Protein Modification Reagents

eMolecules​ Broadpharm Fmoc-N-amido-PEG4-acid 500mg 208940413 BP-20989 98 000 557756-85-1 MFCD06656472 487 549 C26H33NO8

Broadpharm Fmoc-N-amido-PEG4-acid 500mg 208940413 BP-20989 98 000 557756-85-1 MFCD06656472 487 549 C26H33NO8

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Medchemexpress LLC Hs-peg6-ch2ch2-boc | 1818294-40-4 | MFCD26127815 | 95.0% | 426.57 g/mol | C19H38O8S | 5 MG

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HS-PEG6-CH2CH2-Boc is a PEG-based linker bearing a thiol terminus and a Boc-protected terminus, designed for use in the synthesis of PROTACs and other bifunctional molecules. It provides a flexible, hydrophilic spacer useful for connecting ligands while maintaining solubility and synthetic handle orthogonality.

• Suitable for use in PROTAC and bifunctional molecule synthesis.
• Thiol terminus enables selective conjugation to thiol-reactive partners.
• PEG6 spacer provides flexibility and improved aqueous solubility.
• Boc-protected terminus allows orthogonal protection and selective deprotection.
• Molecular formula C19H38O8S; molecular weight 426.57 g/mol.

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Medchemexpress LLC N3-PEG3-VC-PAB-MMAF | 2757277-32-8 | 100.0% | 1352.62 | C66H105N13O17 | 25 MG

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N3-PEG3-VC-PAB-MMAF is a drug-linker conjugate for antibody-drug conjugate (ADC) research that combines an azide-functionalized PEG3 spacer, a valine-citrulline (VC) cleavable linker with a para-aminobenzyl (PAB) self-immolative spacer, and the tubulin inhibitor MMAF to enable click chemistry conjugation and controlled payload release.

• Azide-functionalized PEG3 spacer for click chemistry conjugation.
• VC-PAB cleavable linker enabling enzymatic release of payload.
• Includes MMAF payload for tubulin inhibition in ADC constructs.
• White to off-white solid with high purity suitable for research use.
• Available in small milligram pack sizes for synthesis workflows.

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Medchemexpress LLC TCO-PEG4-VC-PAB-MMAE | 2758671-45-1 | 99.3% | 1522.91 | C78H127N11O19 | 10 MG

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TCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate intended for use in antibody-drug conjugate (ADC) assembly and click-chemistry bioconjugation workflows. It combines a trans-cyclooctene (TCO) click handle, a PEG4-Val-Cit-PAB cleavable linker, and the cytotoxic payload MMAE to enable site-selective conjugation and intracellular release of the payload.

• Provides a trans-cyclooctene (TCO) handle for inverse electron-demand Diels-Alder reactions with tetrazines.
• Contains a PEG4-Val-Cit-PAB cleavable linker for enzymatic payload release.
• Conjugated to MMAE to supply a potent cytotoxic payload for ADC research.
• High purity (99.3%) suitable for research and bioconjugation workflows.
• Characterized by molecular weight 1522.91 and formula C78H127N11O19.

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eMolecules​ Broadpharm / 14-(Amine-PEG3-ethylcarbamoyl)tridecanoic t-butyl ester / 100mg / 784455746 / BP-40052 / 95.000 / / [null] / 488.710 / C26H52N2O6

Broadpharm / 14-(Amine-PEG3-ethylcarbamoyl)tridecanoic t-butyl ester / 100mg / 784455746 / BP-40052 / 95.000 / / [null] / 488.710 / C26H52N2O6

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Medchemexpress LLC Diketone-PEG4-biotin | 2353409-85-3 | 95.0% | C33H50N4O9S | 10MG

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Diketone-PEG4-Biotin is a PEG-based PROTAC linker bearing a biotin affinity tag for use in chemical biology and targeted protein degradation research. It provides a flexible, water-soluble spacer to enable conjugation and affinity capture in the synthesis of bifunctional molecules and assay workflows.

• Peg-based linker with biotin for affinity capture.
• Compatible with PROTAC synthesis and bifunctional conjugates.
• Provides a flexible spacer to reduce steric hindrance.
• Facilitates pull-down assays and target engagement studies.
• Supplied with specified purity for research applications.
• Available in small research pack sizes for method development.

