Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ InSolution™ KN-93
A cell-permeable, competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 370nM)
MilliporeSigma™ Calbiochem™ (±)-Bay K 8644
Synthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types.
MilliporeSigma™ Calbiochem™ Caspase-8 Inhibitor II
The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor III
A cell-permeable benzothiazolylchromenone compound that disrupts Skp2-Skp1 interaction via direct Skp2 affinity binding and selectively prevents Skp2-, but not Fbw7- or β-TrCP-, Skp1-Cullin-1-F-box (SFC) complex-mediated substrates ubiquitination, effectively preventing Skp2 substrates activation (Akt) and degradation (p21 & p27) with concomitant down-regulation of cellular Skp2 protein level (10 to 20μM in HEK293T & PC3 cultures)
MilliporeSigma™ Calbiochem™ Protease Inhibitor Cocktail Set V, EDTA-Free
A cocktail of four protease inhibitors for the inhibition of serine, cysteine, but not metalloproteases.
MilliporeSigma™ Calbiochem™ ATM/ATR Kinase Inhibitor
The ATM/ATR Kinase Inhibitor, also referenced under CAS 905973-89-9, controls the biological activity of ATM/ATR Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ PFKFB3 Inhibitor III, YN1
A cell-permeable, potent and competitive inhibitor of fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 670 nM).
MilliporeSigma™ Calbiochem™ DNA Methyltransferase Inhibitor
The DNA Methyltransferase Inhibitor, also referenced under CAS 32675-71-1, controls the biological activity of DNA Methyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ Roscovitine
A potent, reversible, and selective inhibitor of Cdks that exhibits about 10-fold greater efficacy towards p34-cdk1 and p33-cdk2 and 20-fold greater efficacy towards p33-cdk5 relative to Olomoucine.
MilliporeSigma™ Calbiochem™ PDE5 Inhibitor, Cpd7a
A cell-permeable, highly potent and selective inhibitor of phosphodiesterase 5 (PDEV; IC50 = 270 pM).
MilliporeSigma™ Calbiochem™ NS 2028
Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase.
MilliporeSigma™ Calbiochem™ TRPC3 Channel Inhibitor III, Pyr10
A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) and inhibits Carbachol- (
MilliporeSigma™ Calbiochem™ RuBi-Nicotine
A highly water soluble Ruthenium-bisbipyridine-caged nicotine that can be un-caged by blue and green light
MilliporeSigma™ Calbiochem™ CGP 7930
A blood brain barrier permeable, positive allosteric modulator of the metabotropic GABAB recep