featuring an azide group. This enables its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. PROTACs utilize this linker to connect ligands, targeting E3 ubiquitin ligase and a protein of interest for selective degradation. This product is for research use only.
- PEG-based PROTAC linker for PROTAC synthesis
- Functions as a click chemistry reagent with an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Supports strain-promoted alkyne-azide cycloaddition (SPAAC)
- Leverages ubiquitin-proteasome system for selective protein degradation
- Intended for research use only
Medchemexpress LLC DSPE-PEG carboxylic acid (sodium) | 1403744-37-5 | 98.0% | (C2H4O)nC45H86NO12P.Na | 25 MG
DSPE-PEG Carboxylic acid (sodium), MW 2000 is a PEG-lipid that can be used in the preparation of drug delivery nanoparticles. It is capable of extending the blood circulation time and stability of liposomes, while also improving the targeting ability and cellular uptake efficiency of nanoparticles.
- Used in the preparation of drug delivery nanoparticles
- Prolongs the blood circulation time and stability of liposomes
- Enhances the targeting ability of nanoparticles
- Improves cellular uptake efficiency of nanoparticles
Medchemexpress LLC Methyltetrazine-PEG4-maleimide | 1802908-02-6 | 98.6% | C24H30N6O7 | 25 MG
Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent containing a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a Tetrazine group
- Undergoes inverse electron demand Diels-Alder reaction (iEDDA) with TCO groups
Medchemexpress LLC N-DBCO-N-bis(PEG2-C2-acid) | 2110449-00-6 | 96.7% | C33H40N2O10 | 25 MG
N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing Azide groups. PROTACs comprise two distinct ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, facilitating the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- Peg-based protac linker
- Click chemistry reagent
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables selective degradation of target proteins
Medchemexpress LLC Hydroxylamine, O,O'-(3,6,9,12-tetraoxatetradecane-1,14-diyl)bis- | 98627-72-6 | 96.0% | C10H24N2O6 | 250 MG
Bis-aminooxy-PEG4 is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTACs consist of two distinct ligands joined by a linker, one targeting an E3 ubiquitin ligase and the other for a specific target protein. This mechanism leverages the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC DNP-PEG4-NHS ester | 858126-78-0 | 96.8% | C21H28N4O12 | 250 MG
DNP-PEG4-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins, functioning through two ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other binding to the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system to degrade target proteins
- Viscous liquid appearance
- Light yellow to green yellow color
- Soluble in DMSO (≥ 100 mg/mL)
- Insoluble in H2O (< 0.1 mg/mL)
Medchemexpress LLC Methyltetrazine-PEG5-NHS ester | 1802907-92-1 | MFCD28122951 | 97.0% | C24H31N5O9 | 250 MG
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, and the other to the target protein. This mechanism exploits the intracellular ubiquitin-proteasome system for selective degradation of target proteins. It is intended for research use only.
- PEG-based PROTAC linker
- Used in synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Solid appearance, purple to purplish red color
- Solubility in DMSO: 100 mg/mL
- Powder storage: -20°C for 3 years
- For research use only
Medchemexpress LLC Boc-N-Amido-PEG4-propargyl | 1219810-90-8 | 99.7% | C16H29NO6 | 250 MG
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing an Alkyne group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs themselves are designed with two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets the protein of interest, utilizing the intracellular ubiquitin-proteasome system for selective protein degradation.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Tos-PEG5-CH2COOtBu | 1949793-62-7 | C23H38O10S | 250 MG
Tos-PEG5-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is associated with applications in cancer-programmed cell death, and its target is PROTAC Linkers.
- Used in the synthesis of PROTACs.
- Associated with applications in cancer-programmed cell death.
- Target is PROTAC linkers.
Medchemexpress LLC Biotin-PEG4-TFP ester | 2985664-57-9 | 97.8% | C27H37F4N3O8S | 25 MG
Biotin-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein. This linker exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- For research use only
Medchemexpress LLC Biotin-PEG4-azide | 1309649-57-7 | 99.8% | C20H36N6O6S | 25 MG
Biotin-PEG4-azide is a biotin-labeled, PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It functions as a versatile click chemistry reagent, facilitating both copper-catalyzed and strain-promoted cycloaddition reactions.
- Biotin-labeled and PEG-based PROTAC linker
- Essential for PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups
- Supports strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
Medchemexpress LLC DSPE-PEG-COOH | No CAS number listed for this product (HY-W591461). | No MFCD number listed for this product (HY-W591461). | 100.0% | 2000 (average) | No chemical formula listed for this product (polymeric PEG; variable repeat unit). | 25 MG
DSPE-PEG-COOH, MW 2000 is a PEGylated phospholipid used to formulate liposomes and lipid nanoparticles. It is supplied as a white to off-white solid and features a terminal carboxylic acid that can be activated to form stable amide bonds with primary amines for surface conjugation. Typical storage is -20°C, sealed, away from moisture.
- Terminal carboxylic acid for amide bond conjugation.
- Suitable for liposome and lipid nanoparticle formulation.
- White to off-white solid for easy handling and weighing.
- Available in small research pack sizes for lab use.
- High purity suitable for research use (purity ≥99.9%).
Medchemexpress LLC Methyltetrazine-PEG5-NHS ester | 1802907-92-1 | 97.0% | C24H31N5O9 | 50 MG
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This product is for research use only.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Purity of 97.0%