Cardiotoxin Analog (CTX) IV (6-12) is a membrane-active peptide that specifically targets negatively charged phospholipid membranes, such as phosphatidylserine and phosphatidylinositol, and and can be isolated from the venom of the Taiwan cobra. It is a snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of the membrane structure. This analog can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity.
- Targets negatively charged phospholipid membranes
- Isolated from Taiwan cobra venom
- Binds to cell membranes
- Induces membrane lipid disorder and cell lysis
- Exhibits hemolysis and cytotoxicity