Protease Inhibitors and Phosphatase Inhibitors
STEMCELL Technologies Etoposide, Size: 500 mg
Inhibit proliferation of cancer cells by inhibiting topoisomerase II activity with Etoposide. Highly potent and cell-permeable etoposide inhibits topoisomerase II (IC50 60.3) from religating broken DNA strands by forming a complex with topoisomerase II and DNA which leads to cell death (Wu et al.). Etoposide has also been used as a way to trigger and model cellular senescence in vitro (Bang et al. Te Poele et al. Teng et al. Yang et al.)
Cayman Chemical STAT5 InhIbItr 25mg
A cell-permeable, nonpetidic nicotinoyl hydrazone that selectively suppresses STAT5 by targeting its SH2 domain (IC50 = 47 µM against STAT5β SH2 domain EPO peptide binding activity)
Enzo Life Sciences Protease Inhibitor CocktaIL-(1Set)
Solubility: Soluble in aqueous buffers, or add directly to extraction media. Alternatively, prepare 7X stock solutions in 1.5ml water or 100mM phosphate buffer, pH 7.0. Long Term Storage: +4°C.
Enzo Life Sciences Phosphoramidon (5mg). CAS: 119942-99-3
Inhibits neutral endopeptidase 24.11 (NEP, neprilysin; EC 3.4.24.11) (Ki=2nM), a cell surface zinc metalloprotease which cleaves bioactive peptides such as bradykinin, neurotensin, and enkephalin. Also inhibits neprilysin 2 (Ki~2nM). Potent inhibitor of endothelin-converting enzyme (ECE) (IC50=0.68μM). Alternative name: N-(alpha-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan. Purity: ≥97% (HPLC). Solubility: Soluble in water, DMSO or methanol. Long Term Storage: -20°C.
Medchemexpress LLC Casein kinase inhibitor A86 | 2079069-01-3 | 99.3% | 344.43 | C18H25FN6 | 10MG
Casein Kinase inhibitor A86 is a small-molecule research compound that potently inhibits casein kinase 1α (CK1α) and shows activity against CDK7 and CDK9. It has demonstrated induction of leukemia cell apoptosis in preclinical studies and is provided for laboratory research use only.
- Potent CK1α inhibition with cellular activity.
- Also inhibits CDK7 and CDK9, enabling multi-kinase profiling.
- Demonstrated induction of leukemia cell apoptosis in preclinical models.
- High purity (99.3%) suitable for biochemical and cellular assays.
- Available in small pack sizes to support screening and follow-up studies.
- Stable as a powder when stored under recommended conditions.
Cayman Chemical IRAK14 InhIbItr 5mg
A benzimidazole that selectively disrupts the activity of IRAK 1 and 4 (IC50 = 0.3 and 0.2 µM, respectively)
Cayman Chemical Mpro InhIbItr 11b 5mg
An inhibitor of Mpro (IC50 = 0.04 µM in a TR-FRET assay); reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50 = 0.72 µM); reduces viral RNA copy numbers in the same model from 1.85-50 µM
Cayman Chemical ThIordoxIn Rducts 1 InhIb 25mg
An irreversible inhibitor of TrxR1 (IC50 = 0.012 µM); inhibits TrxR1-induced reduction of Trx1 in a cell-free assay (IC50 = 4.3 µM); reduces the mitochondrial oxygen consumption rate in HCT116 cells at 10 µM; increases the intracellular levels of hydrogen peroxide in FaDu cancer cells in a time- and concentration-dependent manner; decreases the viability of FaDu cells (IC50 = 0.72 µM); decreases tumor growth in a FaDu HNSCC mouse xenograft model at 10 mg/kg twice per day; induces apoptosis in a FaDu HNSCC mouse xenograft model at 5 mg/kg daily; toxic to S. mansoni adult worms (LD50 = 10.07 µM)
Cayman Chemical ENPP3 InhIbItr 1mg
An ENPP3 inhibitor (Ki = 53.7 nM); selective for ENPP3 over ENPP1, ENPP2, TNAP, CD73, NTPDase 1, NTPDase 2, and NTPDase 3; inhibits CAII and CAIX (Kis = 74.7 and 20.3 nM, respectively)
Cayman Chemical BCATc InhIbItr 2 5mg
A sulfonyl hydrazide that inhibits BCATc (IC50s = 0.81 and 0.2 µM in human and rat, respectively) with 15-fold selectivity over BCATm; blocks calcium influx into neurons (IC50 = 4.8 µM) following inhibition of glutamate uptake and demonstrates neuroprotective efficacy in vivo
Apexbio Technology LLC Survivin suppressor, induces apoptosis 781661-94-7. MFCD11983133
Survivin suppressor, induces apoptosis 781661-94-7. MFCD11983133
Cayman Chemical GSK3 InhIbItr 1 10mg
A GSK3β inhibitor (IC50 = 4.19 nM); decreases blood glucose levels in an OGTT in a rat model of high-fat diet and STZ-induced diabetes at 50 mg/kg
Research Products International Corp RPI (-)-p-Bromotetramisole Oxalate, 5 Milligrams
Potent alkaline phosphate inhibitor. Mimics the action of orthovanadate in the potentiation of fluorouracil antiproliferative activity. Cell permeable.
![Medchemexpress LLC 2-((3-(4-ethoxyphenyl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl)thio)-N-(4-fluorophenyl)acetamide | 721964-51-8 | 98.3% | 423.46 | C21H18FN5O2S | 5mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000270269.png-250.jpg)
Medchemexpress LLC 2-((3-(4-ethoxyphenyl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl)thio)-N-(4-fluorophenyl)acetamide | 721964-51-8 | 98.3% | 423.46 | C21H18FN5O2S | 5mg
Protein kinase inhibitor 11 (Compound I-96) is a protein kinase inhibitor that can inhibit the activity of PIM-1 CDK-2 GSK-3 and SRC Protein kinase inhibitor 11 holds promise for research in cancer immune disorders and neurodegenerative diseases[1]
Medchemexpress LLC Legumain inhibitor 1 | 2361157-34-6 | 98.3% | 50 MG
Legumain inhibitor 1 is a potent and selective Legumain inhibitor with an IC50 of 3.6 nM. It is primarily used for cancer research and demonstrates high microsomal stability, with half-lives exceeding 8 hours in both mouse and human microsomes (CLint > 3 μL/min/mg).
- Potent and selective Legumain inhibitor
- IC50 of 3.6 nM
- Suitable for cancer research
- High microsomal stability with half-lives exceeding 8 hours in mouse and human microsomes