Immunohistochemistry Kits and Reagents
Biotium Cytokeratin 8(B22.1), CF740 conjugate, 0.1mg/mL
Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant)
American Research Products Inc PrEST Antigen IGF2BP1
PrEST Antigen IGF2BP1 antigen APrEST87959 for insulin-like growth factor 2 mRNA binding protein 1 Recombinant protein fragment of Human IGF2BP1
Abcam 2 mm Coronal Mouse Brain Slicer, 1UNIT
This 2 mm coronal mouse brain slicer allows you to easily cut a brain into smaller pieces for easier imaging with objectives that have a limited working distance.
The product is subject to the following: Abcam Restricted Use Statement
VITRO VIVO BIOTECH LLC COX-SDH DOUBLE HISTOCHEMISTRY
VitroView™ COX-SDH Double Histochemistry Stain Kit (For 50-100 Slides).
Biotium CD25(IL2RA/423), CF594 conjugate, 0.1mg/mL
Recognizes a protein of 55 kDa, identified as CD25. It is expressed on activated T- and B-cells and activated monocytes/macrophages. With respect to lymphomas, CD25 is present on malignant cells of Hodgkin's disease, HTLV-1 adult T-cell leukemia, cutaneous T-cell lymphoma, and hair cell leukemia. Increased levels of soluble CD25 are observed in the leukemias/lymphomas and inflammatory/ autoimmune diseases. CD25 molecule alone appears to function as a low affinity receptor and associates with CD122 (IL-2R beta chain, p75) and CD132 (common gamma chain) to form the high affinity IL-2 receptor complex. CD25 antibodies detect three epitope regions, A, B and C. This MAb recognizes the epitope B, which is located at residue 3-104 of CD25 and doe not block IL-2 binding to CD25.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes l
Invivogen Purified Lipoteichoic acid from S. aureus (LTA-SA), 5mg
Specificity: TLR2 agonist, Working concentration: 1 ng -1 μg/ml, Endotoxin level: EndoFit™, Lipoteichoic acid (LTA) is a major immunostimulatory component of Gram-positive bacteria. Like LPS, LTA is an amphiphile formed by a hydrophilic polyphosphate polymer linked to a neutral glycolipid. LTA stimulates immune cells through TLR2 to produce TNF-α and other inflammatory cytokines. Recognition of LTA involves also LPS-binding protein (LBP) and CD14.
Biocare Medical, LLC Aqua DePar, 10X
Aqua DePar is a water-soluable deparaffinization reagent which can be used for immunohistochemistry, H&E and special stains. Aqua DePar is non-flammable and safe to use. Paraffin is completely broken down and dissolved by Aqua DePar. This product eliminates the use of xylenes, xylene substitutes and alcohols, thus saving money and reducing toxic waste, hazardous and flammable materials, and exposure to child-bearing women. Hundreds of tissues and several different kinds of paraffin were tested for H&E, special stains and immunohistochemistry. A direct comparison was made with traditional xylene methods. No differences with Aqua DePar were noted between the two methods, except nuclear detail was more crisp and sharp with H&E staining with Aqua DePar compared to the traditional xylene method.
HORIZON DISCOVERY BIOSCIENCES LIMITED Quantitative Multiplex Reference Standard (FFPE)
The Quantitative Multiplex FFPE Reference Standard is a highly-characterized, biologically-relevant quality control material used to assess the performance of NGS assays that detect somatic mutations.
Biotium c-Myc(MYC275), CF594 conjugate, 0.1mg/mL
The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability.
Medchemexpress LLC Pemafibrate Ready For Reconst | HY-17618-10MM-1ML DMSO
Pemafibrate Ready For Reconst
Cayman Chemical S-p38 MAPK InhIbItr III 10mg
A methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 µM in vitro); potently blocks the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 µM, respectively)
Roche Diagnostics Discovery Green HRP Kit, chromogen detection kit, green signal, 50 tests
Discovery Green HRP Kit, chromogen detection kit, green signal, 50 tests
Biocare Medical, LLC MACH 2 Double Stain 2 - 100 ml
The conjugated goat anti-mouse polymer horseradish peroxidase (HRP) and the conjugated goat anti-rabbit polymer alkaline phosphatase (AP) secondary antibodies react with both heavy and light chains on mouse and rabbit IgG respectively. This innovative HRP- and AP-polymerization technology provides a significant increase in staining sensitivity when compared to other conventional HRP- or AP-conjugated secondary antibodies. Avidin-biotin blocking procedures are not necessary when using the MACH 2 conjugated secondary antibodies. It is specially designed for a rapid double stain procedure. An antibody cocktail with a mouse monoclonal and a rabbit polyclonal/monoclonal must be used. The overall staining procedure can be done with 4 major steps and in less than two hours. It can be used manually or used with automated stainers.
Abcam DoubleStain IHC Kit: G&Rt on human/mouse tissue (BCIP & AEC), 60ML
The DoubleStain IHC kit (ab183281) is designed to be used with user supplied goat and rat primary antibodies to detect two distinct antigens on human or mouse tissue or cell samples.
The product is subject to the following: Abcam Restricted Use Statement