Protein Purification
Cayman Chemical sPLA2 InhIbItr 10mg
An orally active inhibitor of sPLA2-IIA; protects against intestinal reperfusion injury in rats when given at 10 mg/kg orally; attenuates NF-κB signaling in lung cancer cells and protects against diet-induced metabolic syndrome in rats
Medchemexpress LLC FGFR1/DDR2 inhibitor 10mM 1mL | 2308497-58-5 | 1 ML
FGFR1/DDR2 inhibitor 1 is a small-molecule kinase inhibitor used in preclinical research to inhibit FGFR1 and DDR2. It is supplied as a 10 mM solution in DMSO or as solid quantities for biochemical and cellular assays.
- Potent inhibition of FGFR1 and DDR2
- High purity (98.26%)
- Molecular weight 501.50 g/mol
- Available as 10 mM solution in DMSO or in solid quantities
- Suitable for kinase assays and target validation studies
- Store powder and solutions under recommended conditions to maintain stability
Cayman Chemical Cdk1 InhIbItr 1mg
An inhibitor of Cdk1 (IC50 = 5.8 µM); selective for Cdk1 over Cdk5 and GSK3β (IC50s = 25 and >100 µM, respectively); inhibits HeLa cell proliferation (IC50 = 2 µM)
Cayman Chemical Syk InhIbItr II 5mg
A cell-permeable, selective, and reversible inhibitor of Syk (IC50 = 41 nM); prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and inhibits passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.)
Cayman Chemical Mps1tK InhIbItr 25mg
An inhibitor of Mps1/TTK (IC50 = 5.8 nM); inhibits Mps1 phosphorylation of KNL1 and increases the rate of mitosis at 100 nM; increases the number of missegregated chromosomes at 50 and 100 nM; inhibits colony formation of DLD1, HCT116, and U2OS cells (IC50s = 24.6, 20.1, and 20.6 nM, respectively)
TARGETMOL CHEMICALS INC PEPSTATIN 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Pepstatin (Pepsin Inhibitor S 735A) is a specific aspartic proteases inhibitor produced by actinomycetes and inhibits the aspartic proteases cathepsin D pepsin and renin. purity: 99%
CPC Scientific MCA-Val-Asp-Gln-Val-Asp-Gly-Trp-Lys(DNP)-NH2 (trifluoroacetate salt) 0.5MG
Fluorogenic resonance energy transfer substrate used for the detection of caspase-7 activity.SEQUENCE: MCA-Val-Asp-Gln-Val-Asp-Gly-Trp-Lys(DNP)-NH2 (trifluoroacetate salt)ONE-LETTER SEQUENCE: Mca-VDQVDGW-Lys(Dnp)-NH2MOLECULAR FORMULA: C60H74N14O21MOLECULAR WEIGHT: 1327.3STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: SYNONYMS: RESEARCH AREA: ApoptosisREFERENCES:SKU(s): CASP-028A, CASP-028B
Cayman Chemical FOXM1 InhIbItr III 5mg
An inhibitor of FOXM1 DNA-binding activity (IC50 = 22.5 µM); binds to FOXM1 and is selective for inhibiting FOXM1 transcriptional activity over FOXA1, FOXA2, FOXP2, and GATA-1 transcriptional activity; inhibits the growth of MCF-7, MDA-MB-231, and PEO1 cancer cells (GI50s = 18, 21.8, and 18.1 µM, respectively)
Biotang Inc Protease Inhibitors Cocktail for Mammalian Cells, 1 ml
Protease Inhibitors Cocktail for Mammalian Cells, 1 ml.
Cayman Chemical PD-1PD-L1 InhIbItr N11 1mg
A PD-1/PD-L1 interaction inhibitor (IC50 = 6.3 nM); increases T cell proliferation in a PD-L1-overexpressing CT26 colon cancer cell and T cell co-culture at 20 nM; promotes T cell infiltration into an in vitro PD-L1-overexpressing murine Lewis lung carcinoma tumor matrix at 20 and 80 nM; reduces tumor growth and promotes CD8+ and CD4+ T cell tumor infiltration in a PD-L1-overexpressing murine Lewis lung carcinoma model at 20 mg/kg
Bioassay Systems EnzyFluo™ MMP-9 Inhibitor Assay Kit, For evaluation of drugs and screening of potential inhibitors to MMP-9.
MATRIX METALLOPROTEINASE-9 or MMP-9 (EC 3.4.24.35) is a Ca2+-and Zn2+-dependent, interstitial gelatinase that plays a role in the remodeling of the extracellular matrix of tissues. MMP-9 plays a central role in processes diverse as wound healing, angiogenesis, and bone development. In addition to its role in normal growth and development, MMP-9 is up-regulated in many diseases, including metastatic cancer, rheumatoid arthritis, and asthma. BioAssay Systems’ EnzyFluo™ MMP-9 Inhibitor Assay Kit uses a quenched synthetic substrate. Upon digestion by MMP-9, the substrate is cleaved, which abolishes the quenching of the fluorescence label. The fluorescent fragment is measured at λex/em = 490/520 nm. Inhibition is determined by the decrease in fluorescence.
CPC Scientific MCA-Val-Asp-Gln-Met-Asp-Gly-Trp-Lys(DNP)-NH2 0.5MG
Fluorogenic resonance energy transfer substrate for the detection of caspase-3 activity.SEQUENCE: MCA-Val-Asp-Gln-Met-Asp-Gly-Trp-Lys(DNP)-NH2ONE-LETTER SEQUENCE: Mca-VDQMDGWK-(DNP)-NH2MOLECULAR FORMULA: C60H75N14O21S1MOLECULAR WEIGHT: 1360.4STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: SYNONYMS: RESEARCH AREA: ApoptosisREFERENCES:
SKU(s): CASP-060A, CASP-060B
CPC Scientific Biotin-Tyr-Val-Ala-Asp-CMK 0.5MG
Biotinylated analog of the caspase-1 inhibitor.ONE-LETTER SEQUENCE: Biotin-YVAD-CMKMOLECULAR FORMULA: C32H45Cl1N6O9S1MOLECULAR WEIGHT:725.27STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [402474-75-3], SYNONYMS: Biotinyl-Tyr-Val-Ala-Asp-chloromethylketoneRESEARCH AREA: ApoptosisREFERENCES: Y.A. Lazebnik et al., Nature, 371, 346 (1994)
Cayman Chemical FOXM1 InhIbItr III 10mg
An inhibitor of FOXM1 DNA-binding activity (IC50 = 22.5 µM); binds to FOXM1 and is selective for inhibiting FOXM1 transcriptional activity over FOXA1, FOXA2, FOXP2, and GATA-1 transcriptional activity; inhibits the growth of MCF-7, MDA-MB-231, and PEO1 cancer cells (GI50s = 18, 21.8, and 18.1 µM, respectively)
Cayman Chemical GlutamInase C InhIbItr 11 1mg
An inhibitor of GAC; inhibits GAC enzyme activity (EC50 = 10.64 nM); reduces the viability of A549 NSCLC cells (IC50 = 4.025 nM); reduces colony formation by, and intracellular glutamate levels in, A549 cells at 0.1 and 1 µM; reduces tumor growth in an A549 mouse xenograft model at 100 mg/kg