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Substrates are laboratory reagents, chemicals, and consumables, and kits used to support or enhance biomedical, pharmaceutical, clinical, food science, environmental, and other research and testing laboratory processes. Products include enzymes, inhibitors, acids, bases, buffers, antibodies, and chromatography supplies.
This peptide, EAIYAAPFAKKK, was identified as a high affinity (Km=4 µM) and specific substrate for the Abl kinase through a degenerate peptide library. The three lysines on the carboxy-terminus allow this peptide to be used in phosphocellulose kinase assays. Purity: ≥95%. Long Term Storage: -20°C.
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IPTG Isopropyl-β-D-Thiogalactopyranoside. An inducer of β-galactosidase used to promote the expression of proteins in cells controlled by the lac operator system. For blue/white screening, 0.1mM final IPTG concentration in LB (Luria Broth) media is recommended. Techncial Information:Biotechnology Grade.Dioxane free.
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The Histone H3 Peptide (1-21) sequence (ARTKQTARKS-TGGKAPRKQLAGGKKC) is derived from human histone H3 (1-21) and is suitable for use as the substrate for histone methyltransferase (at K4 and K9) and acetyltransferase (at K9 and K14) family assays.
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K-Gold Substrate is a one-bottle stabilized chromogenic substrate for use with alkaline phosphatase based immunoassays. K-Gold Substrate utilizes the substrate p-nitrophenyl-phosphate (PNPP), which reacts with alkaline phosphatase to produce the chromophore p-nitrophenol. NEOGENs ready-to-use K-Gold formula does not require mixing of additional ingredients or stabilizing agents, making it an ideal formula for kit manufacturers. Stable for a minimum of 30-months when stored at 2-8C.
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Ac-WLA-AMC (Ac-Trp-Leu-Ala-AMC; CAS 1104011-59-7) is an acetylated tripeptidyl fluorogenic substrate for measuring the chymotrypsin-like activity of the 20S proteasome β5 (β5c) subunit. Enzymatic cleavage releases 7-amino-4-methylcoumarin (AMC), producing a fluorescent signal used in proteasome activity assays and inhibitor screening.
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The HER2/CD340 protein is a dynamic tyrosine kinase that is essential in the neuregulin receptor complex and regulates microtubule dynamics Upon activation it triggers the MEMO1-RHOA-DIAPH1 pathway inhibits GSK3B and promotes the association of APC and CLASP2 on the cell membrane to achieve microtubule stabilization HER2/CD340 Protein Human (S310Y HEK293 His) is the recombinant human-derived HER2/CD340 protein expressed by HEK293 with C-10 His labeled tag and S310Y mutation
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