Protein Modification Reagents
Medchemexpress LLC Dbco-PEG5-NHS ester | 2144395-59-3 | 693.74 g/mol | C36H43N3O11 | 50 MG
Dbco-PEG5-NHS ester is a heterobifunctional, PEG-based bioorthogonal linker that combines a dibenzocyclooctyne (DBCO) moiety for strain-promoted alkyne-azide cycloaddition with an N-hydroxysuccinimide (NHS) ester for selective coupling to primary amines. It is intended for use in bioconjugation workflows such as antibody-drug conjugate and PROTAC synthesis, and for copper-free click chemistry and surface labeling.
- Enables copper-free click conjugation to azide-containing molecules via the DBCO group.
- Allows rapid amine coupling through the NHS ester at pH 7-9.
- PEG5 spacer improves solubility and reduces steric hindrance.
- Supplied as a small-scale reagent suitable for research and development work.
Medchemexpress LLC Azide-PEG4-VC-PAB-doxorubicin | 99.6% | 1222.25 | C57H75N9O21 | 25 MG
Azide-PEG4-VC-PAB-doxorubicin is an azide-functionalized PEG4 val-cit-PAB linker conjugated to doxorubicin used to prepare antibody-drug conjugates and for click-chemistry applications.
- Contains an azide group for copper-catalyzed and strain-promoted azide-alkyne cycloaddition reactions.
- Includes a protease-cleavable Val-Cit-PAB linker for intracellular payload release.
- Contains doxorubicin as the cytotoxic payload (anthracycline class).
- High listed purity suitable for research (soluble in DMSO at 100 mg/mL).
- Store as a solid at recommended low temperatures for long-term stability.
Medchemexpress LLC CY7-N3 (Sulfo-Cyanine7-N3) | 97.6% | 763.95 | 5 MG
CY7-N3 (Sulfo-Cyanine7-N3) is a water-soluble Near-Infrared (NIR) dye azide designed for Click Chemistry. It possesses an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
- Water-soluble NIR dye azide
- Contains an azide group for Click Chemistry
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC)
Medchemexpress LLC (S,R,S)-AHPC-PEG5-Boc | 2923734-82-9 | 95.3% | C40H62N4O11S | 10MG
(S,R,S)-AHPC-PEG5-Boc is an E3 ligase ligand-linker conjugate that couples an (S,R,S)-AHPC-based VHL ligand to a PEG5 linker with a Boc protecting group. Supplied as a solid research reagent, it is intended for use as the ligand-linker component in PROTACs such as Cdc20-targeting degraders.
- Incorporates the (S,R,S)-AHPC VHL ligand
- Contains a PEG5 linker with Boc protection
- Provided as a solid, light yellow to yellow material
- Molecular formula: C40H62N4O11S
- Molecular weight: 807.01 g·mol⁻¹
- Reported purity: 95.3%
- Storage: -20 °C under nitrogen; in solvent -80 °C (6 months) or -20 °C (1 month)
- Available in milligram to gram sizes for research use
Cayman Chemical GefItInIb-based PROTAC 3 25mg
A PROTAC comprised of gefitinib linked to VHL ligand 1; induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion (DC50s = 22.3 and 11.7 nM, respectively) but does not induce degradation of wild-type EGFR at ≤10 μM in cell-based assays
Medchemexpress LLC Tos-peg4-nh-boc (PROTAC linker 7) | 1246999-33-6 | ≥98.0% | 1 G
Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase, and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Consists of two different ligands connected by a linker
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Bromoacetamido-PEG4-C2-Boc | 1807521-00-1 | 1 G
Bromoacetamido-PEG4-C2-Boc is a laboratory chemical used for the manufacture of substances. It is stable under recommended storage conditions.
