Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ 2-APB
A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release.
MilliporeSigma™ Calbiochem™ Quinacrine, Dihydrochloride
A non-specific phospholipase A2 (PLA2) inhibitor.
MilliporeSigma™ Calbiochem™ WP1130
A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway.
MilliporeSigma™ Calbiochem™ USP1-UAF1 Inhibitor, ML323
A cell-permeable, selective, potent, and reversible inhibitor of USP1-UAF1 deubiquitinase (IC50 = 76 nM in Ub-Rhodamine based assays). Does not disrupt USP1-UAF1 association.
MilliporeSigma™ Calbiochem™ SIRT1 Activator II
The SIRT1 Activator II, also referenced under CAS 374922-43-7, modulates the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Biochemicals applications.
MilliporeSigma™ Calbiochem™ PICK1 PDZ Domain Inhibitor, FSC231
The PICK1 PDZ Domain Inhibitor, FSC231 controls the biological activity of PICK1. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ L-(–)-Norepinephrine-(+)-bitartrate
α,β-Adrenergic agonist.
MilliporeSigma™ Calbiochem™ Rolipram
A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 800 nM).
MilliporeSigma™ Calbiochem™ InSolution™ Staurosporine, Streptomyces sp.
InSolution™ Staurosporine, Streptomyces sp. CAS 62996-74-1, is provided as a 1mm (100μg/214μl) solution of Staurosporine (Cat. No. 569397) in DMSO
MilliporeSigma™ Calbiochem™ Genistin
An isoflavone glycoside found in soy-based food products.
MilliporeSigma™ Calbiochem™ InSolution™ TGF-β RI Kinase Inhibitor II, RepSox
A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4nM and 18nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively)
MilliporeSigma™ Calbiochem™ JNK Inhibitor II, Negative Control
The JNK Inhibitor II, Negative Control, also referenced under CAS 54642-23-8, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ CD40-TRAF6 Signaling Inhibitor, 6877002
A cell-permeable compound that specifically targets TRAF6 (Kd = 97 μM for TRAF6 C-domain) and disrupts its functional coupling with CD40.
MilliporeSigma™ Calbiochem™ InSolution™ Bcl-2 Inhibitor VI, ABT-737
A 25 mM (5 mg/246 μL) solution of Bcl-2 Inhibitor VI, ABT-737 in DMSO.
MilliporeSigma™ Calbiochem™ Stearoyl-CoA Desaturase 1 Inhibitor, MF-438
Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, CAS 921605-87-0, is a cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1; IC50 of 2.3nM).