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For researchers, scientists, and technical professionals: Your one-stop shop for the complete range of laboratory, production, and safety products and services.
A variety of media, supplemental media components, and reagents suitable for cell culture operations and processes. Products include fully prepared media as well as antibiotics, growth factors, contamination detection and removal reagents, cell dissociation reagents, and more.
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ICA-105665 (PF-04895162) is a small-molecule opener of neuronal Kv7 potassium channels supplied as a solid for laboratory research use. It crosses the blood-brain barrier, has demonstrated broad-spectrum antiseizure activity in animal models, and displays BSEP inhibition at high concentrations. Store and handle according to solubility and storage recommendations for research compounds.
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This small-molecule inhibitor is selective for aquaporin-7 (AQP7) and intended for laboratory research. It inhibits mouse AQP7 with an IC50 of ~0.2 μM and shows weaker activity against AQP3 and AQP9 (IC50s ~0.7 μM and ~1.1 μM). The compound has formula C20H20N4O3, molecular weight 364.40 g/mol, and a reported purity of 98.1%.
Potent and selective inhibitor of aquaporin-7 (AQP7).
Submicromolar activity against mAQP7; less potent against mAQP3 and mAQP9.
High reported purity (98.1%).
High solubility in DMSO (≥280 mg/mL) with reported in vivo formulation options.
Stable when stored as powder at -20°C (up to 3 years) or 4°C (up to 2 years).
Available in multiple solid and solution formats for research use.
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SYM 2081 is a selective, high-affinity kainate receptor agonist used as a laboratory research reagent to study glutamatergic signaling, transporter function, neuroprotection, and apoptotic pathways. Intended for research use only and supplied as a white to off-white solid with manufacturer-provided characterization.
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LYN-1604 dihydrochloride is a research-grade small molecule activator of UNC-51-like kinase 1 (ULK1), used to study autophagy and cell death pathways in preclinical models such as triple negative breast cancer. The compound is supplied as the dihydrochloride salt and is provided with analytical documentation for research use.
Potent ULK1 activator (EC50 = 18.94 nM).
High purity suitable for research applications.
Available as solid and as a DMSO solution for convenient dosing.
Analytical documentation available, including COA, HNMR, and LCMS.
Supplied as the dihydrochloride salt for consistent formulation.
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Pool of 50 lyophilized oligopeptides, consisting of MHC class I and class II restricted peptides derived from different proteins, of human Adenovirus (AdV) serotype -02 and -05..
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Spiramycin is a 16-member macrolide antibiotic supplied as a research reagent with activity against susceptible bacteria and Toxoplasma gondii. It is provided with documented purity and identification data, and is intended for laboratory research use only, not for clinical or human use.
Macrolide antibiotic with antibacterial and antiparasitic activity.
Documented CAS number and molecular formula for unambiguous identification.
High purity suitable for research applications.
Available in multiple pack sizes, including a 500 mg pack.
For research use only; not for human or clinical use.
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Ciliobrevin D is a cell-permeable, reversible inhibitor of the AAA+ ATPase motor cytoplasmic dynein used in research to disrupt dynein-dependent microtubule gliding and ATPase activity, and to inhibit Hedgehog signaling and primary cilia formation.
High purity research-grade compound (99.4%).
Molecular formula C17H8Cl3N3O2 and molecular weight 392.62 g/mol.
Solid form, commonly supplied in small milligram quantities, including 50 mg.
Cell-permeable and reversible inhibitor of cytoplasmic dynein activity for in vitro studies.
Useful for studies of Hedgehog signaling, cilia formation, and microtubule dynamics.
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Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki = 0.16 nM). It is supplied as the hydrochloride salt for research use only.
Potent inverse agonist at the histamine H3 receptor (Ki = 0.16 nM).
Hydrochloride salt form for research handling and stability.
Molecular weight 332.31 and formula C17H27Cl2NO.
CAS number 903576-44-3 for precise identification.
Intended for research use only; not for human or clinical use.
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Xanomeline as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist increases neuronal excitability Xanomeline can be used for the research of neurological disorders such as schizophrenia[1 [2
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