- Harmful if swallowed
- Causes skin and serious eye irritation
- May cause respiratory irritation
- Store in a cool, well-ventilated area away from direct sunlight and ignition sources
- Recommended storage for pure form: -20°C for 3 years or 4°C for 2 years
- Recommended storage for in solvent: -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC N-hydroxysuccinimide-activated PEG4-Val-Cit-PAB-MMAE | 2762518-86-3 | MFCD09835251 | 98.9% | 1496.78 | C74H117N11O21 | 5 MG
OSu-PEG4-VC-PAB-MMAE is an N-hydroxysuccinimide (OSu) activated PEG4 val-cit-para-aminobenzyl (PAB) linker conjugated to monomethylauristatin E (MMAE). It is supplied as a white to off-white solid for research use in antibody-drug conjugate synthesis and site-specific conjugation.
- Suitable for site-specific conjugation in ADC construction.
- Contains a cleavable val-cit linker and self-immolative PAB spacer.
- Provided as a high-purity solid, facilitating storage and handling.
- Stable when stored at -80°C and protected from light under inert atmosphere.
- Soluble in common organic solvents and DMSO for reaction preparation.
![eMolecules Broadpharm / TCO-PEG2-acid / 25mg / 698443002 / BP-27908 / 98.000 / 2250217-31-1 / [null] / 329.393 / C16H27NO6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502494084.JPG-250.jpg)
eMolecules Broadpharm / TCO-PEG2-acid / 25mg / 698443002 / BP-27908 / 98.000 / 2250217-31-1 / [null] / 329.393 / C16H27NO6
Broadpharm / TCO-PEG2-acid / 25mg / 698443002 / BP-27908 / 98.000 / 2250217-31-1 / [null] / 329.393 / C16H27NO6
eMolecules N-(PEG1-OH)-N-Boc-PEG2-propargyl | 2100306-85-0 | MFCD30730381 | 500mg
Broadpharm | N-(PEG1-OH)-N-Boc-PEG2-propargyl | 500mg | 347153866 | BP-23611 | 98.000 | 2100306-85-0 | MFCD30730381 | 331.409 | C16H29NO6
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eMolecules Building Block Tool
Medchemexpress LLC 4-Arm PEG-SCM MW 10 1g
4-Arm PEG-SCM (MW 10000) is a multi-arm PEG derivative that can be used for peptide modification and drug delivery[1]
![eMolecules Broadpharm / Diazo Biotin-PEG3-DBCO / 5mg / 510428471 / BP-22452 / 95.000 / / [null] / 973.160 / C52H60N8O9S](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502512619.JPG-250.jpg)
eMolecules Broadpharm / Diazo Biotin-PEG3-DBCO / 5mg / 510428471 / BP-22452 / 95.000 / / [null] / 973.160 / C52H60N8O9S
Broadpharm / Diazo Biotin-PEG3-DBCO / 5mg / 510428471 / BP-22452 / 95.000 / / [null] / 973.160 / C52H60N8O9S
Grainger Open End Peg Rack 19.88 L Blue PK6
The Carlisle Open End Peg Rack is a 19-7/8" long metal peg rack with 12 pegs for hanging tools, parts, and other items. It has a durable steel construction with a gray powder coat finish and can hold up to 25 pounds per peg. The pegs have rounded ends and are 1" in diameter, spaced 2" apart. This versatile peg rack can be mounted to walls or workbenches using the included mounting hardware. With its heavy-duty build, it's ideal for workshops, garages, utility rooms, and other storage areas to keep essentials within reach but organized.
Nanocs DBCO PEG Folic acid, 2k Da. 5mg
DBCO PEG Folic acid, also called DBCO PEG folate, is one of Nanocs' folic acid PEG derivatives that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG folate derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. Folic acid, is also known as vitamin M, vitamin B9 or pteroyl-L-glutamic acid. Folic acid is an essential bioactive molecule for numerous biological functions. It participates in the synthesis, repairing and methylation of DNA as well as to act as a cofactor in many biological reactions. DBCO functional folic acid can be easily attached to azide functionalized molecules, particles or solid surfaces.
