Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Calpain Substrate IV, Cell-Permeable, Fluorogenic
The non-permeant fluorogenic Calpain Substrate III is made cell-permeable by a c-terminal heptaarginine extension via a Glu linkage.
MilliporeSigma™ Calbiochem™ (+)-Brefeldin A, Eupenicillium brefeldianum
Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function.
MilliporeSigma™ Calbiochem™ BX-795
BX-795, also referenced under CAS 702675-74-9, modulates the biological activity of multiple kinases. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ CA-074
CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Adenosine 3',5'-cyclic Monophosphate, 8-Bromo-, Sodium Salt
Cell-permeable cAMP analog that has greater resistance to phosphodiesterases than cAMP.
MilliporeSigma™ Calbiochem™ CaMKII Inhibitor, CK59
The CaMKII Inhibitor, CK59, also referenced under CAS 140651-18-9, controls the biological activity of CaMKII. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ bpV(phen)
A potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator.
MilliporeSigma™ Calbiochem™ Calpastatin Peptide, Negative Control
A scrambled peptide with an identical amino acid composition to that of Calpastatin Peptide. Useful as a negative control for Calpastatin Peptide.
MilliporeSigma™ Calbiochem™ Granzyme B Substrate VIII, Colorimetric
A colorimetric substrate for granzyme B (kcat/Km = 6.6 x 104 M-1s-1).
MilliporeSigma™ Calbiochem™ Guanosine 3',5'-cyclic Monophosphate, Sodium Salt
Important intracellular second messenger implicated in the action of nitric oxide in many cell types.
MilliporeSigma™ Calbiochem™ Batimastat
Batimastat primarily used in Inhibition.
R&D Systems™ Pan Caspase OPH Inhibitor Q-VD, Non-omethylated
Cell-permeable, irreversible inhibitor of caspase activity. Q-VD-OPh does not exhibit toxic effects at typical working concentrations.
MilliporeSigma™ Calbiochem™ Memantine Hydrochloride
Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.
MilliporeSigma™ Calbiochem™ Myeloperoxidase Inhibitor-II
A 5-fluorotryptamine derivative that inhibits myeloperoxidase/MPO activity (IC50 = 18nM) via direct affinity interaction with enzyme active site heme pyrrole ring D, while exhibiting much reduced affinity toward serotonin reuptake transporter/SERT ( K i
MilliporeSigma™ Calbiochem™ Tankyrase 1/2 Inhibitor VI, G007-LK
Tankyrase 1/2 Inhibitor VI, G007-LK, CAS 1380672-07-0, is a cell-permeable, potent and highly selective inhibitor of tankyrase (IC50 = 33 and 26nM for TNKS1 and TNKS2, respectively).