Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Leupeptin, Hemisulfate, Synthetic
Synthetic version of the microbial-derived inhibitor Leupeptin against trypsin-like and cysteine protease activities.
MilliporeSigma™ Calbiochem™ Curcumin, Curcuma longa L.
A cell-permeable and irreversible antitumor and anti-inflammatory agent that acts as an inhibitor of 5-lipoxygenase (IC50 = 8 μM) and cyclooxygenase (IC50 = 52 μM).
MilliporeSigma™ Calbiochem™ ERO1 Inhibitor I, Erodoxin
The ERO1 Inhibitor I, Erodoxin controls the biological activity of ERO1.
MilliporeSigma™ Calbiochem™ Syk Inhibitor III
The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ HIF-1 Inhibitor
The HIF-1 Inhibitor, also referenced under CAS 934593-90-5, controls the biological activity of HIF-1.
MilliporeSigma™ Calbiochem™ IM-412
IM-412 primarily used in Inhibition.
MilliporeSigma™ Calbiochem™ InSolution™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1
A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25μM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex format
MilliporeSigma™ Calbiochem™ PP2A Activating Ligand, ITH12246
A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A)
MilliporeSigma™ Calbiochem™ JAK3/GSK-3β/PKCα Inhibitor
The JAK3/GSK-3β/PKCα Inhibitor, also referenced under CAS 1260181-14-3, controls the biological activity of JAK3/GSK-3β/PKCα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Psalmotoxin-1
A potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC50 = 0.9 nM) that can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b.
MilliporeSigma™ Calbiochem™ ALLM
Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM).
MilliporeSigma™ Calbiochem™ InSolution™ Gö 6976
Inhibitor of protein kinase C (PKC; IC50 = 7
MilliporeSigma™ Calbiochem™ FK-506, Streptomyces sp.
Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.
MilliporeSigma™ Calbiochem™ Tubulin Polymerization Inhibitor II
The Tubulin Polymerization Inhibitor II, also referenced under CAS 1151995-69-5, acts as an effective anti-microtubule agent. This small molecule/inhibitor is primarily used for Cell Structure applications.