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eMolecules​ Broadpharm / DSPE-PEG-Boronate MW 3400 / 100mg / 718091659 / BP-28212 / 90.000 / / [null] / 1045.130 / C53H95BFN2O14P

Broadpharm / DSPE-PEG-Boronate MW 3400 / 100mg / 718091659 / BP-28212 / 90.000 / / [null] / 1045.130 / C53H95BFN2O14P

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eMolecules​ Bromoacetamido-PEG5-Propargyl | 1807521-10-3 | MFCD28064329 | 500mg

Broadpharm | Bromoacetamido-PEG5-Propargyl | 500mg | 550804089 | BP-22203 | 98.000 | 1807521-10-3 | MFCD28064329 | 396.278 | C15H26BrNO6

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Medchemexpress LLC DBCO-PEG4-DBCO | 2182601-68-7 | 97.4% | 810.93 | C48H50N4O8 | 10 MG

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DBCO-PEG4-DBCO is a PEG-based bifunctional linker bearing two dibenzocyclooctyne (DBCO) groups. It is used as a click chemistry reagent for strain-promoted alkyne-azide cycloaddition (SPAAC) and as a PEG linker in PROTAC and antibody-drug conjugate (ADC) synthesis.

• Click chemistry reagent enabling SPAAC with azide-functionalized partners.
• Provides a PEG4 spacer to improve solubility and linker flexibility.
• High solubility in DMSO; manufacturer provides in vitro and in vivo formulation protocols.
• Typical purity around 97.4% and appears as a white to yellow solid.
• Suitable for use in PROTAC and ADC synthesis workflows.

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Cayman Chemical STng PROTAC SP23 1mg

A PROTAC that drives STING degradation; degrades STING in THP-1 cells (DC50 = 3.2 µM); decreases cGAMP-induced increases in the levels of IFN-β, IL-6, and CXCL10 in THP-1 cells at 2.5-10 µM; reduces kidney weight, improves kidney function, and increases the survival rate in a mouse model of cisplatin-induced acute kidney injury at 30 and 60 mg/kg

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eMolecules​ Broadpharm / (S)-26-Bis-(m-PEG8)-amidohexanoic acid / 100mg / 445408939 / BP-24221 / / 2353409-77-3 / [null] / 967.110 / C42H82N2O22

Broadpharm / (S)-26-Bis-(m-PEG8)-amidohexanoic acid / 100mg / 445408939 / BP-24221 / / 2353409-77-3 / [null] / 967.110 / C42H82N2O22

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eMolecules​ Broadpharm / DSPE-Amide-PEG-Rhodamine MW 2000 / 5mg / 795361903 / BP-40234 / / / [null] / 1376.220 / C75H121ClN4NaO13P

Broadpharm / DSPE-Amide-PEG-Rhodamine MW 2000 / 5mg / 795361903 / BP-40234 / / / [null] / 1376.220 / C75H121ClN4NaO13P

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Medchemexpress LLC DSPE-Mal | 1360858-99-6 | 95.0% | 899.18 g/mol | C48H87N2O11P | 50 MG

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DSPE-Mal is a maleimide-functional phospholipid used to introduce thiol-reactive maleimide groups into lipid assemblies and liposomes, enabling covalent coupling of thiol-containing ligands for targeted nanocarrier and surface functionalization applications.

• Maleimide-functionalized phospholipid for thiol-specific conjugation.
• Facilitates stable covalent coupling of thiol-containing ligands to lipid bilayers.
• Amphiphilic structure supports self-assembly into liposomes and vesicles.
• Useful for targeted drug delivery and nanocarrier surface modification.
• Offered in small research-scale quantities for formulation studies.

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Medchemexpress LLC Pomalidomide-PEG4-C-COOH | 2097938-44-6 | MFCD31540390 | 99.2% | 507.49 g·mol⁻¹ | C23H29N3O10 | 10 MG

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Pomalidomide-PEG4-C-COOH is an E3 ligase ligand-linker conjugate that combines a pomalidomide-derived cereblon ligand with a four-unit polyethylene glycol (PEG4) spacer terminating in a carboxylic acid. It is intended for use in targeted protein degradation research and PROTAC design, providing a conjugation handle and improved linker flexibility and solubility.

• Contains pomalidomide-based cereblon ligand.
• Four-unit PEG linker provides flexibility and solubility.
• Terminal carboxylic acid enables conjugation to target ligands.
• Designed for PROTAC design and chemical biology applications.
• High purity (99.19% by LCMS).
• Molecular weight 507.49 g·mol⁻¹; formula C23H29N3O10.
• Available in small research quantities suitable for assay development.

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Medchemexpress LLC 3,6,9,12-tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate) | 875770-32-4 | 99.3% | 386.46 | C18H26O7S | 250 MG

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Propargyl-PEG4-Tos is a PEG-based linker used as an alkyne click-chemistry reagent and cleavable linker for PROTAC and antibody-drug conjugate synthesis. It provides a hydrophilic PEG4 spacer to improve solubility and enable CuAAC functionalization.

• Click chemistry alkyne for copper-catalyzed azide-alkyne cycloaddition
• Cleavable ADC and PROTAC linker functionality
• PEG4 spacer increases hydrophilicity and solubility
• Confirmed identity by 1H NMR and LCMS
• High purity (HPLC 99.3%)

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