Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Thapsigargin
Thapsigargin, CAS 67526-95-8, is a cell-permeable, tumor-promoting sesquiterpene lactone that releases calcium by non-competitvley inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4-13 nM).
MilliporeSigma™ Calbiochem™ U0126
U0126, CAS 109511-58-2, is a potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK.
MilliporeSigma™ Calbiochem™ Iron Chelator IV, 21H7
The Iron Chelator IV, 21H7 controls the biological activity of iron-regulated enzymes. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Phosphatase Inhibitor Cocktail Set III
Phosphatase Inhibitor Cocktail Set III is a ready to use cocktail of four phosphatase inhibitors for broad-spectrum inhibition of both serine/threonine and protein tyrosine phosphatases.
MilliporeSigma™ Calbiochem™ Protease Arrest™ Reagent
An optimized concentration of various reversible and irreversible inhibitors to inhibit serine, cysteine, and calpain proteases.
MilliporeSigma™ Calbiochem™ InSolution™ Caspase Inhibitor I
The InSolution™ Caspase Inhibitor I controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ TrpA1 Antagonist, HC-030031
The TrpA1 Antagonist, HC-030031, also referenced under CAS 349085-38-7, controls the biological activity of TrpA1. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ TX-1123
A cell-permeable, reversible, and substrate-competitive arylidene-cyclopentenedione derived tyrphostin that acts as an inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC at much higher concentrations.
MilliporeSigma™ Calbiochem™ Zebularine
A cell-permeable chemically stable cytidine analog that displays antitumor properties.
MilliporeSigma™ Calbiochem™ Xestospongin C, Xestospongia sp.
An oxaquinolizidine alkaloid isolated from a marine sponge.
MilliporeSigma™ Calbiochem™ Wortmannin
Wortmannin, CAS 19545-26-7, is a cell-permeable, potent, selective, and irreversible inhibitor of PI3-Kinase (IC50 = 5 nM). Does not affect any upstream signaling events.
MilliporeSigma™ Calbiochem™ VEGF Inhibitor, CBO-P11
The VEGF Inhibitor, CBO-P11 controls the biological activity of VEGF. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Trio N-Terminal RhoGEF Domain Inhibitor, ITX3
The Trio N-Terminal RhoGEF Domain Inhibitor, ITX3, also referenced under CAS 347323-96-0, controls the biological activity of Trio N-Terminal RhoGEF Domain. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ TLR3/dsRNA Complex Inhibitor
The TLR3/dsRNA Complex Inhibitor blocks dsRNA binding to TLR3.
MilliporeSigma™ Calbiochem™ TNF-α Antagonist
The TNF-α Antagonist controls the biological activity of TNF-α.