Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ PKG Iα Inhibitor, Cell-Permeable
The PKG Iα Inhibitor, Cell-Permeable controls the biological activity of PKG Iα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Guanosine 3',5'-cyclic Monophosphate, Sodium Salt
Important intracellular second messenger implicated in the action of nitric oxide in many cell types.
MilliporeSigma™ Calbiochem™ HDL Receptor SR-BI Inhibitor, BLT-1
The HDL Receptor SR-BI Inhibitor, BLT-1, also referenced under CAS 321673-30-7, controls the biological activity of HDL Receptor SR-B. This small molecule/inhibitor is primarily used for Phosphorylation and Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ GW7647
A cell-permeable urea-substituted thioisobutyric acid compound that acts as a potent and selective PPARα.
MilliporeSigma™ Calbiochem™ Histone Acetyltransferase p300 Inhibitor, C646
Histone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400nM). Competes with acetyl-CoA for the p300 Lys-CoA binding pocket.
MilliporeSigma™ Calbiochem™ (±)-Ibuprofen
A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC50 = 4.85 μM).
MilliporeSigma™ Calbiochem™ IKK Inhibitor III, BMS-345541
IKK Inhibitor III, BMS-345541, CAS 445430-58-0, is a cell-permeable, potent, selective, and allosteric site-binding inhibitor of IKK-2 (IC50 = ≈300 nM).
MilliporeSigma™ Calbiochem™ ATIC Dimerization Inhibitor
A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691 nM, Kd = 2
MilliporeSigma™ Calbiochem™ Leukadherin-1
A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B.
MilliporeSigma™ Calbiochem™ Parthenolide, Tanacetum parthenium
A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties.
MilliporeSigma™ Calbiochem™ PKM2 Activator II, DASA
The PKM2 Activator II, DASA modulates the biological activity of PKM2. This small molecule/inhibitor is primarily used for Biochemicals applications.
MilliporeSigma™ Calbiochem™ Caspase-1/4 Inhibitor, VX-765
A cell-permeable prodrug that upon conversion to its active form inhibits caspase-1 and 4 activity (Ki = 800 pM and 600 pM, respectively).
MilliporeSigma™ Calbiochem™ MitoBloCK-6
A cell-permeable, stable dichlorosalicylaldehyde Schiff's base that acts as a potent, selective inhibitor of Mia40/Erv1 redox-mediated import pathway (IC50 = 700 nM, 900 nM, an
MilliporeSigma™ Calbiochem™ (+/-)-Clopidogrel Hydrogensulfate
A thienopyridine compound that acts as a specific irreversible inhibitor of purinergic P2Y12 recept
MilliporeSigma™ Calbiochem™ Protease Inhibitor Cocktail Set II
The Protease Inhibitor Cocktail Set II controls the activity of Protease. